All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 337–360 of 943 models
STACK
142115—Single-cell foundation model using tabular attention over context cells to predict responses to arbitrary perturbations without fine-tuning.
Single-cell33OpennessSurfFlow
———Flow-matching model for therapeutic peptide design that co-designs sequence, structure, and molecular surface to disrupt protein-protein interactions.
ProteinSmall molecule18OpennessCMAP
———Antibody developability predictor pairing text and protein language models, using in-context learning to fit new assays without retraining.
ProteinLanguage model4OpennessDNAChunker
—1—Masked DNA language model with a learnable, adaptive tokenizer that produces context-dependent, variable-length segments instead of fixed k-mers.
DNA & Gene23OpennessBiomeGPT
—1—Massachusetts General HospitalJanuary 5, 2026biomarker_discoverydisease_classificationfoundation_model+6Gut microbiome foundation model pretrained on human shotgun metagenomes, learning species-level taxonomic representations for disease prediction.
DNA & GeneLanguage model8OpennessMetagenBERT
———Annotation-free metagenome embedding pipeline that encodes raw DNA reads with genomic language models and pools them via FAISS k-means clustering.
DNA & Gene22OpennessNetMedGPT
—2—Transformer foundation model pretrained on a biomedical knowledge graph for zero-shot drug repurposing, target, and adverse-effect prediction.
Language modelSmall molecule24OpennessGEMGen
—2—Generative language model for phenotype-driven drug discovery, proposing small-molecule structures from up- and down-regulated gene signatures.
Small moleculeSingle-cell9OpennessMultimodal architecture coupling pretrained DNA, RNA, and protein language models with directional cross-attention into one Virtual Cell Embedding.
DNA & GeneRNAProtein22OpennessPeptiVerse
—11—University of Pennsylvania +1 otherJanuary 3, 2026binding_affinity_predictiondrug_discoverygradient_boosting+4Peptide developability predictor scoring solubility, permeability, toxicity, and binding from amino-acid sequences or chemically modified SMILES.
ProteinSmall molecule81OpennessMerlin
452517.3K3D vision-language foundation model for abdominal CT, pretrained on scans, radiology reports, and EHR codes for zero-shot interpretation.
ImagingLanguage model54OpennessSpatialDINO
—193—Native 3D vision transformer self-supervised on unlabeled fluorescence microscopy volumes, segmenting subcellular structures without voxel labels.
Imaging8OpennessMicroGenomer
10——470M-parameter microbial genome foundation model trained on 234.5B base pairs for multi-scale genomic representation and trait prediction.
DNA & Gene44OpennessOmniCell
—1—Transcriptomic foundation model pretrained on 67M single-cell and spatial profiles, modeling gene expression and inter-cellular dependencies.
Single-cellSpatial omics9OpennessHELM-BERT
14—1.4KPeptide language model trained on HELM notation, a DeBERTa encoder for property prediction on macrocyclic and non-canonical medium-sized peptides.
Small molecule80OpennessGenoME
—1—Mixture-of-Experts generative model turning DNA sequence plus cell-type ATAC-seq into unified epigenomic, transcriptomic, and 3D chromatin profiles.
DNA & GeneSingle-cell8OpennessSpatially aware transcriptomic foundation models for cancer, pairing 50um-Local and 250um-Extended views of spot-resolution spatial transcriptomes.
Spatial omics12OpennessMAGNET
—152—Huazhong University of Science and TechnologyDecember 25, 2025denoisingfluorescence_microscopyfoundation_model+7Microscopy image restoration foundation model unifying 8 tasks across 5 modalities and 2D/3D data, with zero-shot inference on unseen systems.
Imaging7OpennessmRNA-GPT
41—GPT-style generative language model for mRNA coding sequences, pretrained across bacteria, eukaryotes, and archaea for de novo CDS design.
RNA39OpennessFOCUS
———Generative foundation model that imputes genes and denoises spatial transcriptomics, conditioned on H&E histology, scRNA-seq, and spatial priors.
Spatial omicsPathologySingle-cell4OpennessRFdiffusion3
90764—All-atom protein design diffusion model conditioned on ligands, nucleic acids, and other non-protein atoms, supporting enzyme and DNA binder design.
Protein80OpennessNucleotide Transformer v3 (NTv3)
8972195.9KMulti-species genomics foundation model spanning representation learning, functional-track prediction, and sequence generation at 1 Mb context.
DNA & Gene25OpennessProFam
58——Protein-family language model trained on unaligned homolog sets for zero-shot variant fitness prediction and design. ProFam-1 holds 251M parameters.
Protein86OpennessHelix
—36—Structure-aware transformer that makes zero-shot, per-adenosine predictions of ADAR-mediated A-to-I RNA editing to guide therapeutic guide-RNA design.
RNA4Openness