All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 1–24 of 710 models
CREP
———Fine-tuned Enformer derivative that predicts discrete, interpretable cis-regulatory element class annotations (enhancer, promoter, insulator) directly from DNA sequence across human cell types.
DNA & Gene8OpennessVelocityFM
———University of Colombo School of Computing +1 otherJune 7, 2026conformational_samplingflow_matchinggenerative+5A generative protein-dynamics model that predicts short-horizon MD trajectories using rectified flow matching in velocity space over residue frames and torsions.
Protein21OpennessMethylSeqNet
———University of California, Berkeley +1 otherJune 7, 2026chromatin_accessibility_predictiondna_methylationepigenetics+6Conditions a pretrained DNA sequence embedding on CpG methylation to predict gene regulation across cell types and alleles, generalizing zero-shot to imprinting, X-inactivation, and accessibility.
DNA & Gene18OpennessBacteReason
———University of TokyoJune 7, 2026antimicrobial_resistanceantimicrobial_resistance_predictionbacteria+5A reasoning LLM fine-tuned on clinical antimicrobial-susceptibility data augmented with mechanistic rationales, predicting susceptibility with explanations for novel isolate-antibiotic pairs.
DNA & GeneLanguage model20OpennessCryoDiff
———Uncertainty-aware diffusion model that enhances cryo-EM density maps while estimating voxel-wise confidence via Monte Carlo sampling.
Imaging20OpennessCellpin
———A VAE trained on scRNA-seq reference data and applied frozen at inference to impute unmeasured genes and denoise spatial transcriptomics profiles.
Spatial omicsSingle-cell22OpennessDaX
2——Pathology vision foundation model adapting DINOv3-style self-supervised learning to whole-slide histopathology across continuous magnifications and scales.
Pathology11OpennessEmap2lig
1——A two-stage deep learning framework that detects ligand densities in cryo-EM maps and reconstructs their atomic structures with a diffusion generative model.
ImagingSmall molecule25OpennessReCLIP
———University of Chicago +2 othersJune 4, 2026multi_taskpeptide_mhc_binding_predictionprotein_protein_interaction_prediction+5Transformer framework that models protein-protein interactions at residue resolution, generalizing zero-shot to unseen MHC alleles and sequence-neutral PTMs from one fixed checkpoint.
Protein22Opennessdrug-SFM
———Specificity Foundation Model that predicts small-molecule drug-target protein specificity from sequence using a physics-derived dual-encoder with symmetric contrastive learning.
Small molecule16OpennessDiffusion-based backbone generation and sequence design method for programmable asymmetric transmembrane beta-barrel nanopores.
Protein17Opennessmir-SFM
———Specificity Foundation Model that predicts microRNA-mRNA target specificity from sequence using a physics-derived dual-encoder with symmetric contrastive learning.
RNA25Opennesstf-SFM
———Specificity Foundation Model that predicts transcription factor-DNA binding specificity from sequence using a physics-derived dual-encoder with symmetric contrastive learning.
DNA & Gene18Opennessenzyme-SFM
———Specificity Foundation Model that predicts enzyme-substrate specificity from sequence using a physics-derived dual-encoder with symmetric contrastive learning.
Protein23OpennessFlashABB
8——Oxford Protein Informatics Group (OPIG)June 4, 2026antibodydevelopability_predictionfoundation_model+4Pretrained antibody structure predictor that outputs full paired heavy/light 3D structures faster than protein language models generate embeddings.
Protein54OpennesscrisprSFM
———Specificity Foundation Model that predicts CRISPR gRNA off-target DNA specificity from sequence using a physics-derived dual-encoder with symmetric contrastive learning.
DNA & Gene19OpennessmhcSFM
———Specificity Foundation Model that predicts peptide-MHC binding specificity from sequence using a physics-derived dual-encoder with symmetric contrastive learning.
Protein23OpennessLDARNet
—1—A 120M-parameter genomic foundation model that learns adaptive DNA token boundaries via H-Net-style dynamic chunking instead of fixed k-mer or byte-pair tokenization.
DNA & Gene26OpennessSQUALL
———Multimodal foundation model pretrained on 1.76 billion paired histology-spatial transcriptomics spots, linking whole-slide images to spatial molecular programs.
PathologySpatial omics6OpennessmiDGD
———A deep generative decoder that infers microRNA expression directly from bulk or single-cell mRNA gene expression via a shared mRNA/miRNA latent space.
RNASingle-cell8OpennessBrainGFM
173—A graph foundation model for fMRI brain networks, pretrained across 27 datasets with graph and language prompts for zero/few-shot generalization to unseen disorders.
Biosignals16OpennessPepForge
4——A hierarchical three-stage cascade that generates chemically modified and macrocyclic peptides in HELM notation, supporting de novo design and constrained infilling.
ProteinSmall molecule94OpennessCryoProt
———Protein pretraining framework that learns representations directly from cryo-EM density maps, transferring to flexibility, active-site, binding-affinity, and stability tasks.
ImagingProtein11Openness