All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 361–384 of 943 models
PXDesign
23623—De novo protein binder design suite from ByteDance pairing diffusion and hallucination generators with confidence-based filtering of designs.
Protein65OpennessHD-Prot
7113—Multimodal protein language model that adds a continuous-token diffusion head to a discrete pLM, modeling structure without vector quantization.
Protein14OpennessM-Optimus
———Multimodal foundation model that embeds histology, transcriptomics, and clinical records in one space for patient stratification and target discovery.
PathologySpatial omicsSingle-cell3OpennessEXAONE Path 2.5
5261Pathology foundation model that aligns whole-slide images with genomic, epigenetic, and transcriptomic data for patient-level tumor representations.
PathologySpatial omics14OpennessGlycanGT
3——Graph transformer foundation model for glycans, learning reusable embeddings of branched carbohydrate structures for glycomics prediction tasks.
Small molecule82OpennessOmniNovo
———Fudan University +8 othersDecember 13, 2025de_novo_peptide_sequencingfoundation_modelmass_spectrometry+4De novo peptide sequencing transformer that reads modified and unmodified peptides directly from tandem mass spectra without a reference database.
Protein14OpennessSynPROTAC
———Designs synthesizable PROTAC degraders from reaction templates and purchasable building blocks, with reinforcement learning tuning the generator.
Small molecule11OpennessEva
—4—Enable Medicine +4 othersDecember 12, 2025cell_type_annotationcross_modal_inferencefoundation_model+8Tissue imaging foundation model pretrained on matched H&E histology and spatial proteomics for cross-modal inference and zero-shot retrieval.
PathologySpatial omics4Opennessvir2vec
358396Pan-viral genomic language model producing fixed genome-level embeddings of viral DNA and RNA, reused across classification tasks without retraining.
DNA & Gene53OpennessProteinEBM
—7—Energy-based model of protein conformational space, turning a diffusion model into a statistical potential for structure ranking and mutation scoring.
Protein8OpennessPlantBiMoE
8—5Plant genome foundation model pairing a bidirectional Mamba backbone with sparse Mixture-of-Experts, pretrained on 25.4B nucleotides from 42 species.
DNA & Gene53OpennessOMTRA
67——Structure-based drug design model that unifies de novo generation, docking, conformer generation, and pharmacophore conditioning via flow matching.
Small moleculeProtein72OpennessRFdiffusion2
4373—Atom-level diffusion model for de novo enzyme design that scaffolds arbitrary active-site geometries without specifying catalytic residue positions.
Protein69OpennessPRIMO
51—Harvard University +4 othersDecember 2, 2025deep_mutational_scanningin_context_learningprotein_engineering+4Transformer for few-shot protein fitness prediction that combines in-context learning with test-time training to adapt to new proteins and assays.
Protein61OpennessPanFoMa
2——Pan-cancer single-cell foundation model with a hybrid Transformer-Mamba architecture, released with the PanFoMaBench cancer evaluation benchmark.
Single-cell13OpennessISTS
———Pan-cancer multi-omic foundation model encoding CpG-island DNA methylation and RNA-seq for zero-shot cancer classification and mutation prediction.
Single-cellDNA & Gene20OpennessscMOBA
—11—Chinese Academy of Sciences +1 otherDecember 2, 2025cell_biologycell_type_annotationdata_integration+5Conversational single-cell and spatial multi-omics brain foundation model, with zero-shot cell annotation and disease prediction across species.
Single-cellLanguage model5OpennessTriFlow
9——Structure-conditioned protein sequence design, pairing a three-track architecture with discrete flow matching for fast, few-step inverse folding.
Protein69OpennessCLEF
554—Single-lead ECG foundation model pretrained on 12-lead recordings, weighting contrastive pairs by clinical risk for cardiovascular risk prediction.
Biosignals62OpennessgRNAde
3098617MRC Laboratory of Molecular Biology +1 otherDecember 1, 2025de_novo_designgenerativegraph_neural_network+5RNA inverse-folding model that generates sequences predicted to fold into a target 3D backbone, capturing non-canonical pairs and tertiary motifs.
RNA98OpennessCellHermes
30254Single-cell foundation model adapting LLaMA-3.1-8B with LoRA, recasting transcriptomes and protein interaction networks as natural-language Q&A pairs.
Single-cellRNA55OpennessRadDiff
———Retrieval-augmented diffusion model for protein inverse folding that conditions sequence generation on profiles from structurally similar homologs.
Protein27OpennessTEA
2423.8KProtein sequence encoder that maps ESM2 embeddings to a learned 20-letter alphabet for structure-quality remote homology detection at MMseqs2 speed.
Protein86Openness