University of Zurich

Microbiome world model that treats a community as a set of taxa, scoring how well each member fits and predicting community dynamics zero-shot.

Brain MRI synthesis in 3D across T1w, T2w, FLAIR and SWI, whole-brain or skull-stripped, at up to 512x512x256 voxels in 30 sampling steps.

Latent flow-matching method that repurposes protein language model embeddings to generate high-fitness protein variants without predictor guidance.

Cas9 PAM preference prediction from protein sequence with an ESM-2 backbone, extending PAM annotation to 50,308 metagenome-mined orthologs.

Patch-based 3D diffusion model that generates teravoxel-scale virtual mouse brain volumes conditioned on spatially resolved gene expression.

Compact EEG foundation model whose alternating attention separates within-channel time from across-channel space, cutting attention memory sixfold.

Spatial proteomics foundation model that embeds every marker through its protein sequence, so heterogeneous antibody panels share one representation.

3D blood vessel segmentation across CT, MRI, light-sheet microscopy and OCTA volumes, generalizing zero-shot to imaging domains absent from training.

Vision-language chat model for 3D chest CT volumes, answering free-form questions and drafting radiology report findings from a frozen 3D encoder.

De novo protein binder design pipeline that hallucinates binders through frozen AlphaFold2 weights, averaging a 46% experimental success rate.

Vision-language model for 3D chest CT that aligns whole volumes with radiology reports for zero-shot abnormality detection and case retrieval.

Virtual staining model that generates 11-marker spatially resolved protein multiplexes from routine H&E histopathology whole-slide images.