All Competitors

Every biological foundation model, evaluated and ranked by the bio.rodeo team

Showing 193216 of 217 filtered models

  • GenerRNA

    1947
    Preferred NetworksOctober 1, 2024de_novo_designfoundation_modelgenerative

    Transformer-based generative language model for de novo RNA design, pretrained on 16 million non-coding RNA sequences from RNAcentral.

    RNA
    75Openness
  • DFMDock

    557
    Johns Hopkins UniversitySeptember 27, 2024contrastive_learningdiffusiongenerative+3

    Diffusion model for protein-protein docking that unifies pose sampling and energy-based ranking, works without MSAs, and generalizes to new targets.

    Protein
    81Openness
  • moPPIt

    144
    Duke UniversityJuly 31, 2024binding_site_predictionflow_matchinggenerative+6

    De novo peptide binder design framework that targets specific motifs, including disordered regions and conserved epitopes, from target sequence alone.

    Protein
    18Openness
  • Microsoft ResearchJuly 8, 2024conformational_ensemble_generationfine_tunedflow_matching+4

    Lightweight AlphaFlow variant that fine-tunes only AlphaFold's structure module, keeping the Evoformer frozen to cut conformational sampling cost.

    Protein
    21Openness
  • Chan Zuckerberg InitiativeJuly 1, 2024autoencodercell_type_annotationde_novo_design+6

    Variational autoencoder pretrained on 74 million human single-cell transcriptomes from the CELLxGENE Census for batch correction and cell typing.

    Single-cell
    96Openness
  • ESM-3

    2.9K31313.2K
    EvolutionaryScaleJune 25, 2024foundation_modelgenerativeprotein_design+1

    Multimodal generative protein language model reasoning jointly over protein sequence, structure, and function, trained at 98B parameters.

    Protein
    27Openness
  • Microsoft ResearchMay 13, 2024cryo_emdiffusiondrug_discovery+8

    Deep learning framework predicting equilibrium distributions of molecular systems, enabling efficient ensemble generation and conformation sampling.

    Protein
    46Openness
  • Prescient Design +1 otherMay 7, 2024antibodyantibody_designde_novo_design+4

    Discrete generative model for antibody protein sequences combining MCMC walks on a smoothed energy landscape with one-step denoising jumps.

    Protein
    60Openness
  • OpenCRISPR-1

    1.2K80
    ProfluentApril 22, 2024de_novo_designdnafoundation_model+5

    AI-designed CRISPR-Cas9 gene editor generated by protein language models trained on 1.2 million CRISPR operons and shown to edit the human genome.

    Protein
    16Openness
  • AlphaFlow

    536259
    MITFebruary 7, 2024conformational_ensemble_generationfine_tunedflow_matching+4

    Protein conformational ensemble generator that fine-tunes AlphaFold 2 with flow matching, sampling protein dynamics beyond a single static structure.

    Protein
    79Openness
  • scMulan

    626
    Tsinghua UniversityJanuary 29, 2024foundation_modelgenerativelanguage_model+1

    Generative language model for single-cell transcriptomics with 368M parameters, unifying cell type annotation, batch integration, and cell generation.

    Single-cell
    48Openness
  • IMPA

    2657
    Theis LabJanuary 8, 2024autoencodercell_biologydrug_discovery+5

    Generative image perturbation autoencoder predicting cellular morphological responses to chemical and genetic perturbations from control images.

    Single-cell
    53Openness
  • Tsinghua UniversityJanuary 1, 2024diffusionfoundation_modelgenerative

    Diffusion model for synthesizing single-cell RNA-seq data, with guided generation of specific cell types, rare cells, and developmental trajectories.

    Single-cell
    60Openness
  • Chroma

    824
    Generate:BiomedicinesNovember 1, 2023diffusiongenerativegraph_neural_network+3

    Diffusion model for programmable protein design that jointly samples structures and sequences, conditioned on symmetry, shape, or text prompts.

    Protein
    53Openness
  • ProGen2

    705
    SalesforceOctober 30, 2023foundation_modelgenerativelanguage_model+1

    Protein language models from 151M to 6.4B parameters, trained on over a billion sequences for sequence generation and zero-shot fitness prediction.

    Protein
    55Openness
  • EvoDiff

    675226
    Microsoft ResearchSeptember 12, 2023cnnde_novo_designdiffusion+8

    Discrete diffusion model for protein sequence and MSA generation, enabling controllable de novo design directly in sequence space without structure.

    Protein
    84Openness
  • RadFM

    561263
    Shanghai Jiao Tong University +1 otherAugust 4, 2023disease_diagnosisfoundation_modelgenerative+7

    Radiology foundation model that reads interleaved 2D and 3D scans with text for diagnosis, visual question answering, and report generation.

    ImagingLanguage model
    84Openness
  • Med-PaLM M

    552
    Google Research +1 otherJuly 26, 2023generativegenomicshistology+9

    Google's generalist multimodal biomedical AI that encodes clinical text, medical images, and genomics with a single set of weights across 14 tasks.

    ImagingLanguage model
    25Openness
  • DNAGPT

    46
    TencentAILabHealthcareJuly 11, 2023dnafoundation_modelgenerative+1

    GPT-style DNA foundation model trained on over 200 billion base pairs of mammalian genomes for sequence generation, classification, and regression.

    DNA & Gene
    6Openness
  • TencentAILabHealthcareJuly 4, 2023cross_modality_translationfoundation_modelgenerative+5

    Generative transformer that translates single-cell transcriptomes into proteomes, inferring missing protein abundance from RNA expression alone.

    Single-cell
    33Openness
  • MedVInT

    236367
    Shanghai Jiao Tong University +1 otherMay 17, 2023generativehistologymedical_image_understanding+6

    Generative medical visual question answering model that pairs a vision encoder with a language model, trained on the 227k-pair PMC-VQA dataset.

    PathologyLanguage model
    83Openness
  • RoentGen

    88146
    Stanford UniversityNovember 23, 2022chest_radiographydata_augmentationfoundation_model+5

    Text-conditioned latent diffusion model that generates synthetic chest X-rays from free-form radiology prompts by adapting Stable Diffusion.

    ImagingLanguage model
    20Openness
  • BioGPT

    4.5K1.5K101.4K
    Microsoft Research Asia +1 otherOctober 19, 2022biomedical_literaturegenerativegpt+6

    Generative transformer pretrained on PubMed abstracts for biomedical text generation and mining, including relation extraction and question answering.

    Language model
    66Openness
  • ProtGPT2

    8698.2K
    University of BayreuthJuly 27, 2022foundation_modelgenerativeprotein_design

    Autoregressive protein language model based on GPT-2 that generates de novo protein sequences sampling unexplored regions of protein space.

    Protein
    54Openness