All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 1–24 of 217 filtered models
GPFlow
———Variable-length generative protein design across structure, sequence, motif scaffolding, and peptide co-design via a generalized Poisson flow.
Protein18OpennessIgGM2
———All-atom foundation model for immune-receptor design that predicts structures and co-designs CDR sequences for antibodies, nanobodies, and TCRs.
Protein32OpennessLYNX
9——Spatial multi-omics integration model aligning RNA, protein, metabolomics, and histology to map cell-state gradients and cell-cell interactions.
Spatial omicsSingle-cell28OpennessU-Pert
———Center for Machine Learning Research, Peking UniversityJuly 4, 2026generativeperturbation_predictionSingle-cell perturbation-response model predicting transcriptomic and cell-number changes for unseen perturbations plus inverse design.
Single-cell10OpennessStructure-based drug design language model fusing protein structural and evolutionary encoders with SAFE fragment tokens for hit-to-lead generation.
Small moleculeProtein10OpennessPep2Mol
———Diffusion model for 3D small-molecule design against protein-protein interaction sites, guided by the natural binding peptide or protein partner.
Small moleculeProtein10OpennessV3Cell
———Xinjiang Technical Institute of Physics and Chemistry +2 othersJune 24, 2026cell_biologydrug_discoverygenerative+4Vision-guided model that builds virtual 3D organoid surrogates from brightfield microscopy to predict chemical perturbation responses without omics.
ImagingPathology4Openness- Max Delbrück Center for Molecular MedicineJune 24, 2026gene_expressiongenerativerepresentation_learning+4
Supervised variational autoencoder that learns a tissue-aware latent space for bulk RNA-seq, trained on harmonized TCGA, GTEx, and ARCHS4 data.
RNA84Openness Molexar
7—17Multimodal molecular generation model for drug design, conditioned on properties, pharmacophores, protein sequences, or protein binding pockets.
Small moleculeProtein82OpennessNavigo
12——Chinese University of Hong Kong +1 otherJune 24, 2026cell_fate_engineeringflow_matchinggene_regulatory_network_inference+6Generative framework that learns a developmental vector field from scRNA-seq snapshots, coupling flow matching with molecular RNA kinetics.
Single-cellRNA44OpennessSesame
———Diffusion model that generates 3D small molecules conditioned on protein pockets and partial fragments encoded as continuous spatial density maps.
Small moleculeProtein15OpennessJEDEL
———Zero-shot generative framework that turns 3D pharmacophores into synthesis-ready DNA-encoded libraries of purchasable building blocks.
Small molecule23OpennessRNAJog
2——Autoregressive generative model that uses reinforcement learning to optimize mRNA codon sequences for MFE, CAI, and GC content.
RNA9OpennessBoltzProt-1
4.1K——De novo protein binder and nanobody design pipeline that ranks candidates by a protein-protein interaction model rather than structural confidence.
Protein11OpennessTCRDiff
7——Conditional denoising diffusion model that designs antigen-specific TCR CDR3β sequences conditioned on peptide-MHC targets and germline V-genes.
Protein75OpennessBetaInfer
———Technion – Israel Institute of Technology +2 othersJune 14, 2026generativegenomicsmolecular_evolution+4Generative transformer for phylogenetic inference that transduces sets of unaligned molecular sequences directly into Newick-format trees.
DNA & GeneProtein8OpennessMoE-Bind
2——Protein binder generator producing receptor-conditioned binders from sequence alone, using a sparse Mixture-of-Experts transformer with no 3D input.
Protein54OpennessRDiffusion
———Diffusion-based generative RNA model for de novo sequence design, conditioned on function, RNA family, structure, or binding proteins.
RNA5OpennessRNARL
———Reinforcement-learning generative framework for multi-objective RNA codon optimization that generalizes across six species and five RNA types.
RNA4OpennessGermRL
1—4Reinforcement learning framework that fine-tunes the ProGen2-OAS antibody language model with GRPO to cut germline bias in generated sequences.
Protein65OpennessHBDesigner
16——Message-passing neural network that designs buried hydrogen-bond networks onto protein backbones, combining learned placement with PyRosetta scoring.
Protein60OpennessHoloCell
———860M-parameter generative single-cell foundation model that jointly represents and generates epigenomic, transcriptomic, and proteomic modalities.
Single-cellDNA & Gene21OpennessVelocityFM
———University of Colombo School of Computing +1 otherJune 7, 2026conformational_samplingflow_matchinggenerative+4Generative protein-dynamics model that predicts short molecular dynamics trajectories with rectified flow matching over residue frames and torsions.
Protein21Openness