All Competitors

Every biological foundation model, evaluated and ranked by the bio.rodeo team

Showing 124 of 217 filtered models

  • GPFlow

    University of Illinois Urbana-ChampaignJuly 10, 2026flow_matchinggenerativemotif_scaffolding+4

    Variable-length generative protein design across structure, sequence, motif scaffolding, and peptide co-design via a generalized Poisson flow.

    Protein
    18Openness
  • IgGM2

    Tencent AI for Life Science Lab +3 othersJuly 9, 2026antibodydiffusionfoundation_model+4

    All-atom foundation model for immune-receptor design that predicts structures and co-designs CDR sequences for antibodies, nanobodies, and TCRs.

    Protein
    32Openness
  • LYNX

    9
    Columbia UniversityJuly 9, 2026cell_cell_interaction_inferencegenerativegraph_neural_network+2

    Spatial multi-omics integration model aligning RNA, protein, metabolomics, and histology to map cell-state gradients and cell-cell interactions.

    Spatial omicsSingle-cell
    28Openness
  • U-Pert

    Center for Machine Learning Research, Peking UniversityJuly 4, 2026generativeperturbation_prediction

    Single-cell perturbation-response model predicting transcriptomic and cell-number changes for unseen perturbations plus inverse design.

    Single-cell
    10Openness
  • StructureSAFE

    Purdue UniversityJuly 2, 2026foundation_modelgenerativelead_optimization+1

    Structure-based drug design language model fusing protein structural and evolutionary encoders with SAFE fragment tokens for hit-to-lead generation.

    Small moleculeProtein
    10Openness
  • Pep2Mol

    University of FloridaJune 29, 2026de_novo_designdiffusiondrug_discovery+3

    Diffusion model for 3D small-molecule design against protein-protein interaction sites, guided by the natural binding peptide or protein partner.

    Small moleculeProtein
    10Openness
  • V3Cell

    Xinjiang Technical Institute of Physics and Chemistry +2 othersJune 24, 2026cell_biologydrug_discoverygenerative+4

    Vision-guided model that builds virtual 3D organoid surrogates from brightfield microscopy to predict chemical perturbation responses without omics.

    ImagingPathology
    4Openness
  • Max Delbrück Center for Molecular MedicineJune 24, 2026gene_expressiongenerativerepresentation_learning+4

    Supervised variational autoencoder that learns a tissue-aware latent space for bulk RNA-seq, trained on harmonized TCGA, GTEx, and ARCHS4 data.

    RNA
    84Openness
  • Molexar

    717
    Peking UniversityJune 24, 2026de_novo_designdrug_designdrug_discovery+5

    Multimodal molecular generation model for drug design, conditioned on properties, pharmacophores, protein sequences, or protein binding pockets.

    Small moleculeProtein
    82Openness
  • Navigo

    12
    Chinese University of Hong Kong +1 otherJune 24, 2026cell_fate_engineeringflow_matchinggene_regulatory_network_inference+6

    Generative framework that learns a developmental vector field from scRNA-seq snapshots, coupling flow matching with molecular RNA kinetics.

    Single-cellRNA
    44Openness
  • Sesame

    Tessel BiosciencesJune 22, 2026de_novo_designdiffusiondrug_discovery+3

    Diffusion model that generates 3D small molecules conditioned on protein pockets and partial fragments encoded as continuous spatial density maps.

    Small moleculeProtein
    15Openness
  • JEDEL

    University of Southampton +1 otherJune 21, 2026de_novo_designdna_encoded_librariesdrug_discovery+6

    Zero-shot generative framework that turns 3D pharmacophores into synthesis-ready DNA-encoded libraries of purchasable building blocks.

    Small molecule
    23Openness
  • RNAJog

    2
    Shanghai Jiao Tong UniversityJune 20, 2026autoregressivecodoncodon_optimization+7

    Autoregressive generative model that uses reinforcement learning to optimize mRNA codon sequences for MFE, CAI, and GC content.

    RNA
    9Openness
  • BoltzProt-1

    4.1K
    BoltzJune 16, 2026antibodybinder_designfoundation_model+5

    De novo protein binder and nanobody design pipeline that ranks candidates by a protein-protein interaction model rather than structural confidence.

    Protein
    11Openness
  • TCRDiff

    7
    Monash UniversityJune 14, 2026antibodyde_novo_designdiffusion+5

    Conditional denoising diffusion model that designs antigen-specific TCR CDR3β sequences conditioned on peptide-MHC targets and germline V-genes.

    Protein
    75Openness
  • BetaInfer

    Technion – Israel Institute of Technology +2 othersJune 14, 2026generativegenomicsmolecular_evolution+4

    Generative transformer for phylogenetic inference that transduces sets of unaligned molecular sequences directly into Newick-format trees.

    DNA & GeneProtein
    8Openness
  • MoE-Bind

    2
    University of North BengalJune 13, 2026autoregressivede_novo_designgenerative+6

    Protein binder generator producing receptor-conditioned binders from sequence alone, using a sparse Mixture-of-Experts transformer with no 3D input.

    Protein
    54Openness
  • RDiffusion

    Zhejiang University +6 othersJune 13, 2026de_novo_designdiffusionfoundation_model+5

    Diffusion-based generative RNA model for de novo sequence design, conditioned on function, RNA family, structure, or binding proteins.

    RNA
    5Openness
  • RNARL

    Shanghai Jiao Tong University +2 othersJune 13, 2026codoncodon_optimizationgenerative+6

    Reinforcement-learning generative framework for multi-objective RNA codon optimization that generalizes across six species and five RNA types.

    RNA
    4Openness
  • GermRL

    14
    Johns Hopkins UniversityJune 11, 2026antibodyantibody_designde_novo_design+6

    Reinforcement learning framework that fine-tunes the ProGen2-OAS antibody language model with GRPO to cut germline bias in generated sequences.

    Protein
    65Openness
  • HBDesigner

    16
    Kuhlman Lab +1 otherJune 11, 2026generativegraph_neural_networkhydrogen_bond_network_design+3

    Message-passing neural network that designs buried hydrogen-bond networks onto protein backbones, combining learned placement with PyRosetta scoring.

    Protein
    60Openness
  • HoloCell

    Beijing Zhongguancun AcademyJune 11, 2026cross_modal_generationdiffusionepigenomics+7

    860M-parameter generative single-cell foundation model that jointly represents and generates epigenomic, transcriptomic, and proteomic modalities.

    Single-cellDNA & Gene
    21Openness
  • Promera

    83
    MIT +1 otherJune 10, 2026antibodybinder_designdiffusion+5

    Unified all-atom generative model for biomolecular structure prediction, binder filtering, and controllable protein and nanobody design.

    Protein
    61Openness
  • VelocityFM

    University of Colombo School of Computing +1 otherJune 7, 2026conformational_samplingflow_matchinggenerative+4

    Generative protein-dynamics model that predicts short molecular dynamics trajectories with rectified flow matching over residue frames and torsions.

    Protein
    21Openness