Microsoft Research

Distilled whole-slide pathology foundation model pairing a 22M-parameter ViT-S tile encoder with a LongNet slide encoder for cohort-scale analysis.

Spatial proteomics prediction from routine H&E slides, generating 21-channel virtual multiplex immunofluorescence maps of the tumor microenvironment.

Generative microscopy foundation model that synthesizes in-silico fluorescence images of protein subcellular localization from amino-acid sequence.

Vision-language encoders for chest CT that align 3D volumes with radiology reports using contrastive, report-generation, and masked-image objectives.

Protein language models trained on billions of natural and synthetic sequences for de novo design and zero-shot mutation-effect prediction.

Multimodal slide-level pathology foundation model trained by clinical-dialogue supervision on 2.3M whole-slide images and 14M Q&A pairs.

Generative design of protease substrates, producing 10-mer peptides conditioned on a target cleavage profile across 18 matrix metalloproteinases.

Chest X-ray vision-language model that drafts the findings section of a radiology report, at 7B parameters small enough to run on a single GPU.

Autoregressive genomic foundation models from 20M to 1B parameters that solve ten DNA tasks at once and map sequences to text and images.

Biomedical imaging foundation model that segments, detects, and recognizes structures across nine modalities from natural language prompts.

Protein language model that captures short- and long-range residue co-evolution through a dual pre-training objective, at 3B parameters.

Multimodal protein function annotation that scores a sequence against free-text descriptions, including GO and EC labels unseen during training.

Medical imaging embedding model spanning X-ray, CT, MRI, dermoscopy, OCT, fundus, ultrasound, histopathology and mammography in one encoder.

Enzyme catalytic pocket design conditioned on a reaction: substrate and product in, pocket backbone, sequence, and EC class out.

Lightweight AlphaFlow variant that fine-tunes only AlphaFold's structure module, keeping the Evoformer frozen to cut conformational sampling cost.

Microsoft Research multimodal LLM for grounded chest X-ray report generation, localizing each described finding with bounding boxes on the image.

Whole-slide histopathology foundation model pretrained on 1.3 billion image tiles from 171,189 clinical slides spanning 31 tissue types.

Deep learning framework predicting equilibrium distributions of molecular systems, enabling efficient ensemble generation and conformation sampling.

Radiology-specific multimodal LLM that generates the findings section of a chest X-ray report from a frontal image, pairing RAD-DINO with Vicuna-7B.

Discrete diffusion model for protein sequence and MSA generation, enabling controllable de novo design directly in sequence space without structure.

Antibody CDR design framework pairing a pretrained antibody language model with a hierarchical graph neural network for one-shot CDR generation.

Biomedical vision-language assistant for question answering on radiology and pathology images, adapted from LLaVA on PubMed Central captions.

Biomedical vision-language model trained contrastively on 15M PubMed Central figure-caption pairs for zero-shot classification, retrieval, and VQA.

Generative transformer pretrained on PubMed abstracts for biomedical text generation and mining, including relation extraction and question answering.

Protein language model family built on CNNs rather than transformers, matching transformer quality while scaling linearly with sequence length.

Biomedical language model pretrained from scratch on PubMed abstracts with a WordPiece vocabulary derived from biomedical text rather than the web.