All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 1–24 of 25 filtered models
Chreode
———University of North Carolina at Chapel Hill +2 othersMay 27, 2026cell_fate_predictioncrispr_perturbationdevelopmental_trajectory_modeling+8A cell world model pretrained on a 2.4M-cell mouse embryonic atlas that predicts one-step transcriptional state transitions and transfers to perturbation prediction.
Single-cell26OpennessDoFormer
———A causal multimodal Transformer that embeds the do-operator within attention to predict single-cell responses to gene perturbations, including unseen ones.
Single-cell8OpennessscPert
———A multi-modal Transformer that fuses LLM gene embeddings with biological knowledge graphs to predict single-cell transcriptomic responses to genetic perturbations.
Single-cell14OpennessHyperMap
———Meta-learning framework that transfers perturbation responses across cell lines, donors, and drugs from a few seed perturbations, using one-eighth the parameters of typical single-cell foundation models.
Single-cell11OpennessRVQ-Alpha
———A Qwen3-4B language model that reads and reasons over single cells by tokenizing scRNA-seq with residual vector quantization and training with verifiable reinforcement learning.
Single-cell4OpennessscLong
21——Billion-parameter single-cell foundation model performing full self-attention across all 28,000 human genes, integrating Gene Ontology priors via GCN for long-range gene context capture in transcriptomics.
Single-cell29OpennessX-Cell
954—4.9 billion parameter diffusion language model for predicting genome-wide genetic perturbation responses, trained on the largest CRISPRi Perturb-seq dataset built to date.
Single-cell20OpennessPerturbGen
21——Generative single-cell foundation model trained on 100M+ transcriptomes that predicts how genetic perturbations reshape cellular trajectories over time.
Single-cell72OpennessPerturbDiff
435—Functional diffusion model that predicts single-cell perturbation responses by generating over distributions embedded in a Hilbert space, capturing population-level response variability.
Single-cell51OpennessA discrete-diffusion generative model that operates directly on single-cell gene counts, enabling unconditional and perturbation-conditioned scRNA-seq generation.
Single-cell10OpennessCLM-X
———Hangzhou Institute of Medicine, CASFebruary 18, 2026batch_correctioncell_biologycell_type_annotation+6A multimodal single-cell foundation model with a multiway Transformer that jointly models scRNA-seq and scATAC-seq, including RNA-only, ATAC-only, and paired inputs.
Single-cell4OpennessscDFM
395—Distributional flow matching model for single-cell perturbation prediction that models population-level expression shifts using a graph-aware differential-attention transformer.
Single-cell54OpennessscDiVa
———A masked discrete-diffusion single-cell foundation model that jointly generates cell identity and expression, pre-trained on 59 million cells.
Single-cell6OpennessSTACK
1368—Single-cell foundation model using tabular attention over context cells to enable zero-shot representation and in-context prediction of arbitrary perturbations.
Single-cell33OpennessA pair of spatially aware transcriptomic foundation models (50um-Local and 250um-Extended) for multi-scale analysis of spot-resolution cancer spatial transcriptomes.
Spatial omics12OpennessscLDM.CD4
7—9A fine-tuned scLDM variant trained on 14.5 million CD4+ T cells for counterfactual prediction of single-gene perturbation effects in immune cells.
Single-cell75OpennessscLDM
525—A scalable latent diffusion model for generating realistic single-cell gene expression profiles, using a permutation-invariant VAE and flow-matching diffusion transformer.
Single-cell75OpennessGREmLN
37——A graph-signal-processing foundation model that embeds gene regulatory network structure directly into its attention mechanism for parameter-efficient single-cell transcriptomics.
Single-cell80OpennessSTATE
59397115Transformer model for predicting cellular responses to perturbations across diverse cell contexts, trained on over 267 million human single-cell profiles.
Single-cell21OpennessscGenePT
3012—A single-cell perturbation model that augments scGPT with gene-level language embeddings from NCBI, UniProt, and Gene Ontology to improve multi-gene perturbation prediction.
Single-cell90OpennessGEARS
369335—Geometric deep learning model that predicts transcriptional responses to multi-gene perturbations by integrating single-cell RNA-seq with a gene-gene knowledge graph.
Single-cell68Openness