All Competitors

Every biological foundation model, evaluated and ranked by the bio.rodeo team

Showing 124 of 25 filtered models

  • Chreode

    University of North Carolina at Chapel Hill +2 othersMay 27, 2026cell_fate_predictioncrispr_perturbationdevelopmental_trajectory_modeling+8

    A cell world model pretrained on a 2.4M-cell mouse embryonic atlas that predicts one-step transcriptional state transitions and transfers to perturbation prediction.

    Single-cell
    26Openness
  • DoFormer

    Columbia University +1 otherMay 4, 2026causal_inferencefoundation_modelgene_expression+3

    A causal multimodal Transformer that embeds the do-operator within attention to predict single-cell responses to gene perturbations, including unseen ones.

    Single-cell
    8Openness
  • scPert

    Zhejiang University School of MedicineApril 28, 2026drug_discoveryfoundation_modelgene_expression+4

    A multi-modal Transformer that fuses LLM gene embeddings with biological knowledge graphs to predict single-cell transcriptomic responses to genetic perturbations.

    Single-cell
    14Openness
  • HyperMap

    University of California San Diego +1 otherApril 27, 2026crisprdrug_discoveryfew_shot+7

    Meta-learning framework that transfers perturbation responses across cell lines, donors, and drugs from a few seed perturbations, using one-eighth the parameters of typical single-cell foundation models.

    Single-cell
    11Openness
  • RVQ-Alpha

    Guangzhou National LaboratoryApril 23, 2026cell_type_annotationlanguage_modelmultimodal+5

    A Qwen3-4B language model that reads and reasons over single cells by tokenizing scRNA-seq with residual vector quantization and training with verifiable reinforcement learning.

    Single-cell
    4Openness
  • scLong

    21
    Chinese Academy of SciencesApril 1, 2026batch_integrationcancer_drug_responsecell_type_annotation+7

    Billion-parameter single-cell foundation model performing full self-attention across all 28,000 human genes, integrating Gene Ontology priors via GCN for long-range gene context capture in transcriptomics.

    Single-cell
    29Openness
  • X-Cell

    954
    Xaira TherapeuticsMarch 17, 2026crispr_perturbationdiffusionfoundation_model+5

    4.9 billion parameter diffusion language model for predicting genome-wide genetic perturbation responses, trained on the largest CRISPRi Perturb-seq dataset built to date.

    Single-cell
    20Openness
  • PerturbGen

    21
    Wellcome Sanger InstituteMarch 5, 2026cell_biologyfoundation_modelgene_expression+6

    Generative single-cell foundation model trained on 100M+ transcriptomes that predicts how genetic perturbations reshape cellular trajectories over time.

    Single-cell
    72Openness
  • MilaFebruary 23, 2026diffusiongene_expressiongenerative+3

    Functional diffusion model that predicts single-cell perturbation responses by generating over distributions embedded in a Hilbert space, capturing population-level response variability.

    Single-cell
    51Openness
  • University of BristolFebruary 19, 2026data_generationdiffusionfoundation_model+4

    A discrete-diffusion generative model that operates directly on single-cell gene counts, enabling unconditional and perturbation-conditioned scRNA-seq generation.

    Single-cell
    10Openness
  • CLM-X

    Hangzhou Institute of Medicine, CASFebruary 18, 2026batch_correctioncell_biologycell_type_annotation+6

    A multimodal single-cell foundation model with a multiway Transformer that jointly models scRNA-seq and scATAC-seq, including RNA-only, ATAC-only, and paired inputs.

    Single-cell
    4Openness
  • scDFM

    395
    Westlake UniversityFebruary 6, 2026flow_matchinggene_expressiongenerative+4

    Distributional flow matching model for single-cell perturbation prediction that models population-level expression shifts using a graph-aware differential-attention transformer.

    Single-cell
    54Openness
  • scDiVa

    Renmin University of ChinaFebruary 3, 2026batch_integrationcell_type_annotationdiffusion+6

    A masked discrete-diffusion single-cell foundation model that jointly generates cell identity and expression, pre-trained on 59 million cells.

    Single-cell
    6Openness
  • TwinCell

    1
    DeepLifeJanuary 29, 2026cancerfoundation_modelgene_regulation+5

    Large causal cell model trained on cancer perturbation data that generalizes zero-shot to patient-derived cells for therapeutic target prioritization.

    Single-cell
    19Openness
  • STACK

    1368
    Arc Institute +1 otherJanuary 9, 2026cell_representationfoundation_modelin_context_learning+5

    Single-cell foundation model using tabular attention over context cells to enable zero-shot representation and in-context prediction of arbitrary perturbations.

    Single-cell
    33Openness
  • Baylor College of MedicineDecember 25, 2025cancerfoundation_modelligand_target_inference+7

    A pair of spatially aware transcriptomic foundation models (50um-Local and 250um-Extended) for multi-scale analysis of spot-resolution cancer spatial transcriptomes.

    Spatial omics
    12Openness
  • Chan Zuckerberg InitiativeNovember 4, 2025autoencodercell_biologydiffusion+8

    A fine-tuned scLDM variant trained on 14.5 million CD4+ T cells for counterfactual prediction of single-gene perturbation effects in immune cells.

    Single-cell
    75Openness
  • scLDM

    525
    Chan Zuckerberg InitiativeNovember 4, 2025autoencodercell_biologydata_augmentation+8

    A scalable latent diffusion model for generating realistic single-cell gene expression profiles, using a permutation-invariant VAE and flow-matching diffusion transformer.

    Single-cell
    75Openness
  • GREmLN

    37
    Chan Zuckerberg Initiative +2 othersJuly 9, 2025cell_type_annotationchromatinfoundation_model+6

    A graph-signal-processing foundation model that embeds gene regulatory network structure directly into its attention mechanism for parameter-efficient single-cell transcriptomics.

    Single-cell
    80Openness
  • STATE

    59397115
    Arc InstituteJune 27, 2025drug_discoveryfoundation_modelgene_expression+4

    Transformer model for predicting cellular responses to perturbations across diverse cell contexts, trained on over 267 million human single-cell profiles.

    Single-cell
    21Openness
  • scGenePT

    3012
    Chan Zuckerberg InitiativeOctober 28, 2024foundation_modelgene_expressionmultimodal+4

    A single-cell perturbation model that augments scGPT with gene-level language embeddings from NCBI, UniProt, and Gene Ontology to improve multi-gene perturbation prediction.

    Single-cell
    90Openness
  • IMPA

    2649
    Theis LabJanuary 8, 2024autoencodercell_biologydrug_discovery+5

    Generative image perturbation autoencoder that predicts cellular morphological responses to chemical and genetic perturbations using untreated cell images as input.

    Single-cell
    53Openness
  • GEARS

    369335
    SNAP (Stanford)August 17, 2023crispr_screen_analysisgenetic_interaction_predictiongenomics+5

    Geometric deep learning model that predicts transcriptional responses to multi-gene perturbations by integrating single-cell RNA-seq with a gene-gene knowledge graph.

    Single-cell
    68Openness
  • CPA

    146287
    Theis LabApril 15, 2021autoencoderdrug_response_modelinggenerative+5

    Compositional Perturbation Autoencoder that predicts single-cell transcriptional responses to unseen drug combinations and doses using disentangled latent representations.

    Single-cell
    78Openness