Wellcome Sanger Institute

Tissue reconstruction model placing dissociated single cells into spatial coordinates by predicting pairwise distances in a learned embedding space.

Spatial transcriptomics foundation model giving gene-, cell- and neighborhood-scale embeddings zero-shot, plus in-silico gene knockout in tissue.

Cell type annotation model mapping human single-cell and spatial transcriptomes onto one hierarchical typology of 381 types across 23 tissues.

Generative single-cell foundation model trained on 100M+ transcriptomes that predicts how genetic perturbations reshape cell trajectories over time.

Multi-modal contrastive model that aligns H&E histopathology with spatial transcriptomics across tissue scales to predict gene expression from images.