All Competitors

Designs RNA and DNA aptamers against protein targets by backpropagating binding and anti-binding objectives through a frozen all-atom predictor.

DARPin binder design constrained to the ankyrin-repeat consensus grammar, pairing a fine-tuned inverse-folding model with two structure oracles.

Antibody CDR design model post-trained by on-policy distillation, cutting RAbD CDR-H3 backbone RMSD from 2.37 Å to 1.95 Å.

De novo protein binder and nanobody design pipeline that ranks candidates by a protein-protein interaction model rather than structural confidence.

Unified all-atom generative model for biomolecular structure prediction, binder filtering, and controllable protein and nanobody design.

De novo nanobody design generating epitope-targeted VHH binders from a target sequence, with only 14-50 candidates sent for experimental testing.

Structure-prediction and design engine that turns ESMC sequence representations into all-atom 3D structures of proteins and biomolecular complexes.

Protein structure prediction and binder design in a single generative step, replacing AlphaFold3's iterative diffusion sampling with one forward pass.

All-atom protein co-design model that generates sequence and structure together in one unified diffusion process, aimed at hard binder design.

Protein inverse folding model aligning ProteinMPNN by multi-objective preference optimization to improve developability without losing fold fidelity.

Full-atom SE(3)-equivariant diffusion model that inpaints binding interfaces to design proteins that bind DNA, RNA, and small molecules.

De novo protein binder design suite from ByteDance pairing diffusion and hallucination generators with confidence-based filtering of designs.

All-atom generative model for de novo protein and peptide binder design against diverse biomolecular targets, wet-lab validated across 26 targets.

Retrieval-augmented latent diffusion model for protein binder design, retrieving interfaces in a shared latent space across peptides and antibodies.

Protein binder design model post-trained from a multimodal protein language model to bind proteins, peptides, small molecules, and nucleic acids.

All-atom protein structure diffusion models for motif scaffolding and hotspot-conditioned complex generation, at 22M parameters.

Protein language model trained with masked diffusion, unifying representation learning and generative design in one 650M-parameter model.

De novo protein binder design that recasts structure-predictor confidence as an energy function, replacing ipTM as the hallucination objective.

De novo protein design model using flow matching for binder, motif scaffolding, and symmetric generation, with wet-lab-validated binders.

Protein binder design that inverts the frozen Boltz-1 all-atom predictor, targeting small molecules, nucleic acids, metals, and modified residues.

Generative de novo antibody design system jointly modeling sequence and all-atom structure, refined by scaling test-time compute.

Binder motif prediction from receptor structure alone, mapping 14 functional-group types across a protein surface as reusable interaction profiles.

De novo cyclic peptide binder design against a protein target, chaining a cyclized diffusion sampler, sequence design and structure prediction.