Nonprofit

Biohub

A nonprofit research organization pairing frontier AI with imaging, cell biology, and protein science, on a mission to cure or prevent all disease.

Location: San Francisco, CA
Website
5 models(3 Protein, 2 Single-cell, 1 DNA & Gene)

Models (5)

DanioDecima

Biohub / Chan Zuckerberg Biohub

Released May 29, 2026

Zebrafish sequence-to-function model predicting cell-type-specific gene expression from DNA sequence across embryonic development.

DNA & GeneSingle-cell

ESMFold2

Biohub

Released May 27, 2026

8275.9K2.9K

Structure-prediction and design engine that turns ESMC sequence representations into all-atom 3D structures of proteins and biomolecular complexes.

Protein

ESMC

Biohub

Released May 27, 2026

82.1M2.9K

Protein language model trained on roughly 2.8 billion sequences, forming the representation core of Biohub's world model of protein biology.

Protein

DoFormer

Columbia University / Biohub / Chan Zuckerberg Biohub New York

Released May 4, 2026

168

Causal multimodal transformer that embeds the do-operator in attention to predict single-cell gene expression under unseen genetic perturbations.

Single-cell

DecoderTCR

Biohub / University of Chicago

Released February 4, 2026

7

Masked language model for T-cell receptor and peptide-MHC binding prediction, with compositional pretraining and non-autoregressive decoding.

Protein