Macao Polytechnic University

Sequence-only latent diffusion model that designs target-specific peptide binders, cascaded with an affinity classifier through joint optimization.

Single-cell multi-omics foundation model whose three-stage pretraining and distillation yield RNA-and-ATAC-aware embeddings from RNA-only input.

Species-conditioned codon language model that jointly reads 5'UTRs, coding sequence, and RNA secondary structure to design native-like genes.

Peptide toxicity classification that fuses ESM-2 embeddings with an ESMFold-predicted residue contact graph read by a graph transformer.

Sequence-only peptide toxicity prediction, pairing a fine-tuned ESM-2 backbone with a bidirectional LSTM and focal loss for rare toxic peptides.

Cyclic peptide binder design by Monte Carlo tree search over sequence space, scored by predicted confidence of the peptide-target complex fold.

Cell Painting image encoder that turns whole-slide multi-channel microscopy into morphological profiles in one pass, with no cell segmentation step.

Cyclic peptide structure prediction for sequences carrying unnatural amino acids, adding atom-level features and cyclization-aware position encoding.

De novo cyclic peptide binder design against a protein target, chaining a cyclized diffusion sampler, sequence design and structure prediction.

Structure-based molecular design that samples a quantum electron cloud in the protein pocket, then decodes it into ligands with a Llama-style model.

Vision-language model for annotation-free pathology localization, marking the finding a text prompt names in X-ray, histology and fundus images.