ByteDance Seed

All-atom protein co-design model that generates sequence and structure together in one unified diffusion process, aimed at hard binder design.

De novo protein binder design suite from ByteDance pairing diffusion and hallucination generators with confidence-based filtering of designs.

Simplex diffusion model for discrete sequence generation, with released checkpoints for DNA enhancer design and de novo protein sequence design.

Structure-based drug design framework pairing pharmacophore-guided latent diffusion with training-free, pocket-aware evolutionary optimization.

Cyclic peptide design conditioned on target protein structure, generating all four cyclization types via all-atom, all-bond harmonic SDE modeling.

Protein conformation and dynamics generation from MD data, sampling trajectories, independent ensembles, and interpolations between two known states.

All-atom generative model for protein complexes that designs multi-chain binders from scratch and performs multimer folding and inverse folding.

Multimodal diffusion protein language model co-generating sequence and structure. Bit-level structure supervision cuts folding RMSD from 5.52 to 2.36.

Generative foundation model for cryo-EM density maps using flow matching, enabling zero-shot denoising, map sharpening, and missing wedge restoration.