All Competitors

Every biological foundation model, evaluated and ranked by the bio.rodeo team

Showing 4972 of 217 filtered models

  • Carbon

    2006.4K
    Hugging Face +2 othersMay 1, 2026dnafoundation_modelgenerative+3

    Autoregressive DNA foundation model for variant effect prediction, using 6-mer tokenization to match Evo2-7B win rates at far higher throughput.

    DNA & Gene
    93Openness
  • CoMole

    University of Notre DameMay 1, 2026de_novo_designdiffusiondrug_discovery+7

    Motif-aware graph diffusion model for controllable molecular generation that adapts to unseen properties by learning a lightweight task embedding.

    Small molecule
    23Openness
  • Phoenix

    Helmholtz Munich +1 otherApril 29, 2026cell_type_annotationflow_matchingfoundation_model+6

    Virtual spatial transcriptomics foundation model predicting pan-cancer, spatially-resolved single-cell gene expression from H&E histology slides.

    PathologySpatial omics
    8Openness
  • MIMIC

    37
    Polymathic AIApril 27, 2026foundation_modelgenerativegenomics+6

    Generative multimodal foundation model spanning DNA, RNA, and protein, with any-to-any inference across genome, transcriptome, and proteome.

    RNAProteinDNA & Gene
    16Openness
  • GenNA

    Zhejiang UniversityApril 24, 2026de_novo_designfoundation_modelgenerative+5

    Autoregressive nucleotide-and-text foundation model generating DNA and RNA sequences from natural-language prompts that name species and function.

    DNA & GeneRNA
    16Openness
  • AF2Dock

    151
    Johns Hopkins University +1 otherApril 24, 2026antibodyflow_matchinggenerative+5

    Protein-protein docking model adapting AlphaFold-Multimer with a docking module and flow-matching training to assemble subunits without MSAs.

    Protein
    77Openness
  • Stanford UniversityApril 24, 2026bertde_novo_designdiffusion+5

    110M-parameter RNA language model that designs sequences from secondary structure, motif, and Gene Ontology constraints via discrete diffusion.

    RNA
    48Openness
  • MMPT-FM

    3
    Merck & Co. +1 otherApril 20, 2026analog_designdrug_discoveryfoundation_model+2

    Chemical language model that generates matched molecular pair transformations from SMILES and SMARTS to design medicinal-chemistry analogs.

    Small moleculeLanguage model
    82Openness
  • University of VirginiaApril 19, 2026diffusiongenerativegraph_neural_network+5

    RNA inverse folding framework pairing a graph neural network predictor with a diffusion model, designing sequences from self-contained RNA units.

    RNA
    17Openness
  • SMILE

    Johns Hopkins UniversityApril 17, 2026diffusiongenerativehistology+2

    Schrödinger-bridge diffusion model for virtual multiplex staining, translating routine H&E histology into multiplex immunohistochemistry images.

    Pathology
    8Openness
  • LAAS-CNRS +1 otherApril 16, 2026conditional_generationconformational_ensemblesde_novo_design+6

    Encoder-decoder Transformer that generates intrinsically disordered protein sequences conditioned on target conformational-ensemble descriptors.

    Protein
    10Openness
  • UC BerkeleyApril 16, 2026de_novo_designdrug_discoverygenerative+4

    Molecular linker design model fine-tuned from Llama 3 that emits PROTAC and fragment linkers as SMILES from natural-language geometry prompts.

    Small molecule
    27Openness
  • Germinal

    27234
    Stanford University +1 otherApril 15, 2026antibodyde_novo_designgenerative+3

    Generative pipeline for epitope-targeted de novo antibody (nanobody) CDR design that yields nanomolar binders from only dozens of designs per antigen.

    Protein
    37Openness
  • xVERSE

    Duke UniversityApril 14, 2026batch_effect_correctionfoundation_modelgenerative+5

    Transcriptomics-native single-cell foundation model that learns batch-invariant cell representations and probabilistically generates virtual cells.

    Single-cell
    10Openness
  • ByteDance AI LabApril 8, 2026antibodyantibody_designde_novo_design+6

    464M-parameter structure prediction and design model that improves antibody-antigen complex accuracy over Protenix-v1 and adds generative VHH design.

    Protein
    81Openness
  • DISCO

    2103
    FutureHouse +2 othersApril 6, 2026all_atomcofactorde_novo_design+9

    Multimodal diffusion model that co-designs protein sequence and 3D structure around cofactors and small molecules for de novo heme enzyme design.

    Protein
    70Openness
  • MuPD

    Stanford UniversityApril 4, 2026data_augmentationdiffusion_transformerfoundation_model+7

    Diffusion-transformer pathology model embedding H&E histology, RNA profiles, and clinical text in a latent space for zero-shot cross-modal synthesis.

    PathologySpatial omics
    15Openness
  • Cold Spring Harbor LaboratoryApril 1, 2026de_novo_designdiffusiongene_expression+5

    Discrete diffusion model that designs regulatory DNA with tunable cell-type-specific activity and learns activity-predictive representations.

    DNA & Gene
    49Openness
  • Human Protein Atlas +1 otherMarch 31, 2026diffusionfoundation_modelgenerative+4

    Generative imaging model simulating single-cell fluorescence microscopy for all 12,800 human proteins in the Human Protein Atlas.

    Imaging
    51Openness
  • EnzyGen2

    30
    Carnegie Mellon UniversityMarch 31, 2026de_novo_designenzyme_designfoundation_model+5

    Protein foundation model for de novo enzyme design that co-designs sequence and 3D structure under small-molecule ligand guidance, at 730M parameters.

    ProteinSmall molecule
    89Openness
  • CLOP-DiT

    Third Military Medical UniversityMarch 30, 2026contrastive_learningdata_augmentationdiffusion+7

    Generates single-cell transcriptomes from structured biological metadata via contrastive language-omics pretraining and a diffusion transformer.

    Single-cell
    10Openness
  • DAMO AcademyMarch 26, 2026diffusionfoundation_modelgene_expression+4

    Virtual cell model using masked discrete diffusion over the whole transcriptome to simulate scRNA-seq perturbation responses across tissues.

    Single-cell
    21Openness
  • IDPForge

    162
    Chinese Academy of SciencesMarch 25, 2026conformational_ensembleconformational_ensemble_generationdiffusion+7

    Protein-language diffusion model generating all-atom conformational ensembles for intrinsically disordered proteins and disordered regions.

    Protein
    29Openness
  • ProAR

    Peking UniversityMarch 21, 2026autoregressiveconformational_samplinggenerative+4

    Autoregressive generative model for protein molecular dynamics that emits flexible-length trajectories frame by frame with anti-drifting sampling.

    Protein
    19Openness