All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 25–48 of 118 filtered models
resLens
—3—Genomic language models fine-tuned to detect and classify antibiotic resistance genes, catching divergent ARGs that reference alignment misses.
DNA & Gene11OpennessevoCancerGPT
———Single-cell foundation model that forecasts how cancer cells evolve, autoregressively generating future gene expression from prior cell states.
Single-cell11OpennessFrustrAI-Seq
71—Helmholtz MunichFebruary 5, 2026frustration_predictionintrinsically_disordered_regionsprotein_function_annotation+4Protein language model that predicts per-residue local energetic frustration directly from sequence, covering whole proteomes and disordered regions.
Protein78OpennessFoldVision
———Structure-based protein encoder that voxelizes every heavy atom into a 3D grid, learning orientation-robust representations for protein function.
Protein20OpennessProtProfileMD
363—LoRA adapter on ProstT5 predicting per-residue distributions over Foldseek 3Di tokens, capturing conformational flexibility from MD trajectories.
Protein93OpennessAQAffinity
—16—Structure-free protein-ligand binding affinity predictor built on OpenFold3 that scores potency from a protein sequence and a ligand SMILES string.
ProteinSmall molecule64OpennessGenerative transformer for ancestral protein sequence reconstruction that needs no multiple sequence alignment or phylogenetic tree as input.
Protein4OpennessMetagenBERT
———Annotation-free metagenome embedding pipeline that encodes raw DNA reads with genomic language models and pools them via FAISS k-means clustering.
DNA & Gene22OpennessPeptiVerse
———University of Pennsylvania +1 otherJanuary 3, 2026binding_affinity_predictiondrug_discoverygradient_boosting+4Peptide developability predictor scoring solubility, permeability, toxicity, and binding from amino-acid sequences or chemically modified SMILES.
ProteinSmall molecule81OpennessSpatial transcriptomics language model that reads tissue as spatial sentences to simulate cell profiles and run in silico perturbations.
Spatial omicsSingle-cell53OpennessFlexiFlow
—1—Flow-matching model that jointly samples 3D de novo molecules and several low-energy conformers, extending to pocket-conditioned ligand design.
Small moleculeProtein19OpennessPuget
———Gene expression prediction model combining DNA sequence with Hi-C contact maps to capture 3D chromatin looping behind cell-type-specific expression.
DNA & Gene8OpennessMethylAI
7——Cross-species-pretrained CNN that predicts single-CpG DNA methylation from genomic sequence and interprets the cis-regulatory motifs that govern it.
DNA & Gene64OpennessSHEST
1——Samsung Advanced Institute for Health Sciences and Technology +2 othersNovember 19, 2025cell_type_annotationgene_expressionhistology+5Histopathology model that predicts single-cell type composition and reconstructs spatial gene expression from H&E slides, with no molecular assay.
PathologySpatial omics16OpennessscLDM.CD4
9—198Single-cell latent diffusion model fine-tuned on 14.5 million CD4+ T cells to simulate transcriptomic effects of single-gene perturbations.
Single-cell75OpennessVariantFormer
322—Hierarchical transformer with 1.2 billion parameters that predicts personalized gene expression from diploid genomes for variant effect prediction.
DNA & Gene68OpennessStructure-based conformational B-cell epitope predictor that scores local antigen surface patches with ESM-2 embeddings and an ensemble MLP.
Protein12OpennessEnzyControl
103—Enzyme backbone design model that adds substrate and catalytic-site control to a pretrained SE(3) flow-matching generator via a lightweight adapter.
Protein86Openness- Verily Life SciencesOctober 24, 2025cross_attentiondisease_risk_predictionelectronic_health_records+7
Multimodal EHR foundation model that fuses polygenic risk scores into a GPT-2-style backbone by cross-attention for zero-shot disease risk prediction.
Language modelDNA & Gene8Openness Sequence-based binding site predictor spanning protein-DNA, protein-RNA, protein-protein, and antibody-antigen interfaces via a fine-tuned ProtT5.
Protein23OpennessNyxBind
1—2Hong Kong University of Science and TechnologyOctober 21, 2025bertbinding_site_predictioncontrastive_learning+5Transcription factor binding site prediction model that refines a DNABERT-2 backbone with contrastive learning across diverse TFBS types.
DNA & Gene40OpennessPepTron
1311—Flow-matching model that predicts protein conformational ensembles across the order-disorder continuum, from folded domains to disordered chains.
Protein91Opennesspeleke-1
8—13Suite of large language models fine-tuned with LoRA to generate antigen-targeted antibody Fv sequences from an antigen and its epitope.
Protein74Openness