All Competitors

Every biological foundation model, evaluated and ranked by the bio.rodeo team

Showing 2548 of 118 filtered models

  • ESMRank

    TIGEMFebruary 26, 2026deep_mutational_scanningproteomicsrepresentation_learning+3

    Learning-to-rank variant effect predictor that aligns overlapping deep mutational scanning assays into an assay-agnostic tolerance measure.

    Protein
    10Openness
  • resLens

    3
    George Washington UniversityFebruary 16, 2026genomicslanguage_modelmetagenomics+3

    Genomic language models fine-tuned to detect and classify antibiotic resistance genes, catching divergent ARGs that reference alignment misses.

    DNA & Gene
    11Openness
  • evoCancerGPT

    Dana-Farber Cancer InstituteFebruary 14, 2026cancerfoundation_modelgene_expression+5

    Single-cell foundation model that forecasts how cancer cells evolve, autoregressively generating future gene expression from prior cell states.

    Single-cell
    11Openness
  • Helmholtz MunichFebruary 5, 2026frustration_predictionintrinsically_disordered_regionsprotein_function_annotation+4

    Protein language model that predicts per-residue local energetic frustration directly from sequence, covering whole proteomes and disordered regions.

    Protein
    78Openness
  • FoldVision

    Heinrich Heine University DüsseldorfJanuary 23, 2026cnndrug_discoveryenzymes+5

    Structure-based protein encoder that voxelizes every heavy atom into a 3D grid, learning orientation-robust representations for protein function.

    Protein
    20Openness
  • Helmholtz Munich +2 othersJanuary 22, 2026language_modelmolecular_dynamicsproteomics+5

    LoRA adapter on ProstT5 predicting per-residue distributions over Foldseek 3Di tokens, capturing conformational flexibility from MD trajectories.

    Protein
    93Openness
  • AQAffinity

    16
    SandboxAQJanuary 20, 2026binding_affinitydiffusiondrug_discovery+3

    Structure-free protein-ligand binding affinity predictor built on OpenFold3 that scores potency from a protein sequence and a ligand SMILES string.

    ProteinSmall molecule
    64Openness
  • Tel Aviv UniversityJanuary 18, 2026ancestral_sequence_reconstructiongenerativemolecular_evolution+4

    Generative transformer for ancestral protein sequence reconstruction that needs no multiple sequence alignment or phylogenetic tree as input.

    Protein
    4Openness
  • MetagenBERT

    MetagenBERT AuthorsJanuary 5, 2026bertdnaembeddings+5

    Annotation-free metagenome embedding pipeline that encodes raw DNA reads with genomic language models and pools them via FAISS k-means clustering.

    DNA & Gene
    22Openness
  • PeptiVerse

    University of Pennsylvania +1 otherJanuary 3, 2026binding_affinity_predictiondrug_discoverygradient_boosting+4

    Peptide developability predictor scoring solubility, permeability, toxicity, and binding from amino-acid sequences or chemically modified SMILES.

    ProteinSmall molecule
    81Openness
  • Carnegie Mellon UniversityNovember 27, 2025gene_expressiongenerativelanguage_model+4

    Spatial transcriptomics language model that reads tissue as spatial sentences to simulate cell profiles and run in silico perturbations.

    Spatial omicsSingle-cell
    53Openness
  • FlexiFlow

    1
    AstraZeneca +4 othersNovember 21, 2025conformer_generationde_novo_designdrug_discovery+7

    Flow-matching model that jointly samples 3D de novo molecules and several low-energy conformers, extending to pocket-conditioned ligand design.

    Small moleculeProtein
    19Openness
  • Puget

    University of WashingtonNovember 20, 2025chromatindnafoundation_model+6

    Gene expression prediction model combining DNA sequence with Hi-C contact maps to capture 3D chromatin looping behind cell-type-specific expression.

    DNA & Gene
    8Openness
  • MethylAI

    7
    Guangzhou National LaboratoryNovember 20, 2025cnndnaepigenetics+6

    Cross-species-pretrained CNN that predicts single-CpG DNA methylation from genomic sequence and interprets the cis-regulatory motifs that govern it.

    DNA & Gene
    64Openness
  • SHEST

    1
    Samsung Advanced Institute for Health Sciences and Technology +2 othersNovember 19, 2025cell_type_annotationgene_expressionhistology+5

    Histopathology model that predicts single-cell type composition and reconstructs spatial gene expression from H&E slides, with no molecular assay.

    PathologySpatial omics
    16Openness
  • scLDM.CD4

    9198
    Chan Zuckerberg InitiativeNovember 4, 2025autoencodercell_biologydiffusion+7

    Single-cell latent diffusion model fine-tuned on 14.5 million CD4+ T cells to simulate transcriptomic effects of single-gene perturbations.

    Single-cell
    75Openness
  • Chan Zuckerberg Initiative +1 otherNovember 2, 2025dnafoundation_modelgene_expression+4

    Hierarchical transformer with 1.2 billion parameters that predicts personalized gene expression from diploid genomes for variant effect prediction.

    DNA & Gene
    68Openness
  • Albert Einstein College of MedicineOctober 30, 2025antibodyantibody_designembeddings+5

    Structure-based conformational B-cell epitope predictor that scores local antigen surface patches with ESM-2 embeddings and an ensemble MLP.

    Protein
    12Openness
  • Northwestern Polytechnical University +3 othersOctober 29, 2025diffusionenzyme_designenzymes+5

    Enzyme backbone design model that adds substrate and catalytic-site control to a pretrained SE(3) flow-matching generator via a lightweight adapter.

    Protein
    86Openness
  • Verily Life SciencesOctober 24, 2025cross_attentiondisease_risk_predictionelectronic_health_records+7

    Multimodal EHR foundation model that fuses polygenic risk scores into a GPT-2-style backbone by cross-attention for zero-shot disease risk prediction.

    Language modelDNA & Gene
    8Openness
  • ProSiteHunter

    Zhejiang University of TechnologyOctober 22, 2025antibodybinding_site_predictionmulti_task+3

    Sequence-based binding site predictor spanning protein-DNA, protein-RNA, protein-protein, and antibody-antigen interfaces via a fine-tuned ProtT5.

    Protein
    23Openness
  • NyxBind

    12
    Hong Kong University of Science and TechnologyOctober 21, 2025bertbinding_site_predictioncontrastive_learning+5

    Transcription factor binding site prediction model that refines a DNABERT-2 backbone with contrastive learning across diverse TFBS types.

    DNA & Gene
    40Openness
  • PepTron

    1311
    Peptone Ltd.October 18, 2025conformational_ensemble_generationdiffusionflow_matching+4

    Flow-matching model that predicts protein conformational ensembles across the order-disorder continuum, from folded domains to disordered chains.

    Protein
    91Openness
  • peleke-1

    813
    Silico Biosciences +1 otherOctober 16, 2025antibodylanguage_modelprotein_design+2

    Suite of large language models fine-tuned with LoRA to generate antigen-targeted antibody Fv sequences from an antigen and its epitope.

    Protein
    74Openness