Academic

University of Pennsylvania

An Ivy League research university in Philadelphia that prizes integration across its schools, linking medicine, engineering, and the liberal arts.

Location: Philadelphia, PA
Website
7 models(2 RNA, 2 Single-cell, 1 DNA & Gene, 1 Protein, 1 Small molecule, 1 Spatial omics, 1 Language model, 1 Imaging, 1 Pathology)

Models (7)

mRNAutilus

Atom Bioworks / University of Pennsylvania / GenScript / Duke-NUS Medical School

Released May 31, 2026

1

Masked discrete-diffusion model over millions of full-length mRNAs, steered by Monte Carlo tree search for joint codon optimization and UTR design.

RNA

Chreode

University of North Carolina at Chapel Hill / University of Texas at Austin / University of Pennsylvania

Released May 27, 2026

Cell world model pretrained on a 2.4M-cell mouse embryonic atlas, predicting one-step transcriptional state transitions and perturbation response.

Single-cell

Popformer

University of Pennsylvania

Released March 6, 2026

Self-supervised transformer for population genetics, pretrained on 1000 Genomes data, that detects positive selection via haplotype-wise attention.

DNA & Gene

PeptiVerse

University of Pennsylvania / Duke-NUS Medical School

Released January 3, 2026

5

Peptide developability predictor scoring solubility, permeability, toxicity, and binding from amino-acid sequences or chemically modified SMILES.

ProteinSmall molecule

Nephrobase Cell+

University of Pennsylvania

Released October 1, 2025

4

Kidney-specialized single-cell foundation model trained across four mammalian species for zero-shot cell-type annotation and batch integration.

Single-cellSpatial omics

TrASPr

University of Pennsylvania

Released January 20, 2025

13

Multi-transformer model that predicts tissue-specific alternative splicing outcomes and generalizes zero-shot to unseen cellular conditions.

RNA

BiomedGPT

Lehigh University / University of Georgia / Stanford University / Massachusetts General Hospital / University of Pennsylvania / University of Central Florida / UC Santa Cruz / UTHealth Houston / Mayo Clinic / Samsung Research America

Released August 7, 2024

3981706

Open-source, lightweight generalist vision-language foundation model for diverse biomedical imaging and text tasks.

Language modelImagingPathology