All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 1–24 of 85 filtered models
CREP
———Fine-tuned Enformer derivative that predicts discrete, interpretable cis-regulatory element class annotations (enhancer, promoter, insulator) directly from DNA sequence across human cell types.
DNA & Gene8OpennessCellpin
———A VAE trained on scRNA-seq reference data and applied frozen at inference to impute unmeasured genes and denoise spatial transcriptomics profiles.
Spatial omicsSingle-cell22OpennessBrainGFM
173—A graph foundation model for fMRI brain networks, pretrained across 27 datasets with graph and language prompts for zero/few-shot generalization to unseen disorders.
Biosignals16OpennessCryoProt
———Protein pretraining framework that learns representations directly from cryo-EM density maps, transferring to flexibility, active-site, binding-affinity, and stability tasks.
ImagingProtein11OpennessDanioDecima
———A zebrafish DNA sequence-to-function model predicting cell-type-specific single-cell expression across 85 cell-type x developmental-timepoint combinations during embryogenesis.
DNA & GeneSingle-cell22OpennessFlowTransOP
———A constrained deep flow-matching framework for distributional translation of omics signatures across biological domains, such as mouse-to-human transcriptomics, without paired samples.
Single-cell87Openness- Hong Kong University of Science and Technology +9 othersMay 25, 2026clinical_decision_supportfoundation_modellung_tissue+7
A subspecialty lung-pathology foundation model, fine-tuned from Virchow2 and prospectively validated across 32 clinical tasks spanning the lung diagnostic workflow.
Pathology5Openness ProtmRNA
2——A cross-modal transfer-learning model that adapts the ESM-2 650M protein language model to mRNA analysis by swapping amino-acid tokens for codon tokens, applied to mRNA benchmarks without re-training.
RNA11OpennessDamageFormer
1——Multimodal deep-learning framework that detects and localizes DNA lesions directly from native nanopore sequencing, built on the damage-aware LesionBERT foundation model.
DNA & Gene45OpennessA domain-specific foundation model for zero-shot plant root image segmentation, built on a MobileSAM backbone and trained across nine diverse root datasets.
Imaging74OpennessSpaRank
———A transferable spatial-transcriptomics deconvolution model whose rank-based spot encoding lets one pretrained model generalize across tissues, disease states, and platforms without retraining.
Spatial omics8OpennessConvergeCELL
——59A virtual cell foundation model pretrained on 23M+ cells from 5,000 patient samples for drug target and biomarker discovery.
Single-cell67Opennesssm_protgpt2
——1Three fixed ProtGPT2 fine-tunes specialized for metalloprotein generation, trained on ProteinMPNN-derived synthetic sequences.
Protein38OpennessCoMole
———A motif-aware graph diffusion transformer for controllable molecular generation that transfers to unseen properties by learning only lightweight task embeddings with the generator frozen.
Small molecule23OpennessHyperMap
———Meta-learning framework that transfers perturbation responses across cell lines, donors, and drugs from a few seed perturbations, using one-eighth the parameters of typical single-cell foundation models.
Single-cell11OpennessAF2Dock
141—A generative protein-protein docking model that adapts AlphaFold-Multimer via flow matching, replacing the template module with a docking module.
Protein77OpennessDeep-Plant
1——A supervised, chromatin-informed foundation model that predicts regulatory activity directly from plant genomic sequence in Arabidopsis and rice.
DNA & Gene87Opennessmuat
8——A portable transformer that classifies tumour types and learns representations from somatic variants, with auto-downloading WGS and WES checkpoints.
DNA & Gene65OpennessEEG foundation model pretrained by spectrogram reconstruction that improves online directional motor-imagery brain-computer interface control.
Biosignals18OpennessZeroFold
———University of Cambridge +1 otherMarch 24, 2026binding_affinity_predictioncross_attentiondrug_discovery+3A transformer that predicts protein-RNA binding affinity from Boltz-2 pre-structural embeddings via cross-modal attention, without requiring predicted structures.
RNAProtein23OpennessCLIPepPI
1——Hebrew University of JerusalemMarch 20, 2026contrastive_learningpeptide_binding_predictionprotein_protein_interaction+5Dual-encoder contrastive model that embeds protein domains and peptides into a shared space to predict domain-peptide binding specificity at proteome scale.
Protein50OpennessHERCULES
———Protein language model that predicts RNA-binding domains, global RNA-binding propensity, and mutation effects at single-residue resolution from sequence.
Protein44OpennessESMRank
———A sequence-based learning-to-rank variant effect predictor that aligns and aggregates ~1,100 overlapping deep mutational scanning assays into an assay-agnostic measure of mutational tolerance.
Protein10OpennessresLens
—1—George Washington UniversityFebruary 16, 2026antibiotic_resistance_gene_detectiongenomicslanguage_model+4A family of genomic language models fine-tuned from a pretrained DNA language model to detect and classify antibiotic resistance genes beyond reference-database limits.
DNA & Gene11Openness