All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 25–48 of 125 filtered models
SpeciefAI
———Transformer that generates multi-species antibody and nanobody framework regions at the mRNA level, conditioned on input CDRs, across six species.
ProteinRNA46OpennessPaired-sequence protein language model that jointly encodes two interacting chains to predict interactions, binding affinity, and interface contacts.
Protein27OpennessHitAnno
———Hierarchical language model for atlas-level cell-type annotation of scATAC-seq data that annotates new query datasets without retraining.
Single-cell14OpennessCALM-1.0
—3—Contrastive antibody language model predicting antibody-antigen binding specificity from sequence with a dual-encoder, cross-attentive architecture.
Protein10OpennessOncoBERT
———BERT-style language model for somatic mutations, pretrained on cancer sequencing from 210,000+ patients for tumor subtyping and therapy response.
DNA & Gene7OpennessresLens
—3—Genomic language models fine-tuned to detect and classify antibiotic resistance genes, catching divergent ARGs that reference alignment misses.
DNA & Gene11OpennessAntigenLM
———Structure-aware generative DNA language model pretrained on influenza genomes that forecasts future antigenic variants across regions and subtypes.
DNA & Gene5OpennessARSENAL
16——Masked DNA language model for regulatory genomics with a motif-discovery regularizer for zero-shot TF motif recovery and variant effect prediction.
DNA & Gene29OpennessBioBridge
—2—Connects a frozen protein language model to a general LLM via a cross-modal projector, adding protein reasoning without catastrophic forgetting.
Language modelProtein13OpennessNUWA
———mRNA language foundation model trained on ~115M protein-coding sequences across the tree of life, unifying mRNA perception and generation.
RNADNA & Gene16OpennessProust
9——Causal 309M-parameter protein language model that scores variant fitness zero-shot and generates sequences, reaching 0.390 Spearman on ProteinGym.
Protein9OpennessProtProfileMD
363—LoRA adapter on ProstT5 predicting per-residue distributions over Foldseek 3Di tokens, capturing conformational flexibility from MD trajectories.
Protein93OpennessSingle-cell RNA-seq language model that treats cells as gene-expression tokens, synthesizing whole transcriptomes from tissue and disease metadata.
Single-cellSpatial omics2OpennessCMAP
———Antibody developability predictor pairing text and protein language models, using in-context learning to fit new assays without retraining.
ProteinLanguage model4OpennessDNAChunker
—1—Masked DNA language model with a learnable, adaptive tokenizer that produces context-dependent, variable-length segments instead of fixed k-mers.
DNA & Gene23OpennessBiomeGPT
—1—Massachusetts General HospitalJanuary 5, 2026biomarker_discoverydisease_classificationfoundation_model+6Gut microbiome foundation model pretrained on human shotgun metagenomes, learning species-level taxonomic representations for disease prediction.
DNA & GeneLanguage model8OpennessGEMGen
—2—Generative language model for phenotype-driven drug discovery, proposing small-molecule structures from up- and down-regulated gene signatures.
Small moleculeSingle-cell9OpennessHELM-BERT
14—471Peptide language model trained on HELM notation, a DeBERTa encoder for property prediction on macrocyclic and non-canonical medium-sized peptides.
Small molecule80OpennessmRNA-GPT
41—GPT-style generative language model for mRNA coding sequences, pretrained across bacteria, eukaryotes, and archaea for de novo CDS design.
RNA39OpennessProFam
582—Protein-family language model trained on unaligned homolog sets for zero-shot variant fitness prediction and design. ProFam-1 holds 251M parameters.
Protein86OpennessHD-Prot
74—Multimodal protein language model that adds a continuous-token diffusion head to a discrete pLM, modeling structure without vector quantization.
Protein14Opennessvir2vec
31388Pan-viral genomic language model producing fixed genome-level embeddings of viral DNA and RNA, reused across classification tasks without retraining.
DNA & Gene53OpennessscMOBA
———Chinese Academy of Sciences +1 otherDecember 2, 2025cell_biologycell_type_annotationdata_integration+5Conversational single-cell and spatial multi-omics brain foundation model, with zero-shot cell annotation and disease prediction across species.
Single-cellLanguage model5OpennessCellHermes
30276Single-cell foundation model adapting LLaMA-3.1-8B with LoRA, recasting transcriptomes and protein interaction networks as natural-language Q&A pairs.
Single-cellRNA55Openness