National University of Singapore

Atomic-level refinement of RNA 3D structures, using geometric attention networks to guide physics-based Monte Carlo sampling and L-BFGS optimization.

370M-parameter ligand-conditioned discrete diffusion model that co-designs protein sequence and structure under explicit small-molecule constraints.

Paired-sequence protein language model that jointly encodes two interacting chains to predict interactions, binding affinity, and interface contacts.

Enzyme backbone design model that adds substrate and catalytic-site control to a pretrained SE(3) flow-matching generator via a lightweight adapter.

Multimodal LLM unifying 12-lead ECG time series, ECG images, and text for grounded, clinician-aligned electrocardiogram interpretation.

Medical vision-language model that unifies image comprehension and generation in one autoregressive transformer via heterogeneous LoRA adapters.

Brain-dynamics foundation model for resting-state fMRI, adapting the Joint-Embedding Predictive Architecture with brain gradient positioning.

SAM2-based foundation model that segments 2D and 3D medical images by treating volumes and image sets as video object tracking.

Ophthalmic imaging foundation model pretrained on 2.78M images across 11 modalities for diagnosis, prognosis, and visual question answering.

Lightweight mixture-of-experts medical vision-language model routing visual question answering and image classification to domain-specific experts.

Tokenized graph transformer that embeds longitudinal brain functional connectomes from fMRI for interpretable neurodegenerative disease diagnosis.

Self-supervised vision foundation model pretrained on 1.3M medical images via second-order graph matching, for segmentation and classification.