All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 1–24 of 26 filtered models
LEAF-1
———Genomics foundation model that represents individual DNA fragments in a learned semantic space for cell-free DNA cancer detection and cell typing.
DNA & GeneSingle-cell4OpennessOneGenome-Rice
25—15Genomic foundation model for rice, pretrained on 422 Oryza genomes with a 1 Mbp context window and a 1.25B-parameter mixture-of-experts transformer.
DNA & Gene90OpennessDeep-Plant
1——Chromatin-informed foundation model predicting regulatory activity and chromatin state directly from plant genomic sequence in Arabidopsis and rice.
DNA & Gene87OpennessARCH3D
———Foundation model for 3D genome architecture, using masked locus modeling over genome-wide contact profiles to capture chromosome-scale organization.
DNA & Gene19OpennessChIANet
———Multimodal deep learning model that predicts protein-mediated chromatin contact maps and loops de novo from protein-binding profiles and sequence.
DNA & Gene10OpennessCLM-X
———Hangzhou Institute of Medicine, CASFebruary 18, 2026batch_correctioncell_biologycell_type_annotation+6Multimodal single-cell foundation model whose multiway Transformer jointly models scRNA-seq and scATAC-seq from RNA-only, ATAC-only, or paired inputs.
Single-cell4OpennessARSENAL
16——Masked DNA language model for regulatory genomics with a motif-discovery regularizer for zero-shot TF motif recovery and variant effect prediction.
DNA & Gene29OpennessGenoME
—1—Mixture-of-Experts generative model turning DNA sequence plus cell-type ATAC-seq into unified epigenomic, transcriptomic, and 3D chromatin profiles.
DNA & GeneSingle-cell8OpennessPuget
———Gene expression prediction model combining DNA sequence with Hi-C contact maps to capture 3D chromatin looping behind cell-type-specific expression.
DNA & Gene8OpennessEvo2HiC
102—University of WashingtonNovember 19, 2025chromatinchromatin_contact_predictionepigenomic_profiling+9Multimodal foundation model that distills Evo 2 into a compact encoder guided by Hi-C data, predicting cell-type-specific 3D genome architecture.
DNA & GeneSpatial omics57OpennessAtacformer
28297Transformer foundation model for single-cell ATAC-seq that embeds both cells and cis-regulatory elements for annotation and batch correction.
Single-cellDNA & Gene32OpennessScooby
6912463Technical University of Munich +4 othersOctober 1, 2025chromatinchromatin_accessibility_predictionconvolutional_neural_network+5Predicts single-cell scRNA-seq coverage and scATAC-seq insertion profiles from DNA sequence, adapting the Borzoi trunk with a cell-specific decoder.
Single-cell70OpennessChromnitron
261—Multimodal foundation model predicting genome-wide binding of chromatin-associated proteins from protein sequence, DNA sequence, and chromatin state.
DNA & GeneProtein25OpennessGREmLN
38——Single-cell transcriptomics foundation model that encodes gene regulatory network structure into self-attention through graph signal processing.
Single-cell80OpennessAlphaGenome
2K154—DNA foundation model that predicts thousands of functional genomic tracks, from expression and splicing to chromatin, at single base-pair resolution.
DNA & Gene49OpennessLOL-EVE
238Conditional autoregressive genomic language model trained on 13.6M mammalian promoters, scoring promoter variants, including indels, zero-shot.
DNA & Gene89OpennessChromatin-state language model pretrained on ROADMAP annotations from 127 human cell types to find chromatin-state motifs and predict gene expression.
DNA & Gene86OpennessPuffin
10655—Interpretable model of human transcription initiation that decomposes promoter activity into a minimal set of sequence rules at base-pair resolution.
DNA & Gene23OpennessEpiGePT
3311—Transformer model predicting context-specific epigenomic signals across cell types using DNA sequence and transcription factor activity profiles.
DNA & Gene65OpennessTransferChrome
—20—Gene expression prediction from histone modifications, combining self-attention with dense convolutions and transfer learning across cell types.
DNA & Gene22OpennessChromoformer
3944—Transformer predicting gene expression from histone modifications, using promoter-enhancer Hi-C interactions to capture distal regulatory effects.
DNA & Gene71OpennessGeneBERT
—27—Multi-modal self-supervised transformer for regulatory genomics, pre-trained on DNA sequence together with transcription factor binding matrices.
DNA & Gene18OpennessBasenji2
473225—Cross-species convolutional network trained jointly on human and mouse genomes to predict regulatory sequence activity and noncoding variant effects.
DNA & Gene79OpennessBasenji
473515—Dilated convolutional network that predicts cell-type-specific epigenetic and transcriptional profiles from DNA sequence across mammalian genomes.
DNA & Gene73Openness