UT Southwestern Medical Center

Structure-conditioned protein sequence design, pairing a three-track architecture with discrete flow matching for fast, few-step inverse folding.

All-atom structure prediction for arbitrary biomolecular complexes of proteins, nucleic acids, and ligands, with code and weights under a BSD license.

Digital cytology foundation model, a ViT-Base pretrained with iBOT self-supervision on 1.4 million patches from breast, cervical, and thyroid slides.

Interpretable model of human transcription initiation that decomposes promoter activity into a minimal set of sequence rules at base-pair resolution.

Protein structure prediction for monomers and complexes in one three-track network, scaling past 1000 residues without triangle attention.

In silico saturation mutagenesis in a single forward pass, scoring every substitution in a 2 kb window across 2,002 chromatin profiles.

Chromatin-level variant effect prediction from DNA sequence, projecting 21,907 predicted regulatory profiles onto 40 interpretable sequence classes.

Predicts 3D genome architecture directly from DNA sequence across nine scales, from 4-kb contacts up to a 256-Mb whole-chromosome window.

Protein structure and complex prediction from sequence, in a three-track network that reasons over alignments, distances, and 3D coordinates at once.