All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 97–120 of 158 filtered models
Multimodal conversational LLM for metabolite analysis, fusing a molecular-graph GNN and molecular-image CNN with a Vicuna-13B language backbone.
MetabolomicsSmall molecule48OpennessTEMPO
—5—Chinese University of Hong Kong, Shenzhen +1 otherNovember 7, 2025autoregressiveconformational_ensemble_generationgenerative+4Protein dynamics model that samples conformational ensembles autoregressively at slow and fast timescales, generalizing zero-shot to unseen proteins.
Protein25OpennessH3BERTa
1—201Antibody language model pretrained only on CDR-H3 loops, giving embeddings for immune repertoire analysis and antibody sequence classification.
ProteinLanguage model83OpennessPaired heavy/light antibody language model fine-tuning ESM-2 and ESM-C with CDR-preferential masking for zero-shot binding affinity embeddings.
Protein8Openness- Verily Life SciencesOctober 24, 2025cross_attentiondisease_risk_predictionelectronic_health_records+7
Multimodal EHR foundation model that fuses polygenic risk scores into a GPT-2-style backbone by cross-attention for zero-shot disease risk prediction.
Language modelDNA & Gene8Openness EvoIF
———Zhejiang University +1 otherOctober 8, 2025graph_neural_networkprotein_evolutionprotein_fitness_prediction+4Compact protein fitness predictor that fuses within-family evolutionary profiles with inverse-folding logits for zero-shot variant effect prediction.
Protein26OpennessRareFoldGPCR
142—GPCR structure prediction and peptide design model that generates linear and cyclic peptide agonists carrying noncanonical amino acids, zero-shot.
Protein58OpennessFLOWR.root
1383—SE(3)-equivariant flow-matching model for pocket-aware 3D ligand generation, predicting binding affinity and confidence in the same network.
Small moleculeProtein87OpennessKidney-specialized single-cell foundation model trained across four mammalian species for zero-shot cell-type annotation and batch integration.
Single-cellSpatial omics22OpennessBioVERSE
—2—Multimodal biomedical framework aligning frozen single-cell and protein model encoders to an LLM's embedding space for zero-shot reasoning.
Language modelSingle-cellProtein23OpennessscYeast
51—Single-cell foundation model for yeast that injects regulatory network priors into transformer attention for zero-shot and fine-tuned analysis.
Single-cell68OpennessChromnitron
261—Multimodal foundation model predicting genome-wide binding of chromatin-associated proteins from protein sequence, DNA sequence, and chromatin state.
DNA & GeneProtein25OpennessHistology vision transformer with 80M parameters that predicts spatial gene expression from H&E tissue images and transfers to tumor detection.
PathologySpatial omics59OpennessCLASP
44—Tri-modal contrastive model aligning protein structure, sequence, and text in a shared space for zero-shot cross-modal retrieval and classification.
Protein42OpennessstructRFM
36329RNA foundation model pretrained jointly on sequences and secondary structures for structure prediction, homology and splice site classification.
RNA92OpennessProteomeLM
363237EPFLAugust 1, 2025foundation_modelgene_essentiality_predictionprotein_protein_interaction_prediction+4Proteome-scale protein language model whose representations enable zero-shot protein-protein interaction and gene essentiality prediction.
Protein64OpennessSurface-EMG wristband models that decode hand gestures, handwriting, and wrist movement, generalizing across users without per-person calibration.
Biosignals13OpennessChai-2
—58—Multimodal all-atom generative model for zero-shot de novo antibody and protein-binder design, validated by wet-lab hit rates from small batches.
Protein7OpennessSensorLM
—58—Google Research +2 othersJune 10, 2025activity_recognitioncontrastive_learningcross_modal_retrieval+6Sensor-language foundation models aligning wearable biosignals with text for zero-shot activity recognition, retrieval, and sensor captioning.
BiosignalsLanguage model41OpennessBioCLIP 2
774348.7KVision foundation model for the tree of life, trained on 214 million organism images across 952,000 taxa for zero-shot species classification.
Imaging93OpennessTranscriptFormer
15736—Generative single-cell foundation model trained on 112 million cells from 12 species, autoregressively modeling gene identities and expression counts.
Single-cell67OpennessSwin-BOB
504—3D MRI organ segmentation foundation model built on Swin-UNETR and trained on the UKBOB whole-body dataset covering 72 organs and skeletal structures.
Imaging64OpennessscDNAm-GPT
202—Guangzhou Medical University +1 otherFebruary 23, 2025cell_type_annotationcross_attentiondna_methylation+5Single-cell DNA methylation foundation model capturing genome-wide CpG dependencies in whole-genome bisulfite sequencing across tissues and species.
Single-cellDNA & Gene78OpennessFetalCLIP
7022—Mohamed bin Zayed University of Artificial Intelligence +1 otherFebruary 20, 2025classificationcontrastive_learningfoundation_model+7Vision-language foundation model for fetal ultrasound, pretrained on 210,035 image-text pairs for plane classification, biometry, and segmentation.
Imaging13Openness