Pfizer

B-cell epitope prediction from antigen sequence alone. Fine-tunes ESM-2 with LoRA instead of freezing it, and scores antigens up to 1,724 residues.

Open-source Apache-2.0 reproduction of AlphaFold3 that predicts all-atom structures of proteins, RNA, DNA, small molecules, and their complexes.

SE(3)-equivariant flow-matching model for pocket-aware 3D ligand generation, predicting binding affinity and confidence in the same network.

Cell Painting generative model encoding lab, batch, and well position as causal variables, predicting mechanism and target for unseen compounds.