Guangzhou Medical University

Virtual-cell model that compresses a transcriptome into eight discrete tokens in a reasoning LLM's vocabulary, predicting module-level drug response.

Diffusion super-resolution for H&E whole-slide images, steering denoising with SAM-derived structural anchors and adapted DINOv3 semantic control.

Frozen-section pathology foundation model for intraoperative diagnosis, LoRA-adapted from Virchow2 and validated in a prospective surgical study.

Generative antibody and nanobody design model that co-designs CDR sequences and antigen-bound structures for de novo design and affinity maturation.

Multimodal single-cell foundation model pretrained on 4M+ co-assayed cells, predicting 382 surface proteins from transcriptomes alone, zero-shot.

Single-cell DNA methylation foundation model capturing genome-wide CpG dependencies in whole-genome bisulfite sequencing across tissues and species.

Multiomic foundation model for zero-shot in silico perturbation, predicting gene regulation and cell fate transitions from DNA and ATAC signal.