All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 1–24 of 158 filtered models
LEAF-1
———Genomics foundation model that represents individual DNA fragments in a learned semantic space for cell-free DNA cancer detection and cell typing.
DNA & GeneSingle-cell4OpennessTRIOPS
———T-cell receptor-MHC restriction prediction from amino acid sequence, mapping TCRs to their restricting HLA allele at 0.97 held-out AUC.
Protein22OpennessGAZE
———Physics-informed graph neural network predicting metabolite concentrations from gene expression, generalizing zero-shot to unseen metabolites.
MetabolomicsSmall moleculeDNA & Gene19OpennessHistopathology-to-molecular alignment model that queries H&E slides with gene-set signatures to predict pathway activity without sequencing.
PathologyRNA16OpennessPlantGeneAnn
12—126Plant genome foundation model for ab initio gene structure annotation, predicting genes, coding sequences, and exons at single-nucleotide resolution.
DNA & Gene66OpennessNavigo
12——Chinese University of Hong Kong +1 otherJune 24, 2026cell_fate_engineeringflow_matchinggene_regulatory_network_inference+6Generative framework that learns a developmental vector field from scRNA-seq snapshots, coupling flow matching with molecular RNA kinetics.
Single-cellRNA44OpennessJEDEL
———Zero-shot generative framework that turns 3D pharmacophores into synthesis-ready DNA-encoded libraries of purchasable building blocks.
Small molecule23OpennessGENATATOR
——23Ab initio gene annotation model that predicts gene boundaries and exon-intron structure from raw DNA, generalizing zero-shot to unseen species.
DNA & GeneRNA22OpennessOmnii
———Genomic language model from Radical Numerics with a 2 Mbp context window, built for zero-shot variant effect prediction and sequence design.
DNA & Gene5OpennessTifBERT
2——Bulk RNA-seq foundation model learning normalization-robust transcriptome representations via TF-IDF gene ordering and masked gene modeling.
RNA17OpennessMethylSeqNet
———University of California, Berkeley +1 otherJune 7, 2026chromatin_accessibility_predictiondna_methylationepigenetics+6Gene regulation model that conditions a pretrained DNA sequence embedding on CpG methylation to capture cell-type and allele-specific regulation.
DNA & Gene18OpennessVelocityFM
———University of Colombo School of Computing +1 otherJune 7, 2026conformational_samplingflow_matchinggenerative+4Generative protein-dynamics model that predicts short molecular dynamics trajectories with rectified flow matching over residue frames and torsions.
Protein21OpennessCellpin
———Variational autoencoder trained on scRNA-seq and applied frozen to impute unmeasured genes and denoise spatial transcriptomics profiles.
Spatial omicsSingle-cell22Opennesstf-SFM
—2—Transcription factor-DNA binding specificity prediction from sequence, with a physics-derived dual-encoder trained by symmetric contrastive learning.
DNA & Gene18Opennessdrug-SFM
—1—Specificity foundation model predicting small-molecule drug-target binding from sequence, scored as cross-modal retrieval without docking or assays.
Small molecule16OpennessReCLIP
———University of Chicago +2 othersJune 4, 2026multi_taskprotein_protein_interaction_predictionproteomics+4Transformer that predicts protein-protein interactions at residue resolution, spanning mutations, PTMs, peptide-MHC binding, and disease variants.
Protein22OpennesscrisprSFM
—2—CRISPR off-target prediction model that scores gRNA-DNA specificity from sequence, framing guide-target recognition as cross-modal retrieval.
DNA & Gene19Opennessenzyme-SFM
—2—Enzyme-substrate specificity model that scores catalytic pairs from sequence with a physics-derived dual-encoder and a contrastive objective.
Protein23OpennessmhcSFM
—2—Peptide-MHC binding specificity model that frames presentation as cross-modal retrieval, aligning peptide and MHC encoders by contrastive learning.
Protein23Opennessmir-SFM
—2—Foundation model that predicts microRNA-mRNA target specificity from sequence, using a dual-encoder trained with a symmetric contrastive objective.
RNA25OpennessBrainGFM
173—Graph foundation model for fMRI brain networks, pretrained across 27 datasets with graph and language prompts for zero-shot disorder classification.
Biosignals16OpennessVermeer
3——Generative microscopy foundation model that synthesizes in-silico fluorescence images of protein subcellular localization from amino-acid sequence.
ImagingProtein17OpennessAMix-2
———Protein-text foundation model placing amino acid sequences and natural language in one token space for protein understanding and de novo design.
ProteinLanguage model10OpennessSciCore-Omics
10—69Tri-modal foundation model unifying histology images, spatial transcriptomics, and language for zero-shot pathology and spatial biology reasoning.
PathologySpatial omics65Openness