All Competitors

Every biological foundation model, evaluated and ranked by the bio.rodeo team

Showing 7396 of 158 filtered models

  • OKR-CELL

    BGI ResearchJanuary 9, 2026batch_effect_correctioncell_biologycell_clustering+7

    Cross-modal single-cell foundation model that aligns gene-expression profiles with LLM-enriched cell descriptions in a shared embedding space.

    Single-cellLanguage model
    23Openness
  • STACK

    14211
    Arc Institute +1 otherJanuary 9, 2026foundation_modelin_context_learningperturbation_prediction+4

    Single-cell foundation model using tabular attention over context cells to predict responses to arbitrary perturbations without fine-tuning.

    Single-cell
    33Openness
  • NetMedGPT

    2
    University of Hamburg +1 otherJanuary 4, 2026drug_discoverydrug_repurposingfoundation_model+6

    Transformer foundation model pretrained on a biomedical knowledge graph for zero-shot drug repurposing, target, and adverse-effect prediction.

    Language modelSmall molecule
    24Openness
  • GEMGen

    2
    Westlake University +1 otherJanuary 3, 2026de_novo_designdrug_discoverygenerative+5

    Generative language model for phenotype-driven drug discovery, proposing small-molecule structures from up- and down-regulated gene signatures.

    Small moleculeSingle-cell
    9Openness
  • OmniCell

    1
    BGI ResearchDecember 29, 2025cell_type_annotationfoundation_modelgene_expression+6

    Transcriptomic foundation model pretrained on 67M single-cell and spatial profiles, modeling gene expression and inter-cellular dependencies.

    Single-cellSpatial omics
    9Openness
  • Baylor College of MedicineDecember 25, 2025cancerfoundation_modelligand_target_inference+7

    Spatially aware transcriptomic foundation models for cancer, pairing 50um-Local and 250um-Extended views of spot-resolution spatial transcriptomes.

    Spatial omics
    12Openness
  • MAGNET

    Huazhong University of Science and TechnologyDecember 25, 2025denoisingfluorescence_microscopyfoundation_model+7

    Microscopy image restoration foundation model unifying 8 tasks across 5 modalities and 2D/3D data, with zero-shot inference on unseen systems.

    Imaging
    7Openness
  • FOCUS

    University of CambridgeDecember 23, 2025diffusionfoundation_modelgene_expression_imputation+8

    Generative foundation model that imputes genes and denoises spatial transcriptomics, conditioned on H&E histology, scRNA-seq, and spatial priors.

    Spatial omicsPathologySingle-cell
    4Openness
  • ProFam

    582
    University College London +1 otherDecember 21, 2025de_novo_designgenerativelanguage_model+5

    Protein-family language model trained on unaligned homolog sets for zero-shot variant fitness prediction and design. ProFam-1 holds 251M parameters.

    Protein
    86Openness
  • Helix

    3
    Shape TherapeuticsDecember 20, 2025a_to_i_editingguide_rna_designknowledge_distillation+4

    Structure-aware transformer that makes zero-shot, per-adenosine predictions of ADAR-mediated A-to-I RNA editing to guide therapeutic guide-RNA design.

    RNA
    4Openness
  • OmniNovo

    Fudan University +8 othersDecember 13, 2025de_novo_peptide_sequencingfoundation_modelmass_spectrometry+4

    De novo peptide sequencing transformer that reads modified and unmodified peptides directly from tandem mass spectra without a reference database.

    Protein
    14Openness
  • ISTS

    New York UniversityDecember 2, 2025autoencoderbertcancer_classification+9

    Pan-cancer multi-omic foundation model encoding CpG-island DNA methylation and RNA-seq for zero-shot cancer classification and mutation prediction.

    Single-cellDNA & Gene
    20Openness
  • scMOBA

    Chinese Academy of Sciences +1 otherDecember 2, 2025cell_biologycell_type_annotationdata_integration+5

    Conversational single-cell and spatial multi-omics brain foundation model, with zero-shot cell annotation and disease prediction across species.

    Single-cellLanguage model
    5Openness
  • TEA

    2443.7K
    Biozentrum +2 othersNovember 27, 2025contrastive_learninghomology_detectionproteomics+4

    Protein sequence encoder that maps ESM2 embeddings to a learned 20-letter alphabet for structure-quality remote homology detection at MMseqs2 speed.

    Protein
    86Openness
  • PULSAR

    364166
    Stanford UniversityNovember 26, 2025biomarker_predictiondisease_classificationfoundation_model+6

    Hierarchical single-cell foundation model that turns scRNA-seq profiles into zero-shot donor-level embeddings for disease and biomarker prediction.

    Single-cellProtein
    58Openness
  • RNA-X

    41
    Bilkent UniversityNovember 26, 2025de_novo_designfoundation_modelmasked_language_model+5

    RNA interaction foundation model for conditional, zero-shot design of RNA sequences that bind protein, DNA, or RNA targets without retraining.

    RNAProtein
    6Openness
  • Melody

    Shandong University +2 othersNovember 23, 2025cnndna_methylationepigenomics+5

    Deep learning framework that predicts DNA methylation from genomic sequence across 39 human tissues, with an scRNA-seq variant for unseen cell types.

    DNA & Gene
    8Openness
  • MethylAI

    7
    Guangzhou National LaboratoryNovember 20, 2025cnndnaepigenetics+6

    Cross-species-pretrained CNN that predicts single-CpG DNA methylation from genomic sequence and interprets the cis-regulatory motifs that govern it.

    DNA & Gene
    64Openness
  • Evo2HiC

    102
    University of WashingtonNovember 19, 2025chromatinchromatin_contact_predictionepigenomic_profiling+9

    Multimodal foundation model that distills Evo 2 into a compact encoder guided by Hi-C data, predicting cell-type-specific 3D genome architecture.

    DNA & GeneSpatial omics
    57Openness
  • SHEST

    1
    Samsung Advanced Institute for Health Sciences and Technology +2 othersNovember 19, 2025cell_type_annotationgene_expressionhistology+5

    Histopathology model that predicts single-cell type composition and reconstructs spatial gene expression from H&E slides, with no molecular assay.

    PathologySpatial omics
    16Openness
  • MergeDNA

    5
    Westlake University +1 otherNovember 17, 2025foundation_modelgenomicsmulti_omics+6

    Hierarchical DNA foundation model that co-trains a dynamic token-merging tokenizer with latent Transformers to match genomic information density.

    DNA & Gene
    5Openness
  • E1

    1131115.5K
    ProfluentNovember 13, 2025contact_predictionfoundation_modelproteomics+6

    Retrieval-augmented protein encoders that fuse homologous sequences into a single-pass transformer for variant effect and contact prediction.

    Protein
    47Openness
  • CryoSiam

    201
    European Molecular Biology LaboratoryNovember 12, 2025convolutional_neural_networkcryo_etdenoising+8

    Self-supervised Siamese network for cryo-electron tomography, enabling zero-shot denoising, segmentation, and macromolecule detection in tomograms.

    Imaging
    64Openness
  • Technical University of MunichNovember 10, 2025mass_spectrometryproteomicsptm_localization+3

    Spectral prediction model for modified peptides, forecasting fragment-ion intensities and retention time with zero-shot generalization to unseen PTMs.

    Protein
    30Openness