European Molecular Biology Laboratory

Self-supervised Siamese network for cryo-electron tomography, enabling zero-shot denoising, segmentation, and macromolecule detection in tomograms.

Natural product chemistry prediction from biosynthetic gene clusters, assigning ChemOnt ontology classes from the cluster's Pfam domain composition.

Sparse all-atom denoising models for de novo protein backbone generation, producing designable structures up to 1,000 residues in seconds.

Spot detection and quantification in 5D fluorescence microscopy. Pretrained 2D and 3D U-Nets segment foci, then Gaussian fitting measures each one.

Threshold-agnostic spot detection for 2D and 3D fluorescence microscopy, locating transcripts at subpixel accuracy via stereographic flow regression.