All Competitors

Every biological foundation model, evaluated and ranked by the bio.rodeo team

Showing 4972 of 203 filtered models

  • ATOMICA

    3
    Harvard UniversityMarch 16, 2026binding_site_predictionfoundation_modelgraph_neural_network+6

    Geometric deep learning model that learns atomic-scale representations of molecular interfaces across proteins, small molecules, and nucleic acids.

    ProteinSmall moleculeRNA
    88Openness
  • Stoic

    15155
    University of BaselMarch 16, 2026graph_neural_networkrepresentation_learningsupervised+1

    Predicts protein complex stoichiometry from amino acid sequence alone, ranking copy numbers in seconds and exporting AlphaFold3-ready JSON files.

    Protein
    59Openness
  • CDS-BART

    9
    MOGAM Institute for Biomedical ResearchMarch 12, 2026bartfoundation_modelgene_expression+5

    Coding-sequence foundation model for mRNA design, pretrained as a BART denoising encoder-decoder on mRNA from nine taxonomic groups.

    RNA
    63Openness
  • PatchDNA

    2
    Relation TherapeuticsMarch 12, 2026dnafoundation_modelgenomics+4

    DNA language model that replaces fixed tokenization with conservation-guided patching, letting models up to 10x smaller match top genomic benchmarks.

    DNA & Gene
    33Openness
  • MIT +1 otherMarch 11, 2026cell_type_annotationfoundation_modelgene_expression_prediction+7

    Cell-centric microscopy foundation model that distills morphology and microenvironment views into a unified embedding for virtual spatial omics.

    Spatial omicsImagingPathology
    15Openness
  • Duke UniversityMarch 8, 2026embeddingsknowledge_distillationproteomics+3

    Post-hoc method that restores monotonic scaling to ESM-2 embeddings, yielding Matryoshka-style nested representations for variant effect prediction.

    Protein
    58Openness
  • BacPT

    1
    University of FloridaMarch 7, 2026bacterial_genomicsenzyme_annotationfoundation_model+6

    Bacterial proteome foundation model that learns contextualized gene and whole-genome representations from tens of thousands of complete genomes.

    Protein
    10Openness
  • ProtAlign

    Lawrence Livermore National LaboratoryMarch 6, 2026contrastive_learningcross_modal_retrievalembeddings+4

    Cross-modal protein encoder that aligns ESM-2 sequence embeddings with ProteinMPNN structure embeddings in a shared space for cross-modal retrieval.

    Protein
    35Openness
  • ProtNHF

    Oak Ridge National LaboratoryMarch 6, 2026de_novo_designflow_matchinggenerative+4

    Neural Hamiltonian flow for protein sequence generation with inference-time control over composition and net charge via analytical bias potentials.

    Protein
    64Openness
  • Popformer

    University of PennsylvaniaMarch 6, 2026foundation_modelgenomicspopulation_genetics+6

    Self-supervised transformer for population genetics, pretrained on 1000 Genomes data, that detects positive selection via haplotype-wise attention.

    DNA & Gene
    19Openness
  • RigidSSL

    201
    Chinese University of Hong KongMarch 2, 2026conformational_ensemble_generationflow_matchinggenerative+5

    Self-supervised SE(3) geometric pretraining for protein backbone generators, improving designability, motif scaffolding, and conformational ensembles.

    Protein
    73Openness
  • FlashPPI

    40140.8K
    Tatta BioMarch 1, 2026contrastive_learninginteraction_network_inferencemetagenomics+4

    Contrastive model built on a genomic language model that predicts physical protein-protein interactions across a microbial proteome in linear time.

    Protein
    14Openness
  • CALM-1.0

    3
    ETH ZurichFebruary 26, 2026antibodyantibody_designantigen+6

    Contrastive antibody language model predicting antibody-antigen binding specificity from sequence with a dual-encoder, cross-attentive architecture.

    Protein
    10Openness
  • ESMRank

    TIGEMFebruary 26, 2026deep_mutational_scanningproteomicsrepresentation_learning+3

    Learning-to-rank variant effect predictor that aligns overlapping deep mutational scanning assays into an assay-agnostic tolerance measure.

    Protein
    10Openness
  • ARCH3D

    University of MichiganFebruary 25, 20263d_genomechromatincontact_map_reconstruction+5

    Foundation model for 3D genome architecture, using masked locus modeling over genome-wide contact profiles to capture chromosome-scale organization.

    DNA & Gene
    19Openness
  • Vanderbilt University Medical CenterFebruary 23, 2026drug_discoveryfoundation_modelgraph_neural_network+4

    Knowledge-graph foundation model for drug repurposing, grounding a biomedical graph in cell-type-specific genetic associations to rank indications.

    Single-cellSmall molecule
    11Openness
  • EnzPlacer

    Iowa State UniversityFebruary 23, 2026contrastive_learningec_number_predictionembeddings+6

    Enzyme function prediction model that uses contrastive learning to assign the first three EC digits to enzymes with functions unseen during training.

    Protein
    59Openness
  • PLUM

    1
    Iowa State UniversityFebruary 21, 2026antimicrobial_peptidesde_novo_designgenerative+3

    Conditional variational autoencoder for antimicrobial peptide design that disentangles sequence, function, and length for independent control.

    Protein
    56Openness
  • JEPA-DNA

    178
    NVIDIAFebruary 19, 2026dnafoundation_modelgenomics+5

    Genomic foundation model training framework whose joint-embedding predictive objective learns functional representations of masked DNA, not tokens.

    DNA & Gene
    54Openness
  • BOND-PEP

    University of SydneyFebruary 18, 2026de_novo_designgenerativepeptides+3

    Retrieval-augmented framework for de novo peptide binder design that conditions generation on retrieved, structurally aligned binding evidence.

    Protein
    5Openness
  • Florida International UniversityFebruary 17, 2026cheminformaticsdebertafoundation_model+4

    SMILES molecular encoder on a DeBERTaV2 backbone, pretrained on 123M PubChem molecules with physicochemical and structural-similarity objectives.

    Small molecule
    25Openness
  • Tsinghua UniversityFebruary 14, 2026autoregressivecell_biologyde_novo_design+7

    Protein language model that encodes sequences as discrete words from a learned vocabulary for zero-shot function inference and protein design.

    Protein
    24Openness
  • DERIVE

    Guangzhou National LaboratoryFebruary 12, 2026flow_matchingfoundation_modelgenerative+5

    Multimodal generative model predicting viral antigenic change zero-shot from disentangled evolutionary, physicochemical, and structural signals.

    Protein
    16Openness
  • BioLM-Score

    Shenzhen UniversityFebruary 9, 2026binding_affinity_predictiondrug_discoverymixture_density_network+4

    Protein-ligand scoring function that conditions probabilistic geometric potentials on language model priors to rank docked poses and binding affinity.

    ProteinSmall molecule
    11Openness