All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 49–72 of 203 filtered models
ATOMICA
—3—Geometric deep learning model that learns atomic-scale representations of molecular interfaces across proteins, small molecules, and nucleic acids.
ProteinSmall moleculeRNA88OpennessStoic
15—155Predicts protein complex stoichiometry from amino acid sequence alone, ranking copy numbers in seconds and exporting AlphaFold3-ready JSON files.
Protein59OpennessCDS-BART
——9Coding-sequence foundation model for mRNA design, pretrained as a BART denoising encoder-decoder on mRNA from nine taxonomic groups.
RNA63OpennessPatchDNA
—2—DNA language model that replaces fixed tokenization with conservation-guided patching, letting models up to 10x smaller match top genomic benchmarks.
DNA & Gene33OpennessCell-centric microscopy foundation model that distills morphology and microenvironment views into a unified embedding for virtual spatial omics.
Spatial omicsImagingPathology15OpennessPost-hoc method that restores monotonic scaling to ESM-2 embeddings, yielding Matryoshka-style nested representations for variant effect prediction.
Protein58OpennessBacPT
—1—Bacterial proteome foundation model that learns contextualized gene and whole-genome representations from tens of thousands of complete genomes.
Protein10OpennessProtAlign
———Lawrence Livermore National LaboratoryMarch 6, 2026contrastive_learningcross_modal_retrievalembeddings+4Cross-modal protein encoder that aligns ESM-2 sequence embeddings with ProteinMPNN structure embeddings in a shared space for cross-modal retrieval.
Protein35OpennessProtNHF
———Neural Hamiltonian flow for protein sequence generation with inference-time control over composition and net charge via analytical bias potentials.
Protein64OpennessPopformer
———Self-supervised transformer for population genetics, pretrained on 1000 Genomes data, that detects positive selection via haplotype-wise attention.
DNA & Gene19OpennessRigidSSL
201—Chinese University of Hong KongMarch 2, 2026conformational_ensemble_generationflow_matchinggenerative+5Self-supervised SE(3) geometric pretraining for protein backbone generators, improving designability, motif scaffolding, and conformational ensembles.
Protein73OpennessCALM-1.0
—3—Contrastive antibody language model predicting antibody-antigen binding specificity from sequence with a dual-encoder, cross-attentive architecture.
Protein10OpennessARCH3D
———Foundation model for 3D genome architecture, using masked locus modeling over genome-wide contact profiles to capture chromosome-scale organization.
DNA & Gene19OpennessCellAwareGNN
—1—Vanderbilt University Medical CenterFebruary 23, 2026drug_discoveryfoundation_modelgraph_neural_network+4Knowledge-graph foundation model for drug repurposing, grounding a biomedical graph in cell-type-specific genetic associations to rank indications.
Single-cellSmall molecule11OpennessEnzPlacer
———Enzyme function prediction model that uses contrastive learning to assign the first three EC digits to enzymes with functions unseen during training.
Protein59OpennessPLUM
1——Conditional variational autoencoder for antimicrobial peptide design that disentangles sequence, function, and length for independent control.
Protein56OpennessBOND-PEP
———Retrieval-augmented framework for de novo peptide binder design that conditions generation on retrieved, structurally aligned binding evidence.
Protein5OpennessMolDeBERTa
4—5SMILES molecular encoder on a DeBERTaV2 backbone, pretrained on 123M PubChem molecules with physicochemical and structural-similarity objectives.
Small molecule25OpennessProtein language model that encodes sequences as discrete words from a learned vocabulary for zero-shot function inference and protein design.
Protein24OpennessDERIVE
———Multimodal generative model predicting viral antigenic change zero-shot from disentangled evolutionary, physicochemical, and structural signals.
Protein16OpennessBioLM-Score
———Shenzhen UniversityFebruary 9, 2026binding_affinity_predictiondrug_discoverymixture_density_network+4Protein-ligand scoring function that conditions probabilistic geometric potentials on language model priors to rank docked poses and binding affinity.
ProteinSmall molecule11Openness