All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 25–42 of 42 filtered models
Spatially aware transcriptomic foundation models for cancer, pairing 50um-Local and 250um-Extended views of spot-resolution spatial transcriptomes.
Spatial omics12OpennessFOCUS
———Generative foundation model that imputes genes and denoises spatial transcriptomics, conditioned on H&E histology, scRNA-seq, and spatial priors.
Spatial omicsPathologySingle-cell4OpennessM-Optimus
———Multimodal foundation model that embeds histology, transcriptomics, and clinical records in one space for patient stratification and target discovery.
PathologySpatial omicsSingle-cell3OpennessEXAONE Path 2.5
5272Pathology foundation model that aligns whole-slide images with genomic, epigenetic, and transcriptomic data for patient-level tumor representations.
PathologySpatial omics14OpennessEva
—4—Enable Medicine +4 othersDecember 12, 2025cell_type_annotationcross_modal_inferencefoundation_model+8Tissue imaging foundation model pretrained on matched H&E histology and spatial proteomics for cross-modal inference and zero-shot retrieval.
PathologySpatial omics4OpennessTissueNarrator
5211—Spatial transcriptomics language model that reads tissue as spatial sentences to simulate cell profiles and run in silico perturbations.
Spatial omicsSingle-cell53OpennessMIMYR
—202—Generative framework that reconstructs missing spatial transcriptomics regions by jointly predicting cell locations, cell types, and gene expression.
Spatial omicsSingle-cell16OpennessSIGMMA
—1—Helmholtz Munich +1 otherNovember 19, 2025contrastive_learningcross_modal_retrievalgene_expression_prediction+7Multi-modal contrastive model that aligns H&E histopathology with spatial transcriptomics across tissue scales to predict gene expression from images.
PathologySpatial omics20OpennessEvo2HiC
92—University of WashingtonNovember 19, 2025chromatinchromatin_contact_predictionepigenomic_profiling+9Multimodal foundation model that distills Evo 2 into a compact encoder guided by Hi-C data, predicting cell-type-specific 3D genome architecture.
DNA & GeneSpatial omics57OpennessSHEST
129—Samsung Advanced Institute for Health Sciences and Technology +2 othersNovember 19, 2025cell_type_annotationgene_expressionhistology+5Histopathology model that predicts single-cell type composition and reconstructs spatial gene expression from H&E slides, with no molecular assay.
PathologySpatial omics16OpennessMetaboFM
—3—Georgia Institute of TechnologyOctober 23, 2025classificationfoundation_modelmass_spectrometry_imaging+6Vision Transformer foundation model for spatial metabolomics, pretrained on ~4,000 curated METASPACE mass spectrometry imaging datasets.
MetabolomicsSpatial omicsImaging10OpennessKidney-specialized single-cell foundation model trained across four mammalian species for zero-shot cell-type annotation and batch integration.
Single-cellSpatial omics22OpennessDeepSpot2Cell
142—Predicts virtual single-cell spatial transcriptomics from H&E histology using frozen pathology foundation models and spot-level supervision.
PathologySpatial omics58OpennessHistology vision transformer with 80M parameters that predicts spatial gene expression from H&E tissue images and transfers to tumor detection.
PathologySpatial omics59OpennessKRONOS
202391564Spatial proteomics foundation model, marker-aware and panel-agnostic, pretrained on 47 million multiplexed tissue-imaging patches from 175 markers.
Spatial omicsPathology12OpennessTera-MIND
1——Patch-based 3D diffusion model that generates teravoxel-scale virtual mouse brain volumes conditioned on spatially resolved gene expression.
Spatial omicsImaging78OpennessSpatialEx
37——Jilin University +1 otherFebruary 23, 2025contrastive_learningfoundation_modelgene_expression_prediction+6Histology-anchored framework pairing an H&E foundation model with a cellular hypergraph to predict single-cell multi-omics from tissue images.
Spatial omicsPathology57OpennessDeepCell Types
910—Cell phenotyping model for spatial proteomics using a language-informed vision transformer to classify cell types zero-shot across marker panels.
ImagingSpatial omics33Openness