All Competitors

Every biological foundation model, evaluated and ranked by the bio.rodeo team

Showing 4972 of 125 filtered models

  • Pert2Mol

    Purdue UniversityFebruary 4, 2026de_novo_designgenerativemolecular_generation+5

    Multimodal model that designs small molecules from transcriptomic and cell-imaging perturbation phenotypes with a rectified flow transformer.

    Small moleculeSingle-cell
    22Openness
  • scDiVa

    1
    Renmin University of ChinaFebruary 3, 2026batch_integrationcell_type_annotationdiffusion+6

    Single-cell foundation model built on masked discrete diffusion, jointly generating gene identities and expression values from 59 million cells.

    Single-cell
    6Openness
  • TwinCell

    2
    DeepLifeJanuary 29, 2026cancerfoundation_modelgene_regulation+4

    Large causal cell model trained on cancer perturbation data that generalizes zero-shot to patient-derived cells for therapeutic target prioritization.

    Single-cell
    19Openness
  • COSMIC

    EPFLJanuary 24, 2026autoencodercell_biologycell_type_annotation+7

    Bidirectional generative framework linking nuclear morphology and gene expression, built on a morphology model trained on 21 million segmented nuclei.

    ImagingSingle-cellSpatial omics
    4Openness
  • SAGE-FM

    Stanford UniversityJanuary 21, 2026cell_type_annotationfoundation_modelgene_expression+4

    Spatial transcriptomics foundation model built on a lightweight graph convolutional network and trained by masked central-spot prediction.

    Spatial omicsSingle-cell
    10Openness
  • Seoul National University HospitalJanuary 12, 2026cancercell_type_annotationdata_generation+6

    Single-cell RNA-seq language model that treats cells as gene-expression tokens, synthesizing whole transcriptomes from tissue and disease metadata.

    Single-cellSpatial omics
    2Openness
  • OKR-CELL

    BGI ResearchJanuary 9, 2026batch_effect_correctioncell_biologycell_clustering+7

    Cross-modal single-cell foundation model that aligns gene-expression profiles with LLM-enriched cell descriptions in a shared embedding space.

    Single-cellLanguage model
    23Openness
  • STACK

    14211
    Arc Institute +1 otherJanuary 9, 2026foundation_modelin_context_learningperturbation_prediction+4

    Single-cell foundation model using tabular attention over context cells to predict responses to arbitrary perturbations without fine-tuning.

    Single-cell
    33Openness
  • GEMGen

    2
    Westlake University +1 otherJanuary 3, 2026de_novo_designdrug_discoverygenerative+5

    Generative language model for phenotype-driven drug discovery, proposing small-molecule structures from up- and down-regulated gene signatures.

    Small moleculeSingle-cell
    9Openness
  • OmniCell

    1
    BGI ResearchDecember 29, 2025cell_type_annotationfoundation_modelgene_expression+6

    Transcriptomic foundation model pretrained on 67M single-cell and spatial profiles, modeling gene expression and inter-cellular dependencies.

    Single-cellSpatial omics
    9Openness
  • GenoME

    1
    Changping Laboratory +1 otherDecember 28, 2025chromatinepigenomicsfoundation_model+8

    Mixture-of-Experts generative model turning DNA sequence plus cell-type ATAC-seq into unified epigenomic, transcriptomic, and 3D chromatin profiles.

    DNA & GeneSingle-cell
    8Openness
  • FOCUS

    University of CambridgeDecember 23, 2025diffusionfoundation_modelgene_expression_imputation+8

    Generative foundation model that imputes genes and denoises spatial transcriptomics, conditioned on H&E histology, scRNA-seq, and spatial priors.

    Spatial omicsPathologySingle-cell
    4Openness
  • M-Optimus

    BioptimusDecember 17, 2025clinical_outcome_predictiondrug_target_identificationfoundation_model+8

    Multimodal foundation model that embeds histology, transcriptomics, and clinical records in one space for patient stratification and target discovery.

    PathologySpatial omicsSingle-cell
    3Openness
  • cfRNA-ICL

    Eigen BioDecember 13, 2025cancer_classificationcell_free_rnaearly_cancer_detection+7

    In-context learning model for cell-free RNA, meta-trained on synthetic tasks from a cfRNA structural causal model for few-shot cancer classification.

    Single-cellRNA
    8Openness
  • PanFoMa

    2
    Shanghai Jiao Tong University +4 othersDecember 2, 2025batch_correctioncancercell_type_annotation+7

    Pan-cancer single-cell foundation model with a hybrid Transformer-Mamba architecture, released with the PanFoMaBench cancer evaluation benchmark.

    Single-cell
    13Openness
  • ISTS

    New York UniversityDecember 2, 2025autoencoderbertcancer_classification+9

    Pan-cancer multi-omic foundation model encoding CpG-island DNA methylation and RNA-seq for zero-shot cancer classification and mutation prediction.

    Single-cellDNA & Gene
    20Openness
  • scMOBA

    Chinese Academy of Sciences +1 otherDecember 2, 2025cell_biologycell_type_annotationdata_integration+5

    Conversational single-cell and spatial multi-omics brain foundation model, with zero-shot cell annotation and disease prediction across species.

    Single-cellLanguage model
    5Openness
  • Tongji University +1 otherNovember 28, 2025cell_type_annotationfoundation_modelgene_expression+6

    Single-cell foundation model adapting LLaMA-3.1-8B with LoRA, recasting transcriptomes and protein interaction networks as natural-language Q&A pairs.

    Single-cellRNA
    55Openness
  • Carnegie Mellon UniversityNovember 27, 2025gene_expressiongenerativelanguage_model+4

    Spatial transcriptomics language model that reads tissue as spatial sentences to simulate cell profiles and run in silico perturbations.

    Spatial omicsSingle-cell
    53Openness
  • PULSAR

    364166
    Stanford UniversityNovember 26, 2025biomarker_predictiondisease_classificationfoundation_model+6

    Hierarchical single-cell foundation model that turns scRNA-seq profiles into zero-shot donor-level embeddings for disease and biomarker prediction.

    Single-cellProtein
    58Openness
  • MIMYR

    2
    Carnegie Mellon UniversityNovember 24, 2025cell_biologycell_type_annotationdata_imputation+6

    Generative framework that reconstructs missing spatial transcriptomics regions by jointly predicting cell locations, cell types, and gene expression.

    Spatial omicsSingle-cell
    16Openness
  • University of VirginiaNovember 4, 2025batch_correctioncell_type_annotationchromatin+7

    Transformer foundation model for single-cell ATAC-seq that embeds both cells and cis-regulatory elements for annotation and batch correction.

    Single-cellDNA & Gene
    32Openness
  • scLDM

    587
    Chan Zuckerberg InitiativeNovember 4, 2025autoencodercell_biologydata_augmentation+8

    Latent diffusion model for generating single-cell gene expression profiles, pairing a permutation-invariant autoencoder with a diffusion transformer.

    Single-cell
    75Openness
  • scLDM.CD4

    9198
    Chan Zuckerberg InitiativeNovember 4, 2025autoencodercell_biologydiffusion+7

    Single-cell latent diffusion model fine-tuned on 14.5 million CD4+ T cells to simulate transcriptomic effects of single-gene perturbations.

    Single-cell
    75Openness