All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 73–96 of 142 filtered models
- University of Maryland, College ParkNovember 24, 2025codon_optimizationde_novo_designfoundation_model+6
Conditional codon language model with 150M parameters that generates species-optimized coding sequences from a protein and its taxonomic lineage.
DNA & GeneRNA90Openness Melody
———Deep learning framework that predicts DNA methylation from genomic sequence across 39 human tissues, with an scRNA-seq variant for unseen cell types.
DNA & Gene8OpennessPuget
———Gene expression prediction model combining DNA sequence with Hi-C contact maps to capture 3D chromatin looping behind cell-type-specific expression.
DNA & Gene8OpennessMethylAI
7——Cross-species-pretrained CNN that predicts single-CpG DNA methylation from genomic sequence and interprets the cis-regulatory motifs that govern it.
DNA & Gene64OpennessEvo2HiC
102—University of WashingtonNovember 19, 2025chromatinchromatin_contact_predictionepigenomic_profiling+9Multimodal foundation model that distills Evo 2 into a compact encoder guided by Hi-C data, predicting cell-type-specific 3D genome architecture.
DNA & GeneSpatial omics57OpennessMergeDNA
—5—Hierarchical DNA foundation model that co-trains a dynamic token-merging tokenizer with latent Transformers to match genomic information density.
DNA & Gene5OpennessAtacformer
28297Transformer foundation model for single-cell ATAC-seq that embeds both cells and cis-regulatory elements for annotation and batch correction.
Single-cellDNA & Gene32OpennessVariantFormer
322—Hierarchical transformer with 1.2 billion parameters that predicts personalized gene expression from diploid genomes for variant effect prediction.
DNA & Gene68Openness- Verily Life SciencesOctober 24, 2025cross_attentiondisease_risk_predictionelectronic_health_records+7
Multimodal EHR foundation model that fuses polygenic risk scores into a GPT-2-style backbone by cross-attention for zero-shot disease risk prediction.
Language modelDNA & Gene8Openness NyxBind
1—2Hong Kong University of Science and TechnologyOctober 21, 2025bertbinding_site_predictioncontrastive_learning+5Transcription factor binding site prediction model that refines a DNABERT-2 backbone with contrastive learning across diverse TFBS types.
DNA & Gene40Openness- Weizmann Institute of Science +1 otherOctober 19, 2025gut_microbiomemasked_autoencodermetagenomics+2
Self-supervised models that embed gut metagenomic abundance profiles for robust phenotype prediction in data-limited, cross-cohort settings.
DNA & Gene23Openness FlashRNA
182—Efficient sequence-to-function transformer for regulatory genomics, matching Borzoi-class models while training in about a day on a single GPU.
DNA & GeneRNA59OpennessTabPFN-Wide
—7—Tabular foundation model adapted for extreme feature counts, enabling in-context prediction on wide omics tables with tens of thousands of features.
DNA & GeneSingle-cell32OpennessSciReasoner
90—44Multimodal scientific foundation model unifying protein, DNA/RNA, and small-molecule structure in one token vocabulary for cross-domain reasoning.
ProteinDNA & GeneSmall molecule66OpennessChromnitron
261—Multimodal foundation model predicting genome-wide binding of chromatin-associated proteins from protein sequence, DNA sequence, and chromatin state.
DNA & GeneProtein25OpennessAlphaGenome
2K154—DNA foundation model that predicts thousands of functional genomic tracks, from expression and splicing to chromatin, at single base-pair resolution.
DNA & Gene49Openness- University of Oregon +1 otherJune 24, 2025ancestral_recombination_graph_inferencecoalescence_time_estimationgenomics+4
Decoder-only transformer that recasts ancestral recombination graph inference as next-token prediction, estimating coalescence times from variation.
DNA & Gene83Openness LucaVirus
745155Multimodal viral foundation model over nucleotide and protein sequence, built for virus discovery, function annotation, and antibody design.
DNA & GeneProtein88OpennessBioMed Multi-Omic
62—23Open-source framework for building RNA and DNA foundation models, featuring WCED pretraining for transcriptomics and SNP-aware encoding for genomics.
DNA & Gene84OpennessseqLens
7——Genomic language models with disentangled attention, pretrained on prokaryotic and eukaryotic genomes for sequence classification and variant effects.
DNA & Gene18OpennessscDNAm-GPT
202—Guangzhou Medical University +1 otherFebruary 23, 2025cell_type_annotationcross_attentiondna_methylation+5Single-cell DNA methylation foundation model capturing genome-wide CpG dependencies in whole-genome bisulfite sequencing across tissues and species.
Single-cellDNA & Gene78Openness