All Competitors

Every biological foundation model, evaluated and ranked by the bio.rodeo team

Showing 124 of 31 filtered models

  • RepGene

    BGI ResearchJune 15, 2026autoencodergenomicsmultimodal+5

    Gene representation framework fusing DNA, transcript, protein, text, and single-cell embeddings into one latent space that survives missing views.

    DNA & GeneProteinSingle-cell
    22Openness
  • TxFM

    2
    Recursion PharmaceuticalsMay 31, 2026autoencoderfoundation_modelgene_expression+4

    Transcriptomics foundation model from Recursion that masks and reconstructs RNA-seq gene expression counts to learn reusable sample embeddings.

    Single-cell
    12Openness
  • FlowTransOP

    MIT +2 othersMay 27, 2026autoencodercross_domain_translationcross_species+7

    Flow-matching framework that translates omics signatures across biological domains, such as mouse to human transcriptomics, without paired samples.

    Single-cell
    87Openness
  • ETH ZurichMay 18, 2026autoencoderfold_classificationfoundation_model+5

    SE(3)-invariant masked autoencoder that learns protein fold representations from AlphaFold-DB structures, supporting zero-shot fold classification.

    Protein
    78Openness
  • PLM-SAE

    Shanghai Smart Logic Technology Co., Ltd.May 15, 2026autoencoderproteomicsrepresentation_learning+3

    Sparse autoencoders trained on protein language model embeddings to expose interpretable features and drive zero-shot variant effect prediction.

    Protein
    22Openness
  • NeuroVLM

    8
    University of California, San DiegoFebruary 9, 2026autoencoderbrain_decodingcontrastive_learning+2

    Vision-language foundation model linking human brain activation maps and neuroscience text for text-to-brain and brain-to-text generation.

    ImagingLanguage model
    74Openness
  • CaltechFebruary 6, 2026autoencoderprotein_designprotein_structure+4

    Protein structure tokenizer that encodes a whole structure globally, with each successive token adding detail for adaptive-length representations.

    Protein
    6Openness
  • CHASE

    ETH Zurich +1 otherFebruary 2, 2026autoencoderdirected_evolutionfitness_optimization+4

    Latent flow-matching method that repurposes protein language model embeddings to generate high-fitness protein variants without predictor guidance.

    Protein
    11Openness
  • COSMIC

    EPFLJanuary 24, 2026autoencodercell_biologycell_type_annotation+7

    Bidirectional generative framework linking nuclear morphology and gene expression, built on a morphology model trained on 21 million segmented nuclei.

    ImagingSingle-cellSpatial omics
    4Openness
  • ISTS

    New York UniversityDecember 2, 2025autoencoderbertcancer_classification+9

    Pan-cancer multi-omic foundation model encoding CpG-island DNA methylation and RNA-seq for zero-shot cancer classification and mutation prediction.

    Single-cellDNA & Gene
    20Openness
  • EvoSynth

    8
    University of Alabama at BirminghamNovember 4, 2025autoencoderde_novo_designdiffusion+6

    Multi-target drug discovery framework pairing a diffusion-transformer generator with evolutionary latent-space search and synthesis-aware scoring.

    Small molecule
    51Openness
  • scLDM

    587
    Chan Zuckerberg InitiativeNovember 4, 2025autoencodercell_biologydata_augmentation+8

    Latent diffusion model for generating single-cell gene expression profiles, pairing a permutation-invariant autoencoder with a diffusion transformer.

    Single-cell
    75Openness
  • scLDM.CD4

    9198
    Chan Zuckerberg InitiativeNovember 4, 2025autoencodercell_biologydiffusion+7

    Single-cell latent diffusion model fine-tuned on 14.5 million CD4+ T cells to simulate transcriptomic effects of single-gene perturbations.

    Single-cell
    75Openness
  • CellTok

    Tsinghua UniversityOctober 22, 2025autoencodercell_cell_communicationcell_type_annotation+7

    Multimodal LLM that tokenizes single cells into discrete VQ-VAE codebook tokens, letting one model reason jointly over transcriptomes and text.

    Single-cellLanguage model
    20Openness
  • ProteinAE

    212
    Chinese University of Hong Kong +2 othersOctober 12, 2025autoencoderde_novo_designdiffusion+5

    Protein structure autoencoder compressing backbone coordinates into a latent space, paired with a latent diffusion model for generative design.

    Protein
    74Openness
  • MagicDock

    Beijing Institute of TechnologyOctober 10, 2025autoencoderde_novo_designdrug_discovery+5

    De novo ligand design framework that generates protein binders and small molecules by inverting gradients through a differentiable docking model.

    ProteinSmall molecule
    33Openness
  • SLAE

    Stanford UniversityOctober 6, 2025all_atomautoencoderrepresentation_learning+2

    All-atom protein representation model that learns from each residue's strictly local atomic neighborhood, capturing side-chain geometry and chemistry.

    Protein
    20Openness
  • Kanzi

    384
    CaltechOctober 3, 2025autoencoderflow_matchinggenerative+4

    Flow-based protein structure tokenizer, a diffusion autoencoder replacing SE(3)-invariant components with global coordinates and standard attention.

    Protein
    63Openness
  • Tahoe-100M-SCVI

    1.7K123
    Tahoe TherapeuticsFebruary 20, 2025autoencodercancerembeddings+6

    scVI variational autoencoder trained on the Tahoe-100M drug-perturbation atlas, giving a 10-dimensional embedding of treated cancer cell states.

    Single-cell
    93Openness
  • SCimilarity

    258125
    GenentechNovember 20, 2024autoencodercell_type_annotationcontrastive_learning+3

    Single-cell foundation model trained by metric learning to embed scRNA-seq profiles for cell type annotation and similarity search in cell atlases.

    Single-cell
    78Openness
  • D-BETA

    3613120
    Singapore Management University +1 otherOctober 3, 2024autoencodercontrastive_learningecg_classification+6

    ECG foundation model pretrained on 12-lead waveforms paired with clinical reports, enabling label-efficient and zero-shot cardiac diagnosis.

    BiosignalsLanguage model
    27Openness
  • Chan Zuckerberg InitiativeJuly 1, 2024autoencodercell_type_annotationde_novo_design+6

    Variational autoencoder pretrained on 74 million human single-cell transcriptomes from the CELLxGENE Census for batch correction and cell typing.

    Single-cell
    96Openness
  • BrainMAE

    10
    Pennsylvania State UniversityJune 24, 2024age_predictionautoencoderbehavior_prediction+7

    Self-supervised masked autoencoder for functional MRI that learns representations from BOLD time-series with per-ROI embeddings and graph attention.

    Biosignals
    17Openness
  • OPERA

    8346
    University of CambridgeJune 23, 2024autoencodercontrastive_learningcough+7

    Respiratory acoustic foundation models pretrained on roughly 136K cough and breathing recordings for disease detection and lung function estimation.

    Biosignals
    59Openness