All Competitors

Every biological foundation model, evaluated and ranked by the bio.rodeo team

Showing 123 of 23 filtered models

  • miDGD

    Aarhus UniversityJune 2, 2026autoencoderdeep_generative_decodergene_expression+6

    A deep generative decoder that infers microRNA expression directly from bulk or single-cell mRNA gene expression via a shared mRNA/miRNA latent space.

    RNASingle-cell
    8Openness
  • TxFM

    2
    Recursion PharmaceuticalsMay 31, 2026autoencoderfoundation_modelgene_expression+4

    A self-supervised masked autoencoder for RNA-seq count data, pretrained on 1.4M public samples to learn transferable transcriptomic representations without per-dataset re-training.

    Single-cell
    12Openness
  • FlowTransOP

    MIT +2 othersMay 27, 2026autoencodercross_domain_translationcross_species+7

    A constrained deep flow-matching framework for distributional translation of omics signatures across biological domains, such as mouse-to-human transcriptomics, without paired samples.

    Single-cell
    87Openness
  • ETH ZurichMay 18, 2026autoencoderfold_classificationfoundation_model+5

    SE(3)-invariant masked autoencoder pretrained on ~370K AlphaFold-DB structures for protein fold representation learning, enabling frozen-feature and zero-shot fold classification.

    Protein
    78Openness
  • PLM-SAE

    Shanghai Smart Logic Technology Co., Ltd.May 15, 2026autoencoderproteomicsrepresentation_learning+3

    A mechanistic-interpretability framework that trains sparse autoencoders on protein language model embeddings to extract interpretable features for zero-shot variant effect prediction.

    Protein
    22Openness
  • CaltechFebruary 6, 2026autoencoderprotein_designprotein_structure+4

    A global protein structure tokenizer whose successive tokens add increasing detail, enabling adaptive-length representations, better generation, and zero-shot protein design.

    Protein
    6Openness
  • CHASE

    ETH Zurich +1 otherFebruary 2, 2026autoencoderdirected_evolutionfitness_optimization+4

    A latent flow-matching method that repurposes protein language model embeddings to generate high-fitness protein variants without predictor guidance during sampling.

    Protein
    11Openness
  • COSMIC

    EPFLJanuary 24, 2026autoencodercell_biologycell_type_annotation+7

    Bidirectional generative framework linking single-cell nuclear morphology and gene expression, built on a morphology foundation model trained on 21M+ segmented nuclei.

    ImagingSingle-cellSpatial omics
    4Openness
  • ISTS

    New York UniversityDecember 2, 2025autoencoderbertcancer_classification+9

    Pan-cancer multi-omic BERT-like foundation model that jointly encodes CpG-island DNA methylation and RNA-seq for zero-shot cancer classification and mutation prediction.

    Single-cellDNA & Gene
    20Openness
  • Chan Zuckerberg InitiativeNovember 4, 2025autoencodercell_biologydiffusion+8

    A fine-tuned scLDM variant trained on 14.5 million CD4+ T cells for counterfactual prediction of single-gene perturbation effects in immune cells.

    Single-cell
    75Openness
  • scLDM

    525
    Chan Zuckerberg InitiativeNovember 4, 2025autoencodercell_biologydata_augmentation+8

    A scalable latent diffusion model for generating realistic single-cell gene expression profiles, using a permutation-invariant VAE and flow-matching diffusion transformer.

    Single-cell
    75Openness
  • SCimilarity

    248112
    GenentechNovember 20, 2024autoencodercell_type_annotationcontrastive_learning+4

    Metric learning foundation model that embeds single-cell RNA-seq profiles into a unified space for scalable cell type annotation and cross-atlas similarity search across tens of millions of cells.

    Single-cell
    78Openness
  • D-BETA

    331323
    Singapore Management University +1 otherOctober 3, 2024autoencodercontrastive_learningecg_classification+6

    Contrastive masked ECG-text auto-encoder pretrained on paired electrocardiograms and clinical reports, enabling label-efficient and zero-shot cardiac diagnosis.

    BiosignalsLanguage model
    27Openness
  • Chan Zuckerberg InitiativeJuly 1, 2024autoencodercell_type_annotationde_novo_design+6

    A variational autoencoder pretrained on 74 million human single-cell transcriptomes from the CELLxGENE Census for scalable batch correction, cell typing, and data integration.

    Single-cell
    96Openness
  • BrainMAE

    10
    Pennsylvania State UniversityJune 24, 2024age_predictionautoencoderbehavior_prediction+7

    A region-aware masked-autoencoder framework that learns self-supervised representations directly from fMRI time-series via per-ROI embeddings and graph attention.

    Biosignals
    17Openness
  • OPERA

    8041
    University of CambridgeJune 23, 2024autoencodercontrastive_learningcough+7

    Open respiratory acoustic foundation models pretrained on ~136K curated cough and breathing recordings for health tasks such as disease detection and lung function estimation.

    Biosignals
    59Openness
  • LaMIM

    1919
    West China Hospital of Sichuan University +1 otherApril 17, 2024autoencoderbrain_mrifoundation_model+6

    Self-supervised vision transformer autoencoder pretrained on ~57,000 multi-contrast brain MRIs via masked image modeling for downstream brain tumor diagnosis.

    Imaging
    15Openness
  • IMPA

    2649
    Theis LabJanuary 8, 2024autoencodercell_biologydrug_discovery+5

    Generative image perturbation autoencoder that predicts cellular morphological responses to chemical and genetic perturbations using untreated cell images as input.

    Single-cell
    53Openness
  • mEthAE

    34
    Wageningen University & ResearchJuly 18, 2023autoencoderdna_methylationepigenomic_prediction+3

    Chromosome-wise explainable autoencoder for dimensionality reduction of DNA methylation data, achieving up to 400-fold compression while enabling interpretable CpG grouping analysis.

    DNA & Gene
    47Openness
  • XA4C

    3
    University of CalgaryJuly 17, 2023autoencodercell_type_annotationgene_expression+3

    Explainable autoencoder for transcriptome analysis that identifies critical genes using SHAP-based attribution of neural network latent representations.

    Single-cell
    58Openness
  • M3AE

    132183
    Shenzhen Research Institute of Big Data +2 othersSeptember 15, 2022autoencoderimage_text_retrievalmultimodal+5

    Self-supervised medical vision-and-language pretraining via multi-modal masked autoencoders that reconstruct masked image patches and text tokens.

    PathologyLanguage model
    29Openness
  • CPA

    146287
    Theis LabApril 15, 2021autoencoderdrug_response_modelinggenerative+5

    Compositional Perturbation Autoencoder that predicts single-cell transcriptional responses to unseen drug combinations and doses using disentangled latent representations.

    Single-cell
    78Openness
  • scVAE

    89
    Technical University of Denmark +1 otherAugust 15, 2020autoencodergene_expressionvariational_autoencoder

    Variational autoencoder for single-cell RNA-seq that models raw count distributions directly, producing latent cell representations without normalization preprocessing.

    Single-cell
    53Openness