Beijing Institute of Technology

Multi-label therapeutic peptide classifier over frozen ProtT5 embeddings, scoring 15 bioactivities from antimicrobial to quorum-sensing in one pass.

De novo ligand design framework that generates protein binders and small molecules by inverting gradients through a differentiable docking model.

Antibody and TCR CDR sequence design by structure retrieval, matching query loops against solved CDR structures rather than generating residues.

Transformer predicting microbial gene expression from an annotated genome alone, using protein language model embeddings of every coding sequence.

Prokaryotic promoter design and zero-shot promoter-strength ranking from a nucleotide language model pretrained on 17,806 microbial genomes.

Generative DNA language model for plasmid design and annotation, pretrained on 153,208 engineered plasmid sequences deposited in Addgene.

Mitochondrial ultrastructure segmentation in electron microscopy volumes, resolving membranes and cristae with cross-sample domain adaptation.

Universal brain lesion segmentation for multi-modal brain MRI, using a Mixture of Modality Experts to span diverse modalities and lesion types.

Nucleotide language model for prokaryotic promoter design, fine-tuned from one pretrained base into 27 species-specific generative checkpoints.