All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 73–96 of 203 filtered models
Protein structure tokenizer that encodes a whole structure globally, with each successive token adding detail for adaptive-length representations.
Protein6OpennessTM-Vec 2
—1—Protein structural homology search from sequence alone, embedding proteins so that structural similarity becomes a fast nearest-neighbor lookup.
Protein4OpennessFrustrAI-Seq
71—Helmholtz MunichFebruary 5, 2026frustration_predictionintrinsically_disordered_regionsprotein_function_annotation+4Protein language model that predicts per-residue local energetic frustration directly from sequence, covering whole proteomes and disordered regions.
Protein78OpennessevoRate
———Genome language model that adds evolutionary-rate prediction to pretraining, improving representations for variant effect and regulatory genomics.
DNA & Gene14OpennessCHASE
———Latent flow-matching method that repurposes protein language model embeddings to generate high-fitness protein variants without predictor guidance.
Protein11OpennessFoldVision
———Structure-based protein encoder that voxelizes every heavy atom into a 3D grid, learning orientation-robust representations for protein function.
Protein20OpennessSAGE-FM
———Spatial transcriptomics foundation model built on a lightweight graph convolutional network and trained by masked central-spot prediction.
Spatial omicsSingle-cell10OpennessPepEDiff
2——Zero-shot peptide binder designer that runs diffusion in a pretrained protein embedding space, proposing binders without structure prediction.
Protein62OpennessGluFormer
8719—Weizmann Institute of Science +2 othersJanuary 14, 2026continuous_glucose_monitoringfoundation_modelgenerative+6Generative transformer foundation model for continuous glucose monitoring, forecasting glycemia and stratifying health risk from raw glucose traces.
Biosignals60OpennessSequence-only latent diffusion model that designs target-specific peptide binders, cascaded with an affinity classifier through joint optimization.
ProteinSmall molecule4OpennessBiomeGPT
—1—Massachusetts General HospitalJanuary 5, 2026biomarker_discoverydisease_classificationfoundation_model+6Gut microbiome foundation model pretrained on human shotgun metagenomes, learning species-level taxonomic representations for disease prediction.
DNA & GeneLanguage model8OpennessMetagenBERT
———Annotation-free metagenome embedding pipeline that encodes raw DNA reads with genomic language models and pools them via FAISS k-means clustering.
DNA & Gene22OpennessMultimodal architecture coupling pretrained DNA, RNA, and protein language models with directional cross-attention into one Virtual Cell Embedding.
DNA & GeneRNAProtein22OpennessSpatialDINO
—1—Native 3D vision transformer self-supervised on unlabeled fluorescence microscopy volumes, segmenting subcellular structures without voxel labels.
Imaging8OpennessMicroGenomer
10——470M-parameter microbial genome foundation model trained on 234.5B base pairs for multi-scale genomic representation and trait prediction.
DNA & Gene44OpennessHELM-BERT
14—471Peptide language model trained on HELM notation, a DeBERTa encoder for property prediction on macrocyclic and non-canonical medium-sized peptides.
Small molecule80OpennessGlycanGT
3——Graph transformer foundation model for glycans, learning reusable embeddings of branched carbohydrate structures for glycomics prediction tasks.
Small molecule82OpennessISTS
———Pan-cancer multi-omic foundation model encoding CpG-island DNA methylation and RNA-seq for zero-shot cancer classification and mutation prediction.
Single-cellDNA & Gene20OpennessCLEF
554—Single-lead ECG foundation model pretrained on 12-lead recordings, weighting contrastive pairs by clinical risk for cardiovascular risk prediction.
Biosignals62OpennessTEA
2443.7KProtein sequence encoder that maps ESM2 embeddings to a learned 20-letter alphabet for structure-quality remote homology detection at MMseqs2 speed.
Protein86OpennessPULSAR
364166Hierarchical single-cell foundation model that turns scRNA-seq profiles into zero-shot donor-level embeddings for disease and biomarker prediction.
Single-cellProtein58OpennessFusionProt
183—Technion – Israel Institute of Technology +1 otherNovember 26, 2025function_predictiongraph_neural_networkmultimodal+4Multimodal protein representation model that iteratively fuses a sequence language model with a 3D structure encoder through a shared learnable token.
Protein68Openness