All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 73–96 of 106 filtered models
EvoSynth
8——Multi-target drug discovery framework pairing a diffusion-transformer generator with evolutionary latent-space search and synthesis-aware scoring.
Small molecule51OpennessscLDM
587—Latent diffusion model for generating single-cell gene expression profiles, pairing a permutation-invariant autoencoder with a diffusion transformer.
Single-cell75OpennessscLDM.CD4
9—198Single-cell latent diffusion model fine-tuned on 14.5 million CD4+ T cells to simulate transcriptomic effects of single-gene perturbations.
Single-cell75OpennessMolChord
—2—Structure-based drug design model that generates ligands for a protein pocket, pairing a diffusion structure encoder with preference optimization.
Small moleculeProtein23OpennessEnzyControl
103—Enzyme backbone design model that adds substrate and catalytic-site control to a pretrained SE(3) flow-matching generator via a lightweight adapter.
Protein86OpennessPearl
—6—Protein-ligand cofolding model that predicts 3D complex structures with SO(3)-equivariant diffusion, trained on physics-based synthetic data.
Protein18OpennessOpenFold3
7961—Open-source Apache-2.0 reproduction of AlphaFold3 that predicts all-atom structures of proteins, RNA, DNA, small molecules, and their complexes.
ProteinRNASmall molecule92OpennessPepTron
1311—Flow-matching model that predicts protein conformational ensembles across the order-disorder continuum, from folded domains to disordered chains.
Protein91OpennessRADiAnce
———Retrieval-augmented latent diffusion model for protein binder design, retrieving interfaces in a shared latent space across peptides and antibodies.
Protein26OpennessProteinAE
212—Protein structure autoencoder compressing backbone coordinates into a latent space, paired with a latent diffusion model for generative design.
Protein74OpennessFlexRibbon
—2—Protein foundation model with 3B parameters, pretrained jointly on sequence and 3D structure via masked language modeling and diffusion denoising.
Protein20OpennessDemoDiff
17623Graph diffusion transformer for in-context molecular design, adapting to new tasks from a few molecule-property demonstrations without fine-tuning.
Small molecule74OpennessSiD-Protein
11—Distilled few-step protein backbone generator that adapts Score Identity Distillation to Proteina for over 20x faster de novo structure sampling.
Protein76OpennessMorphGen
74—Institute of Science and Technology Austria +1 otherOctober 1, 2025cell_paintingdiffusiongenerative+4Diffusion model for multichannel fluorescent cell microscopy, generating morphologically plausible images aligned to OpenPhenom phenotypic embeddings.
ImagingSingle-cell22OpennessTDFold
———Single-sequence protein structure predictor that adapts image diffusion to generate 2D inter-residue templates, folding proteins without an MSA.
Protein10OpennessTera-MIND
12—Patch-based 3D diffusion model that generates teravoxel-scale virtual mouse brain volumes conditioned on spatially resolved gene expression.
Spatial omicsImaging78OpennessscDiffusion-X
404—Latent diffusion model for single-cell multi-omics generation and modality translation, with gradient-based inference of gene regulatory networks.
Single-cell85OpennessMINIM
158138—Text-to-image diffusion model that generates synthetic medical images across imaging modalities and organs to augment scarce clinical training data.
Imaging41OpennessProtenix
2K161—Open-source PyTorch reproduction of AlphaFold 3 under Apache 2.0, matching or exceeding AF3 on protein-ligand, protein-protein, and RNA benchmarks.
Protein76OpennessBrainfound
—4—Tsinghua University +2 othersJanuary 10, 2025contrastive_learningcross_modality_translationdiffusion+9Multimodal vision-text foundation model for brain CT and MRI, pretrained on roughly 10 million image-report pairs to act as a clinical copilot.
ImagingLanguage model7OpennessPLAID
12714—Latent diffusion model for controllable all-atom protein generation that co-designs sequence and structure while training on sequences alone.
Protein77Openness