All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 73–96 of 943 models
drug-SFM
—1—Specificity foundation model predicting small-molecule drug-target binding from sequence, scored as cross-modal retrieval without docking or assays.
Small molecule16OpennessChai-3
———Generative foundation model for antibody and multispecific design, doubling its predecessor's experimental success rate on therapeutic targets.
Protein4OpennessReCLIP
———University of Chicago +2 othersJune 4, 2026multi_taskprotein_protein_interaction_predictionproteomics+4Transformer that predicts protein-protein interactions at residue resolution, spanning mutations, PTMs, peptide-MHC binding, and disease variants.
Protein22OpennessDiffusion-based backbone generation and sequence design method for programmable asymmetric transmembrane beta-barrel nanopores.
Protein17OpennesscrisprSFM
—2—CRISPR off-target prediction model that scores gRNA-DNA specificity from sequence, framing guide-target recognition as cross-modal retrieval.
DNA & Gene19OpennessEmap2lig
2——Cryo-EM ligand modeling pipeline that detects bound ligand densities in a map, then reconstructs their atomic structures with a diffusion model.
ImagingSmall molecule25Opennessenzyme-SFM
—2—Enzyme-substrate specificity model that scores catalytic pairs from sequence with a physics-derived dual-encoder and a contrastive objective.
Protein23OpennessFlashABB
17——Oxford Protein Informatics Group (OPIG)June 4, 2026antibodydevelopability_predictionfoundation_model+4Pretrained antibody structure predictor that outputs full paired heavy/light 3D structures faster than protein language models generate embeddings.
Protein54OpennessmhcSFM
—2—Peptide-MHC binding specificity model that frames presentation as cross-modal retrieval, aligning peptide and MHC encoders by contrastive learning.
Protein23Opennessmir-SFM
—2—Foundation model that predicts microRNA-mRNA target specificity from sequence, using a dual-encoder trained with a symmetric contrastive objective.
RNA25OpennessLDARNet
4——Genomic foundation model with 120M parameters that learns adaptive DNA token boundaries by dynamic chunking, not fixed k-mer or byte-pair tokens.
DNA & Gene26OpennessSQUALL
—208—Multimodal foundation model pretrained on 1.76B histology and spatial transcriptomics spots, inferring molecular state from whole-slide images.
PathologySpatial omics6OpennessBrainGFM
173—Graph foundation model for fMRI brain networks, pretrained across 27 datasets with graph and language prompts for zero-shot disorder classification.
Biosignals16OpennessmiDGD
———Deep generative decoder that infers microRNA expression directly from bulk or single-cell mRNA expression via a shared mRNA/miRNA latent space.
RNASingle-cell8OpennessPepForge
41—Generative model for chemically modified and macrocyclic peptides that builds molecules in HELM notation, supporting de novo design and infilling.
ProteinSmall molecule94OpennessCryoProt
———Protein representation learning from cryo-EM density maps, transferring to flexibility, active-site, binding-affinity, and stability tasks.
ImagingProtein11OpennessTESSERA
561—Self-supervised foundation model that embeds cancer genomes from somatic SNVs and copy-number alterations across 33 tumor types for tumor subtyping.
DNA & Gene28OpennessVermeer
3228—Generative microscopy foundation model that synthesizes in-silico fluorescence images of protein subcellular localization from amino-acid sequence.
ImagingProtein17OpennessmRNAutilus
—1.2K—Masked discrete-diffusion model over millions of full-length mRNAs, steered by Monte Carlo tree search for joint codon optimization and UTR design.
RNA7OpennessTxFM
2——Transcriptomics foundation model from Recursion that masks and reconstructs RNA-seq gene expression counts to learn reusable sample embeddings.
Single-cell12OpennessAMix-2
———Protein-text foundation model placing amino acid sequences and natural language in one token space for protein understanding and de novo design.
ProteinLanguage model10OpennessSciCore-Omics
10154Tri-modal foundation model unifying histology images, spatial transcriptomics, and language for zero-shot pathology and spatial biology reasoning.
PathologySpatial omics65OpennessPIGMENT
———Physics-informed generative foundation model for quantitative diffusion MRI that maps brain microstructure and adapts zero-shot to each participant.
Imaging11Openness