All Competitors

Every biological foundation model, evaluated and ranked by the bio.rodeo team

Showing 7396 of 943 models

  • drug-SFM

    1
    ETH ZurichJune 4, 2026contrastive_learningcross_modal_retrievaldrug_repurposing+8

    Specificity foundation model predicting small-molecule drug-target binding from sequence, scored as cross-modal retrieval without docking or assays.

    Small molecule
    16Openness
  • Chai-3

    Chai DiscoveryJune 4, 2026antibodyantibody_designdrug_discovery+4

    Generative foundation model for antibody and multispecific design, doubling its predecessor's experimental success rate on therapeutic targets.

    Protein
    4Openness
  • ReCLIP

    University of Chicago +2 othersJune 4, 2026multi_taskprotein_protein_interaction_predictionproteomics+4

    Transformer that predicts protein-protein interactions at residue resolution, spanning mutations, PTMs, peptide-MHC binding, and disease variants.

    Protein
    22Openness
  • Institute for Protein Design +1 otherJune 4, 2026de_novo_designdiffusiongenerative+3

    Diffusion-based backbone generation and sequence design method for programmable asymmetric transmembrane beta-barrel nanopores.

    Protein
    17Openness
  • crisprSFM

    2
    ETH ZurichJune 4, 2026contrastive_learningcrisprcross_modal_retrieval+6

    CRISPR off-target prediction model that scores gRNA-DNA specificity from sequence, framing guide-target recognition as cross-modal retrieval.

    DNA & Gene
    19Openness
  • Emap2lig

    2
    Kihara Lab +1 otherJune 4, 2026atomic_modelingcryo_emdiffusion+6

    Cryo-EM ligand modeling pipeline that detects bound ligand densities in a map, then reconstructs their atomic structures with a diffusion model.

    ImagingSmall molecule
    25Openness
  • enzyme-SFM

    2
    ETH ZurichJune 4, 2026binding_predictioncontrastive_learningcross_modal_retrieval+6

    Enzyme-substrate specificity model that scores catalytic pairs from sequence with a physics-derived dual-encoder and a contrastive objective.

    Protein
    23Openness
  • FlashABB

    17
    Oxford Protein Informatics Group (OPIG)June 4, 2026antibodydevelopability_predictionfoundation_model+4

    Pretrained antibody structure predictor that outputs full paired heavy/light 3D structures faster than protein language models generate embeddings.

    Protein
    54Openness
  • mhcSFM

    2
    ETH ZurichJune 4, 2026binding_predictioncontrastive_learningcross_modal_retrieval+6

    Peptide-MHC binding specificity model that frames presentation as cross-modal retrieval, aligning peptide and MHC encoders by contrastive learning.

    Protein
    23Openness
  • mir-SFM

    2
    ETH ZurichJune 4, 2026contrastive_learningcross_modal_retrievaldual_encoder+6

    Foundation model that predicts microRNA-mRNA target specificity from sequence, using a dual-encoder trained with a symmetric contrastive objective.

    RNA
    25Openness
  • LDARNet

    4
    Independent ResearcherJune 3, 2026dnafoundation_modelgene_expression+6

    Genomic foundation model with 120M parameters that learns adaptive DNA token boundaries by dynamic chunking, not fixed k-mer or byte-pair tokens.

    DNA & Gene
    26Openness
  • SQUALL

    208
    Peking UniversityJune 3, 2026biomarker_discoveryfoundation_modelgene_expression+6

    Multimodal foundation model pretrained on 1.76B histology and spatial transcriptomics spots, inferring molecular state from whole-slide images.

    PathologySpatial omics
    6Openness
  • BrainGFM

    173
    Lehigh University +1 otherJune 2, 2026brain_connectomedisorder_classificationfmri+7

    Graph foundation model for fMRI brain networks, pretrained across 27 datasets with graph and language prompts for zero-shot disorder classification.

    Biosignals
    16Openness
  • miDGD

    Aarhus UniversityJune 2, 2026autoencoderdeep_generative_decodergene_expression+6

    Deep generative decoder that infers microRNA expression directly from bulk or single-cell mRNA expression via a shared mRNA/miRNA latent space.

    RNASingle-cell
    8Openness
  • Technical University of BerlinJune 2, 2026antimicrobial_peptidesbertde_novo_design+7

    Generative model for chemically modified and macrocyclic peptides that builds molecules in HELM notation, supporting de novo design and infilling.

    ProteinSmall molecule
    94Openness
  • TARIO-2

    NoetikJune 1, 2026foundation_modelgene_expressionhistology+4

    Tumor foundation model that infers whole-transcriptome and microenvironment signal from H&E slides, pretrained on paired spatial transcriptomics.

    PathologySpatial omics
    6Openness
  • CryoProt

    Hunan University +1 otherJune 1, 2026active_site_identificationbinding_affinitycryo_em+7

    Protein representation learning from cryo-EM density maps, transferring to flexibility, active-site, binding-affinity, and stability tasks.

    ImagingProtein
    11Openness
  • TESSERA

    561
    Weill Cornell MedicineJune 1, 2026cancer_genomicscell_type_annotationcontrastive_learning+5

    Self-supervised foundation model that embeds cancer genomes from somatic SNVs and copy-number alterations across 33 tumor types for tumor subtyping.

    DNA & Gene
    28Openness
  • Vermeer

    3228
    Microsoft Research +2 othersJune 1, 2026autoregressivecell_biologyfluorescence_microscopy+7

    Generative microscopy foundation model that synthesizes in-silico fluorescence images of protein subcellular localization from amino-acid sequence.

    ImagingProtein
    17Openness
  • mRNAutilus

    1.2K
    Atom Bioworks +3 othersMay 31, 2026de_novo_designdiffusionfoundation_model+5

    Masked discrete-diffusion model over millions of full-length mRNAs, steered by Monte Carlo tree search for joint codon optimization and UTR design.

    RNA
    7Openness
  • TxFM

    2
    Recursion PharmaceuticalsMay 31, 2026autoencoderfoundation_modelgene_expression+4

    Transcriptomics foundation model from Recursion that masks and reconstructs RNA-seq gene expression counts to learn reusable sample embeddings.

    Single-cell
    12Openness
  • AMix-2

    Shanghai AI Laboratory +4 othersMay 30, 2026diffusionfold_classificationfoundation_model+6

    Protein-text foundation model placing amino acid sequences and natural language in one token space for protein understanding and de novo design.

    ProteinLanguage model
    10Openness
  • Nanjing University +2 othersMay 30, 2026foundation_modelgene_expression_predictionhistology+5

    Tri-modal foundation model unifying histology images, spatial transcriptomics, and language for zero-shot pathology and spatial biology reasoning.

    PathologySpatial omics
    65Openness
  • PIGMENT

    Tsinghua UniversityMay 29, 2026diffusion_mrifoundation_modelgenerative+6

    Physics-informed generative foundation model for quantitative diffusion MRI that maps brain microstructure and adapts zero-shot to each participant.

    Imaging
    11Openness