All Competitors

Every biological foundation model, evaluated and ranked by the bio.rodeo team

Showing 4972 of 209 filtered models

  • MultiPUFFIN

    NTNU +2 othersMarch 1, 2026drug_discoveryfoundation_modelgraph_neural_network+6

    Multimodal foundation model pretrained on ~500K unlabeled PubChem molecules that jointly predicts nine thermophysical properties of small molecules.

    Small molecule
    10Openness
  • CellPace

    McGill UniversityFebruary 26, 2026cell_biologydiffusiongene_expression+5

    Temporal diffusion framework for single-cell developmental dynamics, interpolating and forecasting cell states from irregularly sampled time series.

    Single-cell
    9Openness
  • ChIANet

    Central South UniversityFebruary 25, 20263d_genomechromatinchromatin_contact_prediction+4

    Multimodal deep learning model that predicts protein-mediated chromatin contact maps and loops de novo from protein-binding profiles and sequence.

    DNA & Gene
    10Openness
  • MAP

    Shanghai Jiao Tong UniversityFebruary 25, 2026contrastive_learningdrug_response_predictiongraph_neural_network+6

    Knowledge-graph-grounded model that predicts single-cell transcriptomic responses to small molecules, with zero-shot prediction for unprofiled drugs.

    Single-cellSmall molecule
    12Openness
  • CLM-X

    Hangzhou Institute of Medicine, CASFebruary 18, 2026batch_correctioncell_biologycell_type_annotation+6

    Multimodal single-cell foundation model whose multiway Transformer jointly models scRNA-seq and scATAC-seq from RNA-only, ATAC-only, or paired inputs.

    Single-cell
    4Openness
  • SEAL

    484
    Mahmood Lab +2 othersFebruary 15, 2026cancer_subtypingfoundation_modelgene_expression_prediction+5

    Vision-omics finetuning that aligns pathology foundation models with spatial transcriptomics so morphology features predict local gene expression.

    PathologySpatial omics
    32Openness
  • DERIVE

    Guangzhou National LaboratoryFebruary 12, 2026flow_matchingfoundation_modelgenerative+5

    Multimodal generative model predicting viral antigenic change zero-shot from disentangled evolutionary, physicochemical, and structural signals.

    Protein
    16Openness
  • TerraBind

    Terray TherapeuticsFebruary 12, 2026binding_affinitydrug_discoveryfoundation_model+3

    Protein-ligand foundation model that maps coarse-grained structural representations directly to binding affinity, running ~26x faster than Boltz-2.

    ProteinSmall molecule
    24Openness
  • BioCLIP 2.5

    77435.3K
    Imageomics InstituteFebruary 10, 2026biodiversitycontrastive_learningfoundation_model+6

    Vision foundation model for the tree of life, scaling BioCLIP 2 to a ViT-H/14 backbone and more organism images for zero-shot species classification.

    Imaging
    93Openness
  • EVA

    89
    Scienta LabFebruary 10, 2026embeddingsfoundation_modelgene_expression+9

    Cross-species multimodal foundation model of immunology and inflammation, harmonizing transcriptomics and histology into patient-level embeddings.

    Single-cellRNAPathology
    27Openness
  • BioLM-Score

    Shenzhen UniversityFebruary 9, 2026binding_affinity_predictiondrug_discoverymixture_density_network+4

    Protein-ligand scoring function that conditions probabilistic geometric potentials on language model priors to rank docked poses and binding affinity.

    ProteinSmall molecule
    11Openness
  • BioBridge

    2
    Tongji University +1 otherFebruary 4, 2026continual_learninglanguage_modelmultimodal+5

    Connects a frozen protein language model to a general LLM via a cross-modal projector, adding protein reasoning without catastrophic forgetting.

    Language modelProtein
    13Openness
  • Pert2Mol

    Purdue UniversityFebruary 4, 2026de_novo_designgenerativemolecular_generation+5

    Multimodal model that designs small molecules from transcriptomic and cell-imaging perturbation phenotypes with a rectified flow transformer.

    Small moleculeSingle-cell
    22Openness
  • OpticalDNA

    Hunan UniversityFebruary 2, 2026dnafoundation_modelgenomics+5

    Vision-language DNA model that renders genomic sequence as visual layouts, reading regions up to 450,000 bases with about 20x better token efficiency.

    DNA & Gene
    16Openness
  • TwinCell

    2
    DeepLifeJanuary 29, 2026cancerfoundation_modelgene_regulation+4

    Large causal cell model trained on cancer perturbation data that generalizes zero-shot to patient-derived cells for therapeutic target prioritization.

    Single-cell
    19Openness
  • EnzyPGM

    2
    University of Science and Technology of China +1 otherJanuary 27, 2026de_novo_designenzyme_designgenerative+5

    Enzyme design model that jointly generates enzyme sequences and substrate-binding pockets, conditioned on functional priors and substrate structure.

    ProteinSmall molecule
    23Openness
  • COSMIC

    EPFLJanuary 24, 2026autoencodercell_biologycell_type_annotation+7

    Bidirectional generative framework linking nuclear morphology and gene expression, built on a morphology model trained on 21 million segmented nuclei.

    ImagingSingle-cellSpatial omics
    4Openness
  • OKR-CELL

    BGI ResearchJanuary 9, 2026batch_effect_correctioncell_biologycell_clustering+7

    Cross-modal single-cell foundation model that aligns gene-expression profiles with LLM-enriched cell descriptions in a shared embedding space.

    Single-cellLanguage model
    23Openness
  • SurfFlow

    6
    Stanford UniversityJanuary 8, 2026de_novo_designflow_matchinggenerative+5

    Flow-matching model for therapeutic peptide design that co-designs sequence, structure, and molecular surface to disrupt protein-protein interactions.

    ProteinSmall molecule
    18Openness
  • CMAP

    Amazon Web ServicesJanuary 7, 2026antibodyantibody_developabilityin_context_learning+4

    Antibody developability predictor pairing text and protein language models, using in-context learning to fit new assays without retraining.

    ProteinLanguage model
    4Openness
  • Nobuyuki OtaJanuary 3, 2026cell_biologygene_expressiongenomics+4

    Multimodal architecture coupling pretrained DNA, RNA, and protein language models with directional cross-attention into one Virtual Cell Embedding.

    DNA & GeneRNAProtein
    22Openness
  • Merlin

    4531366.9K
    Stanford UniversityJanuary 1, 2026cnncontrastive_learningct+8

    3D vision-language foundation model for abdominal CT, pretrained on scans, radiology reports, and EHR codes for zero-shot interpretation.

    ImagingLanguage model
    54Openness
  • GenoME

    1
    Changping Laboratory +1 otherDecember 28, 2025chromatinepigenomicsfoundation_model+8

    Mixture-of-Experts generative model turning DNA sequence plus cell-type ATAC-seq into unified epigenomic, transcriptomic, and 3D chromatin profiles.

    DNA & GeneSingle-cell
    8Openness
  • FOCUS

    University of CambridgeDecember 23, 2025diffusionfoundation_modelgene_expression_imputation+8

    Generative foundation model that imputes genes and denoises spatial transcriptomics, conditioned on H&E histology, scRNA-seq, and spatial priors.

    Spatial omicsPathologySingle-cell
    4Openness