All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 49–72 of 125 filtered models
Spatial transcriptomics language model that reads tissue as spatial sentences to simulate cell profiles and run in silico perturbations.
Spatial omicsSingle-cell53Openness- University of Maryland, College ParkNovember 24, 2025codon_optimizationde_novo_designfoundation_model+6
Conditional codon language model with 150M parameters that generates species-optimized coding sequences from a protein and its taxonomic lineage.
DNA & GeneRNA90Openness Pretrained language model for 3D molecule generation in protein pockets, unifying de novo and fragment-based drug design in one multi-task framework.
Small molecule8OpennessMultimodal conversational LLM for metabolite analysis, fusing a molecular-graph GNN and molecular-image CNN with a Vicuna-13B language backbone.
MetabolomicsSmall molecule48OpennessH3BERTa
1—201Antibody language model pretrained only on CDR-H3 loops, giving embeddings for immune repertoire analysis and antibody sequence classification.
ProteinLanguage model83OpennessPaired heavy/light antibody language model fine-tuning ESM-2 and ESM-C with CDR-preferential masking for zero-shot binding affinity embeddings.
Protein8OpennessCellTok
———Multimodal LLM that tokenizes single cells into discrete VQ-VAE codebook tokens, letting one model reason jointly over transcriptomes and text.
Single-cellLanguage model20OpennessKnowMol
95—Institute of Computing Technology, Chinese Academy of SciencesOctober 22, 2025cheminformaticsde_novo_designgraph_neural_network+6Multimodal molecular large language model grounding molecule understanding and generation in fine-grained, multi-level chemical knowledge.
Small moleculeLanguage model69Opennesspeleke-1
8—13Suite of large language models fine-tuned with LoRA to generate antigen-targeted antibody Fv sequences from an antigen and its epitope.
Protein74OpennessFcGPT
———Autoregressive protein language model for antibody Fc domains, reinforcement-tuned to design variants with programmable Fc-receptor binding profiles.
Protein20OpennessDynamicsPLM
11——Technion – Israel Institute of Technology +1 otherOctober 6, 2025conformational_dynamicsenzyme_function_predictionlanguage_model+4Protein language model conditioned on ensembles of computed conformations, giving state-aware embeddings for interaction, localization, and function.
Protein65OpennessEiRA
—2—Protein binder design model post-trained from a multimodal protein language model to bind proteins, peptides, small molecules, and nucleic acids.
Protein13OpennessstructRFM
36329RNA foundation model pretrained jointly on sequences and secondary structures for structure prediction, homology and splice site classification.
RNA92OpennessPoET-2
2710—Multimodal, retrieval-augmented protein foundation model that learns family-specific evolutionary constraints with optional structure conditioning.
Protein37OpennessDayhoff Atlas
9911—Protein language models trained on billions of natural and synthetic sequences for de novo design and zero-shot mutation-effect prediction.
Protein96Openness- University of Oregon +1 otherJune 24, 2025ancestral_recombination_graph_inferencecoalescence_time_estimationgenomics+4
Decoder-only transformer that recasts ancestral recombination graph inference as next-token prediction, estimating coalescence times from variation.
DNA & Gene83Openness Chiron-o1
601421Medical multimodal LLM (2B and 8B) trained for generalizable, step-by-step clinical reasoning via Mentor-Intern Collaborative Search.
PathologyImaging67OpennessmLLMCelltype
65310—Multi-LLM consensus framework for automated cell type annotation in scRNA-seq data, outperforming prior methods by ~15% in mean accuracy.
Single-cell37OpennessPinal
942914De novo protein design from natural language: a 16B-parameter framework turning text descriptions into sequences via structure-conditioned generation.
Protein42OpennessGMAI-VL-R1
1929—General medical vision-language model trained with reinforcement learning to reason step by step over medical images for diagnosis and visual QA.
ImagingLanguage model17OpennessseqLens
7——Genomic language models with disentangled attention, pretrained on prokaryotic and eukaryotic genomes for sequence classification and variant effects.
DNA & Gene18OpennessBrain2Qwerty
867——Brain-to-text decoder that reconstructs typed sentences from non-invasive MEG and EEG brain recordings using a CNN, transformer, and language model.
Biosignals11Openness