All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 1–6 of 6 filtered models
DISCO
196317Multimodal diffusion model that co-designs protein sequence and 3D structure around arbitrary biomolecules, demonstrated by designing novel heme enzymes catalyzing carbene-transfer reactions.
Protein70OpennessEnzyGen2
30——A 730M-parameter protein foundation model that co-designs enzyme sequence and 3D structure under small-molecule ligand guidance for de novo enzyme design.
ProteinSmall molecule89OpennessEnzyPGM
—1—University of Science and Technology of China +1 otherJanuary 27, 2026de_novo_designenzyme_designgenerative+5Pocket-conditioned generative model that jointly designs enzyme sequences and substrate-binding pockets conditioned on functional priors and substrate structure.
ProteinSmall molecule23OpennessRFdiffusion3
84844—All-atom diffusion model for de novo protein design conditioned on ligands, nucleic acids, and arbitrary non-protein atoms, enabling enzyme and DNA binder design.
Protein80OpennessRFdiffusion2
42788—Atom-level generative diffusion model for de novo enzyme design. Scaffolds arbitrary functional group geometries, solving all 41 benchmark active sites vs. 16/41 for prior methods.
Protein69OpennessLigandMPNN
584210—Protein sequence design method that explicitly models small molecules, nucleotides, and metals at atomic resolution, enabling ligand-aware design with 100+ validated designs.
Protein66Openness