All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 1–7 of 7 filtered models
DISCO
2103—Multimodal diffusion model that co-designs protein sequence and 3D structure around cofactors and small molecules for de novo heme enzyme design.
Protein70OpennessEnzyGen2
30——Protein foundation model for de novo enzyme design that co-designs sequence and 3D structure under small-molecule ligand guidance, at 730M parameters.
ProteinSmall molecule89OpennessEnzyPGM
—2—University of Science and Technology of China +1 otherJanuary 27, 2026de_novo_designenzyme_designgenerative+5Enzyme design model that jointly generates enzyme sequences and substrate-binding pockets, conditioned on functional priors and substrate structure.
ProteinSmall molecule23OpennessRFdiffusion3
90965—All-atom protein design diffusion model conditioned on ligands, nucleic acids, and other non-protein atoms, supporting enzyme and DNA binder design.
Protein80OpennessRFdiffusion2
439114—Atom-level diffusion model for de novo enzyme design that scaffolds arbitrary active-site geometries without specifying catalytic residue positions.
Protein69OpennessEnzyControl
103—Enzyme backbone design model that adds substrate and catalytic-site control to a pretrained SE(3) flow-matching generator via a lightweight adapter.
Protein86OpennessLigandMPNN
608233—Protein sequence design model that represents small molecules, nucleotides, and metals at atomic resolution, enabling ligand-aware enzyme design.
Protein66Openness