Institute for Protein Design
Part of University of Washington
Research institute for computational protein design
Models (5)
RFdiffusion3
Institute for Protein Design
All-atom diffusion model for de novo protein design conditioned on ligands, nucleic acids, and arbitrary non-protein atoms, enabling enzyme and DNA binder design.
RFdiffusion2
Institute for Protein Design
Atom-level generative diffusion model for de novo enzyme design. Scaffolds arbitrary functional group geometries, solving all 41 benchmark active sites vs. 16/41 for prior methods.
LigandMPNN
Institute for Protein Design
Protein sequence design method that explicitly models small molecules, nucleotides, and metals at atomic resolution, enabling ligand-aware design with 100+ validated designs.
RFdiffusion
Institute for Protein Design
Diffusion model for de novo protein design that generates novel backbone structures conditioned on binding targets, symmetry constraints, and functional motifs.
ProteinMPNN
Institute for Protein Design
Message passing neural network for fixed-backbone protein sequence design. Achieves 52.4% native sequence recovery, far surpassing Rosetta's 32.9%.