All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 25–48 of 518 filtered models
TCRDiff
7——Conditional denoising diffusion model that designs antigen-specific TCR CDR3β sequences conditioned on peptide-MHC targets and germline V-genes.
Protein75OpennessBetaInfer
———Technion – Israel Institute of Technology +2 othersJune 14, 2026generativegenomicsmolecular_evolution+4Generative transformer for phylogenetic inference that transduces sets of unaligned molecular sequences directly into Newick-format trees.
DNA & GeneProtein8OpennessMoE-Bind
2——Protein binder generator producing receptor-conditioned binders from sequence alone, using a sparse Mixture-of-Experts transformer with no 3D input.
Protein54OpennessRNARL
———Reinforcement-learning generative framework for multi-objective RNA codon optimization that generalizes across six species and five RNA types.
RNA4OpennessDNAGPT2
———Family of ten compact GPT-2 decoder-only DNA language models spanning BPE vocabularies from 16 to 8192 tokens, built for lossless genome compression.
DNA & Gene52OpennessGermRL
1—4Reinforcement learning framework that fine-tunes the ProGen2-OAS antibody language model with GRPO to cut germline bias in generated sequences.
Protein65OpennessHoloCell
———860M-parameter generative single-cell foundation model that jointly represents and generates epigenomic, transcriptomic, and proteomic modalities.
Single-cellDNA & Gene21OpennessTifBERT
2——Bulk RNA-seq foundation model learning normalization-robust transcriptome representations via TF-IDF gene ordering and masked gene modeling.
RNA17OpennessBacteReason
———University of TokyoJune 7, 2026antimicrobial_resistanceantimicrobial_resistance_predictionbacteria+5Reasoning LLM that predicts antimicrobial susceptibility of clinical bacterial isolates and supplies mechanistic explanations for each prediction.
DNA & GeneLanguage model20OpennessCREP
———Fine-tuned Enformer derivative that annotates cis-regulatory elements from DNA sequence, emitting enhancer, promoter, and insulator class labels.
DNA & Gene8OpennessMethylSeqNet
———University of California, Berkeley +1 otherJune 7, 2026chromatin_accessibility_predictiondna_methylationepigenetics+6Gene regulation model that conditions a pretrained DNA sequence embedding on CpG methylation to capture cell-type and allele-specific regulation.
DNA & Gene18OpennessSpineAgent
6——Multi-sequence spine MRI foundation model with DINOv3 encoders, supporting condition classification, pathology localization, and report generation.
Imaging55Opennesstf-SFM
—2—Transcription factor-DNA binding specificity prediction from sequence, with a physics-derived dual-encoder trained by symmetric contrastive learning.
DNA & Gene18Opennessdrug-SFM
—1—Specificity foundation model predicting small-molecule drug-target binding from sequence, scored as cross-modal retrieval without docking or assays.
Small molecule16OpennessReCLIP
———University of Chicago +2 othersJune 4, 2026multi_taskprotein_protein_interaction_predictionproteomics+4Transformer that predicts protein-protein interactions at residue resolution, spanning mutations, PTMs, peptide-MHC binding, and disease variants.
Protein22OpennesscrisprSFM
—2—CRISPR off-target prediction model that scores gRNA-DNA specificity from sequence, framing guide-target recognition as cross-modal retrieval.
DNA & Gene19OpennessEmap2lig
2——Cryo-EM ligand modeling pipeline that detects bound ligand densities in a map, then reconstructs their atomic structures with a diffusion model.
ImagingSmall molecule25Opennessenzyme-SFM
—2—Enzyme-substrate specificity model that scores catalytic pairs from sequence with a physics-derived dual-encoder and a contrastive objective.
Protein23OpennessFlashABB
19——Oxford Protein Informatics Group (OPIG)June 4, 2026antibodydevelopability_predictionfoundation_model+4Pretrained antibody structure predictor that outputs full paired heavy/light 3D structures faster than protein language models generate embeddings.
Protein54OpennessmhcSFM
—2—Peptide-MHC binding specificity model that frames presentation as cross-modal retrieval, aligning peptide and MHC encoders by contrastive learning.
Protein23Opennessmir-SFM
—2—Foundation model that predicts microRNA-mRNA target specificity from sequence, using a dual-encoder trained with a symmetric contrastive objective.
RNA25OpennessLDARNet
41—Genomic foundation model with 120M parameters that learns adaptive DNA token boundaries by dynamic chunking, not fixed k-mer or byte-pair tokens.
DNA & Gene26OpennessSQUALL
———Multimodal foundation model pretrained on 1.76B histology and spatial transcriptomics spots, inferring molecular state from whole-slide images.
PathologySpatial omics6Openness