All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 25–48 of 552 filtered models
RDiffusion
———Diffusion-based generative RNA model for de novo sequence design, conditioned on function, RNA family, structure, or binding proteins.
RNA5OpennessHoloCell
———860M-parameter generative single-cell foundation model that jointly represents and generates epigenomic, transcriptomic, and proteomic modalities.
Single-cellDNA & Gene21OpennessTifBERT
2——Bulk RNA-seq foundation model learning normalization-robust transcriptome representations via TF-IDF gene ordering and masked gene modeling.
RNA17OpennessMethylSeqNet
———University of California, Berkeley +1 otherJune 7, 2026chromatin_accessibility_predictiondna_methylationepigenetics+6Gene regulation model that conditions a pretrained DNA sequence embedding on CpG methylation to capture cell-type and allele-specific regulation.
DNA & Gene18OpennessSpineAgent
6——Multi-sequence spine MRI foundation model with DINOv3 encoders, supporting condition classification, pathology localization, and report generation.
Imaging55OpennessDaX
2——Pathology vision foundation model adapting DINOv3 self-supervised learning to whole-slide histopathology across many magnifications and scales.
Pathology11Opennesstf-SFM
—2—Transcription factor-DNA binding specificity prediction from sequence, with a physics-derived dual-encoder trained by symmetric contrastive learning.
DNA & Gene18Opennessdrug-SFM
—1—Specificity foundation model predicting small-molecule drug-target binding from sequence, scored as cross-modal retrieval without docking or assays.
Small molecule16OpennessChai-3
———Generative foundation model for antibody and multispecific design, doubling its predecessor's experimental success rate on therapeutic targets.
Protein4OpennesscrisprSFM
—2—CRISPR off-target prediction model that scores gRNA-DNA specificity from sequence, framing guide-target recognition as cross-modal retrieval.
DNA & Gene19Opennessenzyme-SFM
—2—Enzyme-substrate specificity model that scores catalytic pairs from sequence with a physics-derived dual-encoder and a contrastive objective.
Protein23OpennessFlashABB
19——Oxford Protein Informatics Group (OPIG)June 4, 2026antibodydevelopability_predictionfoundation_model+4Pretrained antibody structure predictor that outputs full paired heavy/light 3D structures faster than protein language models generate embeddings.
Protein54OpennessmhcSFM
—2—Peptide-MHC binding specificity model that frames presentation as cross-modal retrieval, aligning peptide and MHC encoders by contrastive learning.
Protein23Opennessmir-SFM
—2—Foundation model that predicts microRNA-mRNA target specificity from sequence, using a dual-encoder trained with a symmetric contrastive objective.
RNA25OpennessLDARNet
41—Genomic foundation model with 120M parameters that learns adaptive DNA token boundaries by dynamic chunking, not fixed k-mer or byte-pair tokens.
DNA & Gene26OpennessSQUALL
———Multimodal foundation model pretrained on 1.76B histology and spatial transcriptomics spots, inferring molecular state from whole-slide images.
PathologySpatial omics6OpennessBrainGFM
173—Graph foundation model for fMRI brain networks, pretrained across 27 datasets with graph and language prompts for zero-shot disorder classification.
Biosignals16OpennessCryoProt
———Protein representation learning from cryo-EM density maps, transferring to flexibility, active-site, binding-affinity, and stability tasks.
ImagingProtein11OpennessTESSERA
5——Self-supervised foundation model that embeds cancer genomes from somatic SNVs and copy-number alterations across 33 tumor types for tumor subtyping.
DNA & Gene28OpennessVermeer
3——Generative microscopy foundation model that synthesizes in-silico fluorescence images of protein subcellular localization from amino-acid sequence.
ImagingProtein17OpennessmRNAutilus
—1—Masked discrete-diffusion model over millions of full-length mRNAs, steered by Monte Carlo tree search for joint codon optimization and UTR design.
RNA7OpennessTxFM
2——Transcriptomics foundation model from Recursion that masks and reconstructs RNA-seq gene expression counts to learn reusable sample embeddings.
Single-cell12OpennessAMix-2
———Protein-text foundation model placing amino acid sequences and natural language in one token space for protein understanding and de novo design.
ProteinLanguage model10Openness