All Competitors

Every biological foundation model, evaluated and ranked by the bio.rodeo team

Showing 124 of 552 filtered models

  • Vilya-1

    VilyaJuly 10, 2026de_novo_designfoundation_modelmacrocyclic_peptides+1

    All-atom foundation model for macrocyclic peptide structure prediction, permeability estimation, and de novo design across non-canonical chemistries.

    ProteinSmall molecule
    5Openness
  • LEAF-1

    McGill University +1 otherJuly 10, 2026cancer_detectioncell_type_annotationcfdna+5

    Genomics foundation model that represents individual DNA fragments in a learned semantic space for cell-free DNA cancer detection and cell typing.

    DNA & GeneSingle-cell
    4Openness
  • IgGM2

    Tencent AI for Life Science Lab +3 othersJuly 9, 2026antibodydiffusionfoundation_model+4

    All-atom foundation model for immune-receptor design that predicts structures and co-designs CDR sequences for antibodies, nanobodies, and TCRs.

    Protein
    32Openness
  • HASSL

    2
    TUM.ai +3 othersJuly 5, 2026cell_biologycontrastive_learningfoundation_model+4

    Hierarchy-aware self-supervised model for single-cell microscopy that preserves morphological structure suppressed by imaging-modality confounders.

    ImagingSingle-cell
    37Openness
  • OpenDDE

    368
    AurekaJuly 4, 2026antibodyco_foldingdiffusion+2

    Open-source all-atom co-folding foundation model for protein-ligand, protein-protein, and antibody-antigen complex prediction in drug discovery.

    ProteinSmall molecule
    75Openness
  • StructureSAFE

    Purdue UniversityJuly 2, 2026foundation_modelgenerativelead_optimization+1

    Structure-based drug design language model fusing protein structural and evolutionary encoders with SAFE fragment tokens for hit-to-lead generation.

    Small moleculeProtein
    10Openness
  • WattmaMod

    Shandong University +3 othersJuly 2, 2026contrastive_learningepitranscriptomicsfoundation_model+4

    RNA modification profiling from nanopore direct RNA-seq signal; self-supervised pretraining resolves 11 modification types and extends to new ones.

    RNABiosignals
    21Openness
  • GAZE

    Leiden University Medical CenterJuly 2, 2026enzymesfoundation_modelgraph_neural_network+2

    Physics-informed graph neural network predicting metabolite concentrations from gene expression, generalizing zero-shot to unseen metabolites.

    MetabolomicsSmall moleculeDNA & Gene
    19Openness
  • University of California, San DiegoJuly 1, 2026brain_mridisease_classificationfoundation_model+1

    Brain MRI morphometry model that estimates cortical thickness, surface area, and volume in milliseconds instead of hours.

    Imaging
    47Openness
  • Canopy

    Twig BioJuly 1, 2026enzymesfoundation_modelheterogeneous_graph_transformer+5

    Heterograph foundation model for metabolic engineering, fusing protein, chemistry, and text embeddings over a 6.9M-node biological knowledge graph.

    ProteinSmall moleculeDNA & Gene
    21Openness
  • CryoACE

    ShanghaiTech UniversityJune 30, 2026cryo_emdiffusionfoundation_model+2

    Atomic protein model building from cryo-EM density maps, resolving conformational heterogeneity through atom-centric sampling and diffusion.

    ProteinImaging
    38Openness
  • ZAO

    SyntheticGestaltJune 25, 2026admet_predictionfoundation_modelrepresentation_learning+1

    Molecular foundation model that turns SMILES into 2048-dimensional embeddings from multiple 3D conformations for ADMET and virtual screening.

    Small molecule
    16Openness
  • PlantGeneAnn

    12126
    Huazhong Agricultural UniversityJune 25, 2026dnafoundation_modelgene_structure_annotation+7

    Plant genome foundation model for ab initio gene structure annotation, predicting genes, coding sequences, and exons at single-nucleotide resolution.

    DNA & Gene
    66Openness
  • Molexar

    717
    Peking UniversityJune 24, 2026de_novo_designdrug_designdrug_discovery+5

    Multimodal molecular generation model for drug design, conditioned on properties, pharmacophores, protein sequences, or protein binding pockets.

    Small moleculeProtein
    82Openness
  • CellOS

    Vitaura +2 othersJune 23, 2026batch_integrationcell_type_annotationfoundation_model+6

    Multi-view single-cell foundation model at 12B parameters, aligning expression and perception views with an LLM-JEPA joint-embedding objective.

    Single-cell
    8Openness
  • EventHorizon

    ARUP Laboratories +1 otherJune 22, 2026cell_type_annotationdiagnostic_classificationflow_cytometry+6

    Self-supervised foundation model for clinical flow cytometry, producing panel-agnostic specimen-level representations from multi-panel data.

    BiosignalsSingle-cell
    4Openness
  • BioMatrix

    41167
    Shanghai AI Laboratory +1 otherJune 20, 2026foundation_modellanguage_modelmolecule_generation+6

    Decoder-only foundation model that unifies sequences, 3D structures, and natural language for small molecules and proteins in one shared token space.

    ProteinSmall moleculeLanguage model
    67Openness
  • Hong Kong University of Science and Technology +4 othersJune 18, 2026foundation_modelself_supervisedtransfer_learning+1

    NMR foundation model trained on 158 million simulated 1H and 13C spectra, transferring simulation-learned representations to real experimental data.

    Small moleculeMetabolomics
    43Openness
  • BoltzMol-1

    4.1K
    BoltzJune 16, 2026diffusiondrug_discoveryfoundation_model+4

    Small-molecule hit-discovery pipeline using Boltz-2 co-folding and affinity prediction to rank in-stock compounds or make-on-demand chemical space.

    Small moleculeProtein
    7Openness
  • BoltzProt-1

    4.1K
    BoltzJune 16, 2026antibodybinder_designfoundation_model+5

    De novo protein binder and nanobody design pipeline that ranks candidates by a protein-protein interaction model rather than structural confidence.

    Protein
    11Openness
  • vBx-1.0

    Verge LabsJune 16, 2026contrastive_learningfoundation_modelgene_expression+5

    Multimodal foundation model for precision neurology that reconstructs a patient's molecular brain state from blood to predict disease progression.

    Single-cellDNA & Gene
    5Openness
  • Tox21mer

    National Institute of Environmental Health SciencesJune 15, 2026embeddingsfoundation_modelrepresentation_learning+2

    Toxicity screening foundation model that encodes Tox21 concentration-response curves and assay metadata into reusable 768-dimensional embeddings.

    Small moleculeBiosignals
    23Openness
  • Omnii

    Radical NumericsJune 15, 2026convolutionaldnafoundation_model+6

    Genomic language model from Radical Numerics with a 2 Mbp context window, built for zero-shot variant effect prediction and sequence design.

    DNA & Gene
    5Openness
  • TCRDiff

    7
    Monash UniversityJune 14, 2026antibodyde_novo_designdiffusion+5

    Conditional denoising diffusion model that designs antigen-specific TCR CDR3β sequences conditioned on peptide-MHC targets and germline V-genes.

    Protein
    75Openness