All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 25–48 of 55 filtered models
OpticalDNA
———Vision-language DNA model that renders genomic sequence as visual layouts, reading regions up to 450,000 bases with about 20x better token efficiency.
DNA & Gene16OpennessGENERator-v2
4601—Family of autoregressive genomic foundation models that reconcile k-mer tokenization with single-nucleotide resolution at contexts up to 98k bp.
DNA & Gene86OpennessGengram
51——Retrieval-augmented genomic foundation model that gives transformer backbones a hash-based k-mer motif memory for functional genomics tasks.
DNA & Gene83OpennessDNAChunker
—1—Masked DNA language model with a learnable, adaptive tokenizer that produces context-dependent, variable-length segments instead of fixed k-mers.
DNA & Gene23OpennessMetagenBERT
———Annotation-free metagenome embedding pipeline that encodes raw DNA reads with genomic language models and pools them via FAISS k-means clustering.
DNA & Gene22OpennessNucleotide Transformer v3 (NTv3)
901234.8KMulti-species genomics foundation model spanning representation learning, functional-track prediction, and sequence generation at 1 Mb context.
DNA & Gene25OpennessPlantBiMoE
8—6Plant genome foundation model pairing a bidirectional Mamba backbone with sparse Mixture-of-Experts, pretrained on 25.4B nucleotides from 42 species.
DNA & Gene53OpennesseccDNAMamba
5——Bidirectional state-space (Mamba-2) genomic model for ultra-long extrachromosomal circular DNA, scaling linearly with sequence length.
DNA & Gene54OpennessPuget
———Gene expression prediction model combining DNA sequence with Hi-C contact maps to capture 3D chromatin looping behind cell-type-specific expression.
DNA & Gene8OpennessMethylAI
7——Cross-species-pretrained CNN that predicts single-CpG DNA methylation from genomic sequence and interprets the cis-regulatory motifs that govern it.
DNA & Gene64OpennessVariantFormer
322—Hierarchical transformer with 1.2 billion parameters that predicts personalized gene expression from diploid genomes for variant effect prediction.
DNA & Gene68OpennessNyxBind
1—2Hong Kong University of Science and TechnologyOctober 21, 2025bertbinding_site_predictioncontrastive_learning+5Transcription factor binding site prediction model that refines a DNABERT-2 backbone with contrastive learning across diverse TFBS types.
DNA & Gene40OpennessEiRA
—2—Protein binder design model post-trained from a multimodal protein language model to bind proteins, peptides, small molecules, and nucleic acids.
Protein13OpennessEvo 2
4K28811.8KGenomic foundation model trained on 9.3 trillion DNA base pairs across all domains of life, with 40B parameters and a 1-million-token context.
DNA & Gene92OpennessEvo
1.5K2501.8KGenomic foundation model with 7B parameters that models prokaryotic DNA, RNA, and protein at single-nucleotide resolution over a 131k-token context.
DNA & Gene70OpennessOpenCRISPR-1
1.2K80—AI-designed CRISPR-Cas9 gene editor generated by protein language models trained on 1.2 million CRISPR operons and shown to edit the human genome.
Protein16OpennessDNABERT-S
1305324.1KDNA embedding model built on DNABERT-2, using contrastive learning to cluster sequences by species for metagenomic binning without labeled data.
DNA & Gene53OpennessCaLM
5445—Codon-level BERT model that captures genomic signals invisible to amino acid models, outperforming billion-parameter PLMs with just 86M parameters.
Protein66OpennessGPN-MSA
34990216DNA language model for variant effect prediction across coding and non-coding regions, using whole-genome alignments of 100 vertebrate species.
DNA & Gene87OpennessDNAGPT
46——GPT-style DNA foundation model trained on over 200 billion base pairs of mammalian genomes for sequence generation, classification, and regression.
DNA & Gene6OpennessDNABERT-2
507456170.4KMulti-species genomic foundation model swapping k-mer tokenization for byte pair encoding, matching Nucleotide Transformer with 21x fewer parameters.
DNA & Gene64Openness