XtalPi

miRNA-target interaction model fusing five gated evidence experts, whose frozen representation transfers to siRNA efficacy prediction.

De novo siRNA design conditioned on target mRNA context, generating 21-nt duplexes by masked discrete diffusion under efficacy guidance.

Protein-ligand affinity foundation model that embeds pockets and ligands in one space, unifying virtual screening with hit-to-lead optimization.

Single-cell foundation model built on MAMBA2 state-space blocks, reading all 60,530 genes of a transcriptome without variable-gene selection.

mRNA language model embedding the joint 5' UTR and coding sequence to predict translation efficiency, expression level, and transcript stability.

Antibody language model pretrained on 18M OAS Fv sequences with a 70% CDR-H3-targeted mask, giving embeddings for pairing and binding prediction.