An independent AI research institute in Toronto bridging machine learning discovery and real-world adoption in health, biosignals, and imaging.
Whole-transcriptome inference from label-free live-cell phase-contrast microscopy, predicting 18,085 genes without staining or lysing the cells.
Multimodal reasoning LLM for protein function prediction, fusing protein language model embeddings to emit interpretable GO-term reasoning traces.
University Health Network / University of Toronto / Vector Institute
Released September 1, 2025
Image-to-image translation from label-free phase-contrast microscopy to H&E-like images, so pretrained histopathology models run on live cells.
University of Toronto / The Hospital for Sick Children / University of Cambridge / ETH Zurich / Vector Institute / Mila / McGill University / Caltech
Released July 16, 2025
Synthesizable 3D molecule generation that jointly samples building blocks, reactions, and atomic coordinates, returning a synthesis route per design.
University of Toronto / Ontario Institute for Cancer Research / Vector Institute
Released July 5, 2025
Single-cell perturbation foundation model predicting transcriptomic responses to CRISPR and small-molecule interventions in cancer cells.
University of Waterloo / Vector Institute / National Research Council Canada
Released June 17, 2025
Text-guided protein editing framework with disentangled structure and function latents, edited by rewriting either description at inference time.
Bowang Lab / University of Toronto / Vector Institute / University Health Network / Arc Institute / UCSF
Released May 29, 2025
DNA-LLM reasoning model fusing genome foundation model embeddings with an LLM to produce step-by-step pathway and variant effect explanations.
Bowang Lab / University Health Network / Vector Institute / University of Toronto / Harvard Medical School
Released April 4, 2025
Promptable 3D medical image and video segmentation foundation model fine-tuned from SAM 2.1, cutting lesion annotation time by up to 92%.
Chest X-ray encoder that detects CT-level abnormalities by aligning radiographs with 3D CT volumes and radiology reports in a shared embedding space.
University of Waterloo / University of Guelph / Simon Fraser University / Vector Institute / Alberta Machine Intelligence Institute
Released February 25, 2025
DNA barcode foundation model whose masked-autoencoder pretraining keeps mask tokens out of the encoder, for arthropod taxonomic classification.
Bowang Lab / University Health Network / University of Toronto / Vector Institute / Arc Institute / UCSF
Released February 8, 2025
Spatial transcriptomics foundation model continually pretrained on 30 million profiles, with a protocol-aware mixture-of-experts decoder.
Microsoft Research / Imperial College London / Vector Institute / University Health Network
Released February 5, 2025
Autoregressive genomic foundation models from 20M to 1B parameters that solve ten DNA tasks at once and map sequences to text and images.
University of Toronto / Sunnybrook Research Institute / Vector Institute
Released January 20, 2025
3D medical imaging foundation model self-supervised on roughly 100,000 MRI, CT, and PET volumes spanning more than ten organs and three modalities.
University of Toronto / University Health Network / Vector Institute / Broad Institute / Structural Genomics Consortium
Released December 20, 2024
Latent diffusion model that paints high-resolution Cell Painting images of cells responding to a chemical compound or an over-expressed gene.
Princeton University / Ludwig Institute for Cancer Research / University of Alberta / Alberta Machine Intelligence Institute / University of Toronto / Vector Institute / University of British Columbia / Baylor College of Medicine / Fudan University / Provincial Health Services Authority / Norton Research Institute
Released November 15, 2024
Chemical language model of the human metabolome that generates and ranks candidate structures for unidentified mass spectrometry peaks.
Harvard Medical School / Brigham and Women's Hospital / Harvard University / MIT / University Health Network / University of Toronto / Vector Institute / University of Edinburgh
Released November 3, 2024
DNA methylation foundation model over 49,156 array CpG sites. Imputes missing values, embeds samples, and predicts epigenetic age and disease risk.
Open transformer foundation model for 12-lead electrocardiograms, pretrained on 1.5 million unlabeled ECGs with a wav2vec 2.0 self-supervised recipe.
Bowang Lab / University Health Network / University of Toronto / Vector Institute / Western University / New York University / Yale University
Released January 22, 2024
Promptable foundation model for universal medical image segmentation, fine-tuned from SAM on 1.57M image-mask pairs across 10 imaging modalities.
University of Toronto / Vector Institute / Li Ka Shing Knowledge Institute
Released January 28, 2021
EEG foundation model pretrained on clinical recordings with a wav2vec 2.0-style contrastive task, transferring to BCI decoding and sleep staging.
University of Waterloo / Huron Technologies / McMaster University / University of Toronto / University of Pittsburgh / Vector Institute
Released January 20, 2021
Histopathology patch encoder giving 1024-dimensional embeddings for slide search and cancer subtyping, trained on TCGA with weak slide labels.