Multimodal diffusion protein language model co-generating sequence and structure. Bit-level structure supervision cuts folding RMSD from 5.52 to 2.36.
University of North Carolina at Chapel Hill / Rutgers University / Barnard College / Lawrence Livermore National Laboratory
Released March 3, 2025
Structure-aware adapter that injects chromatin-derived gene regulatory networks into single-cell RNA foundation models like scGPT and scFoundation.
Pocket-conditioned 3D ligand generator built on rectified flow, reaching -8.50 average Vina Dock and 75.0% diversity on CrossDocked2020.