RIKEN Center for Advanced Intelligence Project

Reasoning-guided foundation model for de novo antibody CDR design, pairing a multimodal LLM understanding expert with a Boltz-1 diffusion expert.

Molecular scaffold optimization that grafts generated fragments onto a lead compound, guided by Bayesian search in a conditional VAE latent space.

Compound-protein interaction prediction coupling a chemical language model to a protein language model via a cross-attention block.