Lanzhou University

Preparation-free protein-ligand binding affinity prediction from a protein sequence and a ligand SMILES, using a cascaded mixture-of-experts fusion.

Peptide-protein interaction prediction that scores a pair and maps the interface residues on both the peptide and the protein from sequence alone.

DNA sequence embedding model that approximates edit distance via contrastive fine-tuning of DNABERT-2, improving similar-sequence search accuracy.

Phosphorylation site prediction from protein sequence. A LoRA-adapted ESM-2 encoder feeds a conformer, reaching 79.5% AUC at serine sites.

Conditional GAN that generates small molecules against a protein-protein interaction interface, encoding the complex with graph attention networks.