Karolinska Institutet

Designs macrocyclic peptide molecular glues bridging two target proteins from sequence alone, validated as VHL-recruiting degraders in cells.

Protein structure prediction and peptide binder design model covering the 20 canonical amino acids plus 29 noncanonical residues.

Protein language model that generates paired heavy and light chain human antibodies from an antigen prompt, with binders validated in vitro.

Spot detection and quantification in 5D fluorescence microscopy. Pretrained 2D and 3D U-Nets segment foci, then Gaussian fitting measures each one.